{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T03:10:26Z","timestamp":1789096226365,"version":"build-2803163510"},"reference-count":18,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"4","license":[{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2026,7]]},"abstract":"Abstract<\/jats:title>\n \n Introduction:<\/jats:title>\n Klotho, an anti-ageing protein involved in metabolic regulation, is downregulated in type 2 diabetes mellitus (T2DM). Prior studies suggest that enhancing Klotho expression may help manage diabetes and its complications. Yoga, with its systemic effects, may offer a promising non-pharmacological approach. The present study aimed to evaluate the effect of a 15-day structured yoga lifestyle (SYL) programme on serum Klotho levels and glycaemic parameters in individuals with T2DM.<\/jats:p>\n <\/jats:sec>\n \n Methods:<\/jats:title>\n This single-arm, open-label exploratory study was conducted on 74 adults (30\u201365 years) with T2DM. The SYL programme included asanas, pranayama, meditation, kriyas, a satvik diet, and spiritual sessions. Pre- and post-assessments included serum Klotho, fasting blood glucose (FBG), postprandial blood glucose (PPBG), and blood pressure (BP). The Wilcoxon signed-rank test was used.<\/jats:p>\n <\/jats:sec>\n \n Results:<\/jats:title>\n \n Serum Klotho levels increased significantly by 14.65% (\n P<\/jats:italic>\n < 0.001). FBG and PPBG were reduced by 5.97% and 3.68%, respectively (\n P<\/jats:italic>\n < 0.001). Systolic BP was reduced modestly (\n P<\/jats:italic>\n = 0.025); diastolic BP showed no change. Subgroup analysis showed greater Klotho increase in those aged > 55 years, females, non-hypertensives, and those with a longer duration of diabetes (\n P<\/jats:italic>\n < 0.05).\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion:<\/jats:title>\n The findings support SYL as a potential adjunct therapy. Longer controlled trials are needed to further establish these results.<\/jats:p>\n <\/jats:sec>","DOI":"10.4103\/ijem.ijem_831_25","type":"journal-article","created":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T17:01:51Z","timestamp":1788195711000},"page":"302-305","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":0,"title":["Impact of a Short-term Yoga Lifestyle Programme on Circulating Serum Klotho Levels in Patients with Type 2 Diabetes: An Exploratory Study"],"prefix":"10.4103","volume":"30","author":[{"given":"Atmakur","family":"Snigdha","sequence":"first","affiliation":[{"name":"Division of Yoga and Life Science, Swami Vivekananda Yoga Anusandhana Samsthana (SVYASA), Bengaluru, Karnataka, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vijaya","family":"Majumdar","sequence":"additional","affiliation":[{"name":"Division of Yoga and Life Science, Swami Vivekananda Yoga Anusandhana Samsthana (SVYASA), Bengaluru, Karnataka, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kalpana S.","family":"Ramegowda","sequence":"additional","affiliation":[{"name":"Department of Pathology, Sri Jayadeva Institute of Cardiovascular Sciences and Research, Bengaluru, Karnataka, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2026,8,31]]},"reference":[{"key":"R1-20260911","doi-asserted-by":"crossref","first-page":"2932","DOI":"10.4103\/ijo.IJO_1627_21","article-title":"Epidemiology of type 2 diabetes in India","volume":"69","author":"Pradeepa","year":"2021","journal-title":"Indian J Ophthalmol"},{"key":"R3-20260911","doi-asserted-by":"crossref","first-page":"e41933","DOI":"10.2196\/41933","article-title":"Challenges of type 2 diabetes mellitus management from the perspective of patients: Conventional content analysis","volume":"11","author":"Nikpour","year":"2022","journal-title":"Interact J Med 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