{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T18:33:31Z","timestamp":1790966011928,"version":"4.1.0"},"reference-count":35,"publisher":"Scientific Scholar","issue":"1","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2023,7]]},"abstract":"\n Background & objectives:<\/jats:title>\n Celiac disease (CD) is a genetic immune mediated disorder characterised by gluten intolerance. This single centre study, from north India was aimed to assess the clinical, serological and histological profile of CD in a large cohort of children and the changing trends in its presentation.<\/jats:p>\n <\/jats:sec>\n \n Methods:<\/jats:title>\n A review of clinical details of CD children diagnosed between 2000 and 2019 and currently on follow up was performed. Information on demography, symptoms, associated conditions, serology, biopsy findings and gluten-free diet were analyzed.<\/jats:p>\n <\/jats:sec>\n \n Results:<\/jats:title>\n The mean age (\u00b1standard deviation) of 891 children included in the study, at onset and at diagnosis was 4.0\u00b12.7 and 6.2\u00b13.1 yr, respectively. Growth faltering, abdominal pain, abdominal distension and diarrhoea were presenting symptoms in 70, 64.2, 61.2 and 58.2 per cent, respectively. A positive family history of CD was present in 14 per cent and autoimmune conditions in 12.3 per cent of children. Thyroid disorders were seen in 8.5 per cent of children and Type 1 diabetes mellitus (T1DM) in 5.7 per cent. The duration of breastfeeding had a weak positive correlation with age at onset and diagnosis of CD (P<\/jats:italic><0.001). Non-classical CD was significantly more common in children aged >10 yr and in those presenting after 2010 (P<\/jats:italic><0.01). T1DM and hypothyroidism occurred more frequently in non-compliant children.<\/jats:p>\n <\/jats:sec>\n \n Interpretation & conclusions:<\/jats:title>\n This was the largest single centre study, pertaining to the presentation and follow up of CD in children. Infants and young children were more likely to present with classical symptoms of diarrhoea, abdominal distension and growth failure while older children presented with non-classical CD. There was a trend towards non-classical forms of CD in recent years.<\/jats:p>\n <\/jats:sec>","DOI":"10.4103\/ijmr.ijmr_1102_21","type":"journal-article","created":{"date-parts":[[2023,8,7]],"date-time":"2023-08-07T02:31:54Z","timestamp":1691375514000},"page":"75-84","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":8,"title":["Clinical spectrum & changing presentation of celiac disease in Indian children"],"prefix":"10.25259","volume":"158","author":[{"given":"Sadhna Bhasin","family":"Lal","sequence":"first","affiliation":[{"name":"Division of Paediatric Gastroenterology & Hepatology, Postgraduate Institute of Medical Education & Research, Chandigarh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vybhav","family":"Venkatesh","sequence":"additional","affiliation":[{"name":"Division of Paediatric Gastroenterology & Hepatology, Postgraduate Institute of Medical Education & Research, Chandigarh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aradhana","family":"Aneja","sequence":"additional","affiliation":[{"name":"Division of Paediatric Gastroenterology & Hepatology, Postgraduate Institute of Medical Education & Research, Chandigarh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keerthivasan","family":"Seetharaman","sequence":"additional","affiliation":[{"name":"Division of Paediatric Gastroenterology & Hepatology, Postgraduate Institute of Medical Education & Research, Chandigarh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yashwant","family":"Kumar","sequence":"additional","affiliation":[{"name":"Department of Immunopathology, Postgraduate Institute of Medical Education & Research, Chandigarh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaushal Kishor","family":"Prasad","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology Histopathology, Postgraduate Institute of Medical Education & Research, Chandigarh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Surinder Singh","family":"Rana","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Postgraduate Institute of Medical Education & Research, Chandigarh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"10894","published-online":{"date-parts":[[2023,8,11]]},"reference":[{"key":"R1-20241212","doi-asserted-by":"crossref","first-page":"6028","DOI":"10.3748\/wjg.15.6028","article-title":"Indian task force for celiac disease: Current status","volume":"15","author":"Gupta","year":"2009","journal-title":"World J Gastroenterol"},{"key":"R2-20241212","doi-asserted-by":"crossref","first-page":"2517","DOI":"10.1056\/NEJMoa021687","article-title":"Prevalence of Celiac disease among children in Finland","volume":"348","author":"M\u00e4ki","year":"2003","journal-title":"N Engl J Med"},{"key":"R3-20241212","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1016\/S0140-6736(99)00243-3","article-title":"An iceberg of childhood coeliac disease in the Netherlands","volume":"353","author":"Csizmadia","year":"1999","journal-title":"Lancet"},{"key":"R4-20241212","doi-asserted-by":"crossref","first-page":"1622","DOI":"10.1111\/j.1440-1746.2006.04281.x","article-title":"Prevalence of celiac disease among school children in Punjab, North India","volume":"21","author":"Sood","year":"2006","journal-title":"J Gastroenterol Hepatol"},{"key":"R5-20241212","doi-asserted-by":"crossref","first-page":"823","DOI":"10.1016\/j.cgh.2017.06.037","article-title":"Global prevalence of celiac disease: Systematic review and meta-analysis","volume":"16","author":"Singh","year":"2018","journal-title":"Clin Gastroenterol Hepatol"},{"key":"R6-20241212","first-page":"415","article-title":"Prevalence of celiac disease in north Indian children","volume":"46","author":"Bhattacharya","year":"2009","journal-title":"Indian Pediatr"},{"key":"R7-20241212","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1097\/01.mpg.0000231589.32114.9d","article-title":"Clinical features of celiac disease in Indian children: Are they different from the West?","volume":"43","author":"Poddar","year":"2006","journal-title":"J Pediatr Gastroenterol Nutr"},{"key":"R8-20241212","doi-asserted-by":"crossref","first-page":"909","DOI":"10.1136\/adc.65.8.909","article-title":"Revised criteria for diagnosis of coeliac disease. 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