{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T13:50:01Z","timestamp":1791640201154,"version":"4.3.4"},"reference-count":26,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","license":[{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-sa\/4.0"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction:<\/jats:title>\n                    <jats:p>Primary hyperparathyroidism (PHPT) is a common endocrine disorder with variable clinical presentation. We intend to describe the clinical, biochemical, and radio-pathological profiles of PHPT patients managed over 13 years from South India.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>We analysed all patients who underwent evaluation and surgery for PHPT from July 2011 to April 2024.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      A total of 862 PHPT patients underwent parathyroidectomy, with female preponderance (61.2%). Analysis was done on 804 patients (&gt;20 years of age) excluding adolescent and paediatric age groups. The mean age was 43.8 years. The presentation in decreasing order of frequency was weakness and fatigue (84.2%); bone pain (35%); renal disease (20.8%) in the form of nephrolithiasis, nephrocalcinosis, or renal dysfunction; and neuropsychiatric manifestations (23.8%). Pathological fractures were observed in 4.5%, hypercalcaemic crisis in 2.6% of patients, and 1% had MEN I (Multiple Endocrine Neoplasia) syndrome. The mean albumin adjusted serum calcium level was 12.3 \u00b1 1.01 mg\/dl, and the median serum PTH level was 338 (80\u20133864) pg\/ml. The sensitivity of the ultrasound neck and\n                      <jats:sup>99m<\/jats:sup>\n                      Tc Sestamibi scan was 97.5% and 98.3%, respectively, with a concordance of 93.4%. 25% underwent bilateral neck exploration and parathyroidectomy. Lesions were ectopic in 20 (2.4%) patients. The mean parathyroid gland weight was 1.45 \u00b1 0.75 g. Histopathology revealed parathyroid adenoma (93.5%), parathyroid hyperplasia (1.6%), and parathyroid carcinoma (2.2%). The cure rate was 99.3%, while three patients had persistent disease. Hungry bone syndrome was observed in 12.1%.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>There is a changing trend in the clinical and biochemical profiles of PHPT patients in India to a milder form of the disease. The incidence of parathyroid carcinoma was slightly higher compared to a few other centres in India.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/ijem.ijem_468_24","type":"journal-article","created":{"date-parts":[[2025,2,28]],"date-time":"2025-02-28T09:12:13Z","timestamp":1740733933000},"page":"69-76","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":5,"title":["Primary Hyperparathyroidism: Clinical, Biochemical, and Radio-Pathological Profiles of 804 Patients \u2013 A Retrospective Study from South India"],"prefix":"10.4103","volume":"29","author":[{"given":"Dhalapathy","family":"Sadacharan","sequence":"first","affiliation":[{"name":"Department of Endocrine Surgery, Rajiv Gandhi Government General Hospital, Madras Medical College, Chennai, Tamil Nadu, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mano Z.","family":"Mathews","sequence":"additional","affiliation":[{"name":"Department of Endocrine Surgery, Rajiv Gandhi Government General Hospital, Madras Medical College, Chennai, Tamil Nadu, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anjali","family":"Sathya","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Vijaya Group of Hospitals, Chennai, Tamil Nadu, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shanmugasundar","family":"Gopal","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Magna Centres for Obesity, Diabetes and Endocrinology, Chennai, Tamil Nadu, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sruti","family":"Chandrasekaran","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Dr. Rela Institute of Medical Centre, Chennai, Tamil Nadu, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sivasubramaniam","family":"Murthy","sequence":"additional","affiliation":[{"name":"Director and Consultant Endocrinologist, Endocrine Diagnostic and Research Centre, Chennai, Tamil Nadu, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vijaya B.","family":"Reddy","sequence":"additional","affiliation":[{"name":"Director and Consultant Endocrinolgist, Vijay Daibetes, Thyroid and Endocrine Clinic, Puducherry, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jayashree","family":"Gopal","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, DiabEndoIndia and Apollo Hospitals, Chennai, Tamil Nadu, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muthukumaran","family":"Jeyapaul","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Arka Center for Hormonal Health, Chennai, Tamil Nadu, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sakthivel","family":"Sivasubramanian","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, The Hormone Clinic, Trichy, Tamil Nadu, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vignesh","family":"Gopalakrishnan","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Dr. Vignesh\u2019s Endocrine and Diabetes Centre, Trichy, Tamil Nadu, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bharath","family":"Ramji","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Arka Center for Hormonal Health, Chennai, Tamil Nadu, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dinesh","family":"Goli","sequence":"additional","affiliation":[{"name":"Department of Endocrine Surgery, Rajiv Gandhi Government General Hospital, Madras Medical College, Chennai, Tamil Nadu, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gokulakrishnan","family":"Sundararaman","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Billroth Hospital, RA Puram, Chennai, Tamil Nadu, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shriraam","family":"Mahadevan","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Diabetes and Metabolism, Sri Ramachandra Institute of Higher Education and Research, Porur, Chennai, Tamil Nadu, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2025,2,28]]},"reference":[{"key":"R1-20250228","doi-asserted-by":"crossref","first-page":"1122","DOI":"10.1210\/jc.2012-4022","article-title":"Incidence and prevalence of primary hyperparathyroidism in a racially mixed population","volume":"98","author":"Yeh","year":"2013","journal-title":"J Clin Endocrinol Metab"},{"key":"R2-20250228","doi-asserted-by":"crossref","first-page":"221","DOI":"10.3897\/folmed.66.e117637","article-title":"Emerging pattern of asymptomatic hyperparathyroidism in South India-A six-year retrospective 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