{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T20:23:26Z","timestamp":1787775806404,"version":"build-2784847793"},"reference-count":24,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","license":[{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction:<\/jats:title>\n                    <jats:p>We aimed to describe the clinical presentation and response to recombinant growth hormone (rGH) in Indian girls with Turner syndrome (TS).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>This retrospective study included 33 girls with TS attending a tertiary care hospital in Northern India between 2004 and 2023. Data on clinical presentation, cytogenetics and follow-up were retrieved from clinic records. In addition, auxological data was analysed for girls who received rGH therapy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      The mean age at presentation was 9.8 \u00b1 3.9 years (range 2\u201317.7 years). 57.6% had classical TS, whereas, 42.4% had variant TS karyotypes. The commonest presenting features were short stature (100%) and delayed puberty (27.3%). Autoimmune hypothyroidism and celiac disease were the commonest associated co-morbidities. Pubertal induction with estradiol was done in seven patients. Sixteen (48.5%) patients received rGH at a mean starting dose of 0.29 mg\/kg\/week. The mean age and bone age (BA) at rGH initiation were 10.0 \u00b1 3.3 years and 8.3 \u00b1 3.0 years, respectively. There were significant improvements in Turner\u2019s height standard deviation scores (SDS) (\u22120.7 to 0.19;\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.003), BA (8.3 \u00b1 3.0 to 10.2 \u00b1 2.9;\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.003) and predicted adult height (PAH) (142.2 cm to 147.4 cm;\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; 0.001) over a median duration of rGH therapy of 16 months (IQR 6\u201351 months). There was a strong positive correlation between height gain and duration of rGH therapy (\n                      <jats:italic toggle=\"yes\">r<\/jats:italic>\n                      = 0.967;\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; 0.001).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>North Indian girls with TS demonstrate a good response to rGH with improvements in height SDS, PAH, and skeletal growth. The duration of rGH significantly impacts height gain; early initiation is therefore crucial for attaining near-normal final height.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/ijem.ijem_348_24","type":"journal-article","created":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T15:01:12Z","timestamp":1772204472000},"page":"102-106","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":0,"title":["Clinical Profile and Response to Recombinant Growth Hormone in Girls with Turner Syndrome: Experience from a Tertiary Care Centre in North India"],"prefix":"10.4103","volume":"30","author":[{"given":"Pamali M.","family":"Nanda","sequence":"first","affiliation":[{"name":"Department of Pediatrics, Endocrinology and Diabetes Unit, Post Graduate Institute of Medical Education and Research, Chandigarh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arti","family":"Yadav","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Endocrinology and Diabetes Unit, Post Graduate Institute of Medical Education and Research, Chandigarh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arun","family":"George","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Endocrinology and Diabetes Unit, Post Graduate Institute of Medical Education and Research, Chandigarh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sayan","family":"Banerjee","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Endocrinology and Diabetes Unit, Post Graduate Institute of Medical Education and Research, Chandigarh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anju","family":"Bala","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Endocrinology and Diabetes Unit, Post Graduate Institute of Medical Education and Research, Chandigarh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jaivinder","family":"Yadav","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Endocrinology and Diabetes Unit, Post Graduate Institute of Medical Education and Research, Chandigarh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rakesh","family":"Kumar","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Endocrinology and Diabetes Unit, Post Graduate Institute of Medical Education and Research, Chandigarh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Inusha","family":"Panigrahi","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Genetic Metabolic Unit, Post Graduate Institute of Medical Education and Research, Chandigarh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Devi","family":"Dayal","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Endocrinology and Diabetes Unit, Post Graduate Institute of Medical Education and Research, Chandigarh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2026,2,27]]},"reference":[{"key":"R1-20260302","doi-asserted-by":"crossref","first-page":"566","DOI":"10.1210\/endo-23-5-566","article-title":"Classic pages in obstetrics and gynecology by Henry H. 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A syndrome of infantilism, congenital webbed neck, and cubitus valgus","volume":"23","year":"1938","journal-title":"Endocrinology"},{"key":"R2-20260302","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/j.yapd.2022.03.004","article-title":"Turner syndrome: An update","volume":"69","author":"Steiner","year":"2022","journal-title":"Adv Pediatr"},{"key":"R3-20260302","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1210\/jc.2006-1374","article-title":"Care of girls and women with Turner syndrome: A guideline of the turner syndrome study group","volume":"92","author":"Bondy","year":"2007","journal-title":"J Clin Endocrinol Metab"},{"key":"R4-20260302","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1016\/j.fertnstert.2012.08.021","article-title":"Genetic considerations in the patient with turner syndrome--45, X with or without mosaicism","volume":"98","author":"Zhong","year":"2012","journal-title":"Fertil Steril"},{"key":"R5-20260302","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1111\/j.1651-2227.1988.tb10796.x","article-title":"Spontaneous growth in turner's syndrome","volume":"343","author":"Ranke","year":"1988","journal-title":"Acta Paediatr Scand Suppl"},{"key":"R6-20260302","doi-asserted-by":"crossref","first-page":"G1","DOI":"10.1530\/EJE-17-0430","article-title":"Clinical practice guidelines for the care of girls and women with Turner syndrome: Proceedings from the 2016 cincinnati international turner syndrome meeting","volume":"177","author":"Gravholt","year":"2017","journal-title":"Eur J Endocrinol"},{"key":"R7-20260302","doi-asserted-by":"crossref","first-page":"378","DOI":"10.4103\/ijem.IJEM_36_17","article-title":"Growth hormone treatment in turner's syndrome: A real world experience","volume":"21","author":"Reddy Danda","year":"2017","journal-title":"Indian J Endocrinol Metab"},{"issue":"(Suppl 1)","key":"R8-20260302","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1007\/s13224-013-0411-5","article-title":"Turner syndrome: Fifteen years' experience in India","volume":"64","author":"Maiti","year":"2014","journal-title":"J Obstet Gynaecol India"},{"key":"R9-20260302","doi-asserted-by":"crossref","first-page":"249","DOI":"10.4103\/ijem.ijem_255_22","article-title":"Adult height in Indian girls with turner syndrome treated with long-term growth hormone therapy - a western India tertiary centre experience","volume":"27","author":"Khadilkar","year":"2023","journal-title":"Indian J Endocrinol Metab"},{"key":"R10-20260302","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1186\/s13633-018-0058-1","article-title":"Mode of clinical presentation and delayed diagnosis of Turner syndrome: A single Centre UK study","author":"Apperley","year":"2018","journal-title":"Int J Pediatr Endocrinol 2018"},{"key":"R11-20260302","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1136\/adc.2004.049817","article-title":"Belgian Study Group for Paediatric Endocrinology. 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