{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T17:20:47Z","timestamp":1787764847387,"version":"build-2784847793"},"reference-count":16,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"5","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2023,9]]},"abstract":"Abstract<\/jats:title>\n \n Background:<\/jats:title>\n It is estimated that in women at reproductive age, the risk of polycystic ovary syndrome (PCOS) is about 5\u201321%. In PCOS cases with ovulation dysfunction, assisted reproductive techniques (ART) are useful for infertility treatment.<\/jats:p>\n <\/jats:sec>\n \n Objective:<\/jats:title>\n This study aimed to evaluate the ART outcome in infertile PCOS women based on different testosterone levels. Finally, the relationships between testosterone in different levels and reproductive parameters including endocrine status, the response of ovaries, and pregnancy outcomes were assessed.<\/jats:p>\n <\/jats:sec>\n \n Methods:<\/jats:title>\n \n In this retrospective study, 352 infertile PCOS women were examined. The women were categorised into five groups according to their testosterone levels: A = T < 0.4, B = 0.4 < T > 0.6, C = 0.6 < T > 0.8, D = 0.8 < T > 1.0 and E = T > 1.0 ng\/dL. All study cases were in similar hyper-stimulation protocol and finally, hormonal profile and ART outcomes were compared between testosterone levels.\n P<\/jats:italic>\n value \u2264 0.05 was statistically significant.\n <\/jats:p>\n <\/jats:sec>\n \n Results:<\/jats:title>\n \n In testosterone levels >1.0, the levels of anti-mullerian hormone (AMH) and luteinising hormone (LH) were higher than in other testosterone level groups. AMH (\n P<\/jats:italic>\n = 0.05) and LH (\n P<\/jats:italic>\n = 0.001) levels showed significant differences. No correlation was present between testosterone levels and ART outcomes, including stimulation duration, endometrial thickness, oocyte numbers, numbers of matured oocytes, number of obtained embryos, fertilisation rate, implantation rate clinical pregnancy and abortion rate.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions:<\/jats:title>\n Serum testosterone levels did not show any correlation with pregnancy outcomes in ART cycles of PCOS. However, basal testosterone levels are a good predictor for ovarian reserve and ovarian response. Consequently, we suggest that some prospective studies must be designed to approve the role of testosterone in the prediction of the outcome of pregnancy in ART cycles.<\/jats:p>\n <\/jats:sec>","DOI":"10.4103\/ijem.ijem_360_22","type":"journal-article","created":{"date-parts":[[2023,10,30]],"date-time":"2023-10-30T04:25:43Z","timestamp":1698639943000},"page":"440-444","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":2,"title":["Ovarian Endocrine Status and ART 0utcomes in Women within PCOS Based on Different Testosterone Levels"],"prefix":"10.4103","volume":"27","author":[{"given":"Soudeh Khanamani","family":"Falahati-Pour","sequence":"first","affiliation":[{"name":"Pistachio Safety Research Center, Rafsanjan University of Medical Sciences, Rafsanjan, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Soheila","family":"Pourmasumi","sequence":"additional","affiliation":[{"name":"Social Determinants of Health Research Center, Rafsanjan University of Medical Sciences, Rafsanjan, Iran"},{"name":"Clinical Research Development Unit (CRDU), Ali-Ibn Abi-Talib Hospital, Rafsanjan University of Medical Sciences, Rafsanjan, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elham Sadat","family":"Mirhashemi","sequence":"additional","affiliation":[{"name":"Research and Clinical Center for Infertility, Yazd Reproductive Sciences Institute, Shahid Sadoughi University of Medical Sciences, Yazd, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2023,10,30]]},"reference":[{"key":"R1-20240828","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1007\/s10815-017-1047-7","article-title":"Polycystic ovary syndrome throughout a woman's life","volume":"35","author":"Bellver","year":"2018","journal-title":"J Assist Reprod Genet"},{"key":"R2-20240828","first-page":"11","article-title":"Is there any association between vitamin D levels and polycystic ovary syndrome (PCOS) phenotypes?","volume":"64","author":"Eftekhar","year":"2020","journal-title":"Arch Endocrinol Metab"},{"key":"R3-20240828","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1016\/j.cca.2015.08.019","article-title":"Testosterone, free testosterone, and free androgen index in women: Reference intervals, biological variation, and diagnostic value in polycystic ovary syndrome","volume":"450","author":"Bui","year":"2015","journal-title":"Clin Chim Acta"},{"key":"R4-20240828","doi-asserted-by":"crossref","first-page":"1149","DOI":"10.1016\/S0015-0282(00)00501-X","article-title":"Metformin therapy decreases hyperandrogenism and hyperinsulinemia in women with polycystic ovary syndrome","volume":"73","author":"Kolodziejczyk","year":"2000","journal-title":"Fertil Steril"},{"key":"R5-20240828","doi-asserted-by":"crossref","first-page":"3927","DOI":"10.1113\/JP277879","article-title":"Hyperandrogenism and insulin resistance-induced fetal loss: Evidence for placental mitochondrial abnormalities and elevated reactive oxygen species production in pregnant rats that mimic the clinical features of polycystic ovary syndrome","volume":"597","author":"Zhang","year":"2019","journal-title":"J Physiol"},{"key":"R6-20240828","doi-asserted-by":"crossref","first-page":"117","DOI":"10.3389\/fendo.2017.00117","article-title":"The distribution of stroma and antral follicles differs between insulin-resistance and hyperandrogenism-related polycystic ovarian syndrome. frontiers in endocrinology","volume":"8","author":"Alviggi","year":"2017","journal-title":"Front Endocrinol (Lausanne)"},{"key":"R7-20240828","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1016\/j.mce.2017.06.026","article-title":"Role of androgens in the ovary","volume":"465","author":"Walters","year":"2018","journal-title":"Mol Cell 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