{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T13:19:15Z","timestamp":1787750355623,"version":"build-2784847793"},"reference-count":23,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"3","license":[{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction:<\/jats:title>\n                    <jats:p>Omentin-1 is an adipocytokine predominantly secreted by visceral adipose tissue and associated with insulin sensitivity. Altered levels of omentin-1 in type 2 diabetes mellitus (T2DM) and obesity denote a potential link with insulin resistance.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>\n                      Two hundred twenty-five adult males with T2DM were segregated into non-obese (\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      = 75), overweight (\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      = 75), and obese (\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      = 75) groups. Anthropometric, haemodynamic, and biochemical parameters, including glucose, insulin, lipid profile, and omentin-1 were measured. Insulin resistance was assessed using validated surrogate indices. Group comparisons were performed and associations were examined using correlation analysis and a prespecified multivariable linear regression model.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      Obese subjects had higher BMI, waist-to-hip ratio, fasting glucose, HbA1c, fasting insulin, HOMA-IR, lipid fractions, and METS-IR as compared to non-obese. Serum omentin-1 levels declined progressively with increasing adiposity [non-obese 687.6 (654.1\u2013763.2), overweight 587.6 (548.6\u2013658.1), obese 459.3 (398.7\u2013524.8) ng\/L;\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; 0.001]. Omentin-1 showed inverse correlations with BMI (\u03b3 = \u22120.703), waist-to-hip ratio (\u03b3 = \u22120.717), HOMA-IR (\u03b3 = \u22120.403), triglyceride-BMI index (\u03b3 = \u22120.695), and LDL-cholesterol (\u03b3 = \u22120.417), and a positive correlation with QUICKI (\u03b3 =0.403; all\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; 0.001). In the multivariable model, LDL-cholesterol remained independently associated with circulating omentin-1 levels (\u03b2 =2.527,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.043).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Serum omentin-1 shows an inverse association with adiposity, insulin resistance, and lipid parameters in T2DM, suggesting that omentin-1 could serve as a potential marker of an adverse cardiometabolic profile, although comprehensive studies are further warranted.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/ijem.ijem_934_25","type":"journal-article","created":{"date-parts":[[2026,6,26]],"date-time":"2026-06-26T14:01:51Z","timestamp":1782482511000},"page":"211-216","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":0,"title":["Circulating Omentin-1 Across BMI Categories in Type 2 Diabetes and its Association with Insulin Resistance: A Cross-Sectional Study from South India"],"prefix":"10.4103","volume":"30","author":[{"given":"Saidaiah","family":"Ikkurthi","sequence":"first","affiliation":[{"name":"Department of Biochemistry, All India Institute of Medical Sciences, Mangalagiri, Andhra Pradesh, India"},{"name":"Department of Biochemistry, Mahatma Gandhi Medical College and Research Institute, Sri Balaji Vidyapeeth, Puducherry, Puducherry, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. R.","family":"Srinivasan","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, Mahatma Gandhi Medical College and Research Institute, Sri Balaji Vidyapeeth, Puducherry, Puducherry, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vaikkakara","family":"Suresh","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, All India Institute of Medical Sciences, Mangalagiri, Andhra Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rajendran","family":"Jayanthi","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, Mahatma Gandhi Medical College and Research Institute, Sri Balaji Vidyapeeth, Puducherry, Puducherry, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vidya S.","family":"Desai","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, All India Institute of Medical Sciences, Mangalagiri, Andhra Pradesh, 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