{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T20:37:17Z","timestamp":1786739837066,"version":"build-2736575974"},"reference-count":35,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"2","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2021,3]]},"abstract":"<jats:sec>\n                    <jats:title>Purpose of the Study:<\/jats:title>\n                    <jats:p>Reversible proximal tubular dysfunction associated with distal renal tubular acidosis (dRTA) mimics type 3 RTA, a condition classically associated with features of both proximal RTA (pRTA) and dRTA. Proximal tubulopathy has been reported in children with primary dRTA, but the data in adults are lacking.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Study Design:<\/jats:title>\n                    <jats:p>In this hospital record-based retrospective study, data from 66 consecutive cases of RTA, between January 2016 to December 2018, were retrieved and analyzed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>Mean age of the study population was 25.3 years (range: 3 months to 73 years). Six (9.1%) of them had pRTA, 58 (87.9%) had dRTA, 1 (1.5%) had type 3 RTA, and the remaining 1 (1.5%) had type 4 RTA. Ten patients (17.2%) with dRTA and 3 patients of pRTA (50%) had underlying secondary etiologies. Data on proximal tubular dysfunction were available for 30 patients with dRTA, of whom 1 had isolated dRTA, and the rest 29 patients had accompanying completely reversible proximal tubular dysfunction. Among the 10 cases of secondary dRTA, 6 were not evaluated for proximal tubular dysfunction. Of the remaining 4, 3 had reversible form of proximal tubular abnormality. Fifty-two patients with dRTA came from a population, indigenous to the \u201cRarh\u201d region of India.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>Proximal tubular dysfunction often accompanies dRTA; 75% of the children with primary dRTA, at least 29% of adults with primary dRTA, and at least 30% of adults with secondary dRTA manifest such completely reversible form of proximal tubulopathy. \u201cRarh\u2019 region of India probably is a hotspot for endemic dRTA.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/ijem.ijem_785_20","type":"journal-article","created":{"date-parts":[[2021,9,8]],"date-time":"2021-09-08T05:20:50Z","timestamp":1631078450000},"page":"121-128","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":5,"title":["Clinical and Biochemical Characteristics of Patients with Renal Tubular Acidosis in Southern Part of West Bengal, India"],"prefix":"10.4103","volume":"25","author":[{"given":"Partha Pratim","family":"Chakraborty","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rana","family":"Bhattacharjee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shinjan","family":"Patra","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ajitesh","family":"Roy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kripasindhu","family":"Gantait","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Subhankar","family":"Chowdhury","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R1-8-20240828","doi-asserted-by":"crossref","first-page":"987","DOI":"10.1007\/s00467-016-3573-4","article-title":"Clinical and molecular aspects of distal renal tubular acidosis in children","volume":"32","author":"Besouw","year":"2017","journal-title":"Pediatr Nephrol"},{"key":"R2-8-20240828","doi-asserted-by":"crossref","first-page":"604","DOI":"10.1159\/000188947","article-title":"Prevalence of endemic distal renal tubular acidosis and renal stone in the northeast of Thailand","volume":"72","author":"Nimmannit","year":"1996","journal-title":"Nephron"},{"key":"R3-8-20240828","doi-asserted-by":"crossref","first-page":"397","DOI":"10.4103\/ijem.IJEM_633_17","article-title":"Etiological search and epidemiological profile in patients presenting with hypokalemic paresis:An observational study","volume":"22","author":"Patra","year":"2018","journal-title":"Indian J Endocrinol Metab"},{"key":"R5-8-20240828","doi-asserted-by":"crossref","first-page":"682","DOI":"10.1053\/j.ajkd.2019.03.427","article-title":"Physiology and pathophysiology of potassium homeostasis:Core Curriculum 2019","volume":"74","author":"Palmer","year":"2019","journal-title":"Am J Kidney Dis"},{"key":"R6-8-20240828","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1016\/S0140-6736(75)92736-1","article-title":"Nomogram for derivation of renal threshold phosphate concentration","volume":"2","author":"Walton","year":"1975","journal-title":"Lancet"},{"key":"R8-8-20240828","first-page":"23","article-title":"Non-azotemic refractory rickets in Indian children","volume":"42","author":"Bajpai","year":"2005","journal-title":"Indian Pediatr"},{"key":"R9-8-20240828","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1007\/s12098-020-03318-8","article-title":"Renal tubular acidosis","volume":"87","author":"Bagga","year":"2020","journal-title":"Indian J Pediatr"},{"key":"R10-8-20240828","first-page":"246","article-title":"Aetiological, clinical and metabolic profile of hypokalaemic periodic paralysis in adults:A single-centre experience","volume":"19","author":"Rao","year":"2006","journal-title":"Natl Med J India"},{"key":"R11-8-20240828","doi-asserted-by":"crossref","first-page":"211","DOI":"10.4103\/0972-2327.112469","article-title":"Clinical and biochemical spectrum of hypokalemic paralysis in North:East India","volume":"16","author":"Kayal","year":"2013","journal-title":"Ann Indian Acad Neurol"},{"key":"R12-8-20240828","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1159\/000365199","article-title":"Renal tubular acidosis in Sj\u00f6gren's syndrome:A case series","volume":"40","author":"Ram","year":"2014","journal-title":"Am J Nephrol"},{"key":"R13-8-20240828","doi-asserted-by":"crossref","first-page":"114","DOI":"10.2174\/1874312901812010114","article-title":"Sj\u00f6gren's, renal tubular acidosis and osteomalacia - 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