{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T15:35:57Z","timestamp":1793115357815,"version":"4.5.0"},"reference-count":58,"publisher":"Scientific Scholar","issue":"5&6","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2023,11]]},"abstract":"<jats:p>Incidence of cervical cancer and associated mortality are still high in resource-constrained countries due to the lack of infrastructural facilities and trained workforce. Human papillomavirus (HPV)-based screening tests offer a better sensitivity (&gt;90%) for the detection of cervical high-grade lesions. However, these tests usually require an extensive laboratory set-up and trained technical staff. Moreover, the high cost of the currently available and approved HPV tests precludes their use in the cervical cancer screening programmes in resource-limited settings. Hence, there is a felt need for a low-cost point-of-care (POC) HPV test with good performance characteristics to help augment cervical cancer screening in such settings. A recent meta-analysis demonstrated a good sensitivity and specificity for two of the commercially available POC HPV tests. The present review discusses the merits and limitations of the current commercially available POC and near-POC devices for HPV-based cervical cancer screening. The technologies that have the potential to be developed into low-cost POC tests and newer promising modalities for HPV-based POC or near POC have also been highlighted. This review underscores the need for collaborative and coordinated research for development of POC or near-POC HPV-based tests to be used in cervical cancer screening. Efforts need to be focussed on technologies that offer ease of performance without the requirement of sophisticated equipment or extensive sample pre-processing coupled with a good sensitivity and cost-effectiveness.<\/jats:p>","DOI":"10.4103\/ijmr.ijmr_1143_23","type":"journal-article","created":{"date-parts":[[2024,4,9]],"date-time":"2024-04-09T09:32:47Z","timestamp":1712655167000},"page":"509-521","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":19,"title":["Point-of-care tests for human papillomavirus detection in uterine cervical samples: A review of advances in resource-constrained settings"],"prefix":"10.25259","volume":"158","author":[{"given":"Ruchika","family":"Gupta","sequence":"first","affiliation":[{"name":"Division of Cytopathology, ICMR-National Institute for Cancer Prevention and Research, Noida, Uttar Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sanjay","family":"Gupta","sequence":"additional","affiliation":[{"name":"Division of Cytopathology, ICMR-National Institute for Cancer Prevention and Research, Noida, Uttar Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"10894","published-online":{"date-parts":[[2024,1,24]]},"reference":[{"key":"R1-20241212","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1002\/ijc.24322","article-title":"Molecular variants of HPV-16 associated with cervical cancer in Indian population","volume":"125","author":"Pillai","year":"2009","journal-title":"Int J Cancer"},{"key":"R2-20241212","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1016\/j.jasc.2019.06.001","article-title":"A review of the FDA-approved molecular testing platforms for human papillomavirus","volume":"8","author":"Salazar","year":"2019","journal-title":"J Am Soc Cytopathol"},{"key":"R3-20241212","doi-asserted-by":"crossref","first-page":"105237","DOI":"10.1016\/j.jcv.2022.105237","article-title":"Improving human papillomavirus (HPV) testing in the cervical cancer elimination era:The 2021 HPV LabNet international proficiency study","volume":"154","author":"Arroyo M\u00fchr","year":"2022","journal-title":"J Clin Virol"},{"key":"R4-20241212","doi-asserted-by":"crossref","first-page":"e0001982","DOI":"10.1371\/journal.pgph.0001982","article-title":"Toward 70% cervical cancer screening coverage:Technical challenges and opportunities to increase access to human papillomavirus (HPV) testing","volume":"3","author":"Kundrod","year":"2023","journal-title":"PLOS Glob Public Health"},{"key":"R5-20241212","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1136\/sti.2004.011858","article-title":"Diagnostic accuracy of self collected vaginal specimens for human papillomavirus compared to clinician collected human papillomavirus specimens:A meta-analysis","volume":"81","author":"Ogilvie","year":"2005","journal-title":"Sex Transm Infect"},{"key":"R6-20241212","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1016\/j.ygyno.2022.06.012","article-title":"Accuracy of HPV testing on self-collected and clinician-collected samples for different screening strategies in African settings:A systematic review and meta-analysis","volume":"166","author":"Sy","year":"2022","journal-title":"Gynecol Oncol"},{"key":"R7-20241212","doi-asserted-by":"crossref","first-page":"e0243036","DOI":"10.1371\/journal.pone.0243036","article-title":"Community cervical cancer screening:Barriers to successful home-based HPV self-sampling in Dabat district, North Gondar, Ethiopia. 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