{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,17]],"date-time":"2025-12-17T18:14:20Z","timestamp":1765995260228,"version":"3.41.0"},"reference-count":14,"publisher":"Scientific Scholar","issue":"4","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2023,10]]},"abstract":"\n Background & objectives:<\/jats:title>\n The World Health Organization (WHO) has endorsed thermal ablation (thermocoagulation) as an efficient and safe modality for treatment of cervical pre-cancer lesions. More evidence is being looked up by WHO through rigorous studies for health delivery models using screen-and-treat strategies incorporating thermal ablation and studies comparing it against the conventional standard modality cryotherapy. The objective of this study was to assess the acceptability of thermal ablation both among the providers and clients and compare the same with cryotherapy.<\/jats:p>\n <\/jats:sec>\n \n Methods:<\/jats:title>\n A randomized control trial was conducted for one year from September 2019 to October 2020 after obtaining ethics approval. Computer-generated random number table was used for randomization, and eligible candidates were divided into two groups following informed consent. Women with visual inspection with acetic acid (VIA) positive cervical lesions in Group A received cryotherapy and Group B received thermal ablation. After the procedure, the acceptability of the provider and the client were assessed using the International Agency for Research on Cancer-validated questionnaire for both the procedures. Immediate side effects and problems at six weeks and at six months were assessed as well. Efficacy was decided by the absence of VIA positivity at six months.<\/jats:p>\n <\/jats:sec>\n \n Results:<\/jats:title>\n The overall VIA positivity in this study was 11.8 per cent. Thermal ablation (thermocoagulation) had better provision and client acceptability than cryotherapy (significant difference). The efficacy of thermal ablation was 97.6 per cent, while, it was 92 per cent for cryotherapy (not significant).<\/jats:p>\n <\/jats:sec>\n \n Interpretation & conclusions:<\/jats:title>\n In the context of screen-and-treat programme in settings such as India, thermal ablation appears to be a better method of treatment than cryotherapy for cervical pre-cancerous lesions particularly in terms of better provision and client acceptability.<\/jats:p>\n <\/jats:sec>","DOI":"10.4103\/ijmr.ijmr_1166_22","type":"journal-article","created":{"date-parts":[[2023,11,28]],"date-time":"2023-11-28T04:11:04Z","timestamp":1701144664000},"page":"423-431","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":2,"title":["Comparison of acceptability & efficacy of thermal ablation (thermocoagulation) & cryotherapy in VIA positive cervical lesions: A pilot study"],"prefix":"10.25259","volume":"158","author":[{"given":"Manju Lata","family":"Verma","sequence":"first","affiliation":[{"name":"Department of Obstetrics & Gynaecology, King George\u2019s Medical University, Lucknow, Uttar Pradesh, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Parul","family":"Sharma","sequence":"additional","affiliation":[{"name":"Department of Obstetrics & Gynaecology, King George\u2019s Medical University, Lucknow, Uttar Pradesh, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Uma","family":"Singh","sequence":"additional","affiliation":[{"name":"Department of Obstetrics & Gynaecology, King George\u2019s Medical University, Lucknow, Uttar Pradesh, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rekha","family":"Sachan","sequence":"additional","affiliation":[{"name":"Department of Obstetrics & Gynaecology, King George\u2019s Medical University, Lucknow, Uttar Pradesh, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pushp Lata","family":"Sankhwar","sequence":"additional","affiliation":[{"name":"Department of Obstetrics & Gynaecology, King George\u2019s Medical University, Lucknow, Uttar Pradesh, India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"10894","published-online":{"date-parts":[[2023,9,25]]},"reference":[{"key":"R1-20241212","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1016\/j.bpobgyn.2011.08.003","article-title":"Visual inspection methods for cervical cancer prevention","volume":"26","author":"Sankaranarayanan","year":"2012","journal-title":"Best Pract Res Clin Obstet Gynaecol"},{"key":"R2-20241212","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1016\/S0140-6736(07)61171-4","article-title":"Cervical screening by visual inspection with acetic acid","volume":"370","author":"Szarewski","year":"2007","journal-title":"Lancet"},{"key":"R3-20241212","first-page":"869","article-title":"University of Zimbabwe\/JHPIEGO cervical cancer 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Malawi","volume":"139","author":"Campbell","year":"2016","journal-title":"Int J Cancer"},{"key":"R15-20241212","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1634\/theoncologist.18-S2-6","article-title":"Screen-and-treat approach to cervical cancer prevention using visual inspection with acetic acid and cryotherapy:Experiences, perceptions, and beliefs from demonstration projects in Peru, Uganda, and Vietnam","volume":"18","author":"Paul","year":"2013","journal-title":"Oncologist"},{"key":"R16-20241212","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1016\/j.ijgo.2015.09.035","article-title":"Efficacy, safety, and acceptability of thermocoagulation for treatment of cervical intraepithelial neoplasia in a hospital setting in Brazil","volume":"133","author":"Naud","year":"2016","journal-title":"Int J Gynaecol Obstet"},{"key":"R17-20241212","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/j.ypmed.2018.10.006","article-title":"Worthy of further consideration:An updated meta-analysis to address the feasibility, acceptability, safety and efficacy of thermal ablation in the treatment of cervical cancer precursor lesions","volume":"118","author":"Randall","year":"2019","journal-title":"Prev Med"},{"key":"R18-20241212","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1186\/s12905-016-0355-x","article-title":"Feasibility of thermocoagulation in a screen-and-treat approach for the treatment of cervical precancerous lesions in sub-Saharan Africa","volume":"17","author":"Viviano","year":"2017","journal-title":"BMC Womens Health"},{"key":"R19-20241212","doi-asserted-by":"crossref","first-page":"929","DOI":"10.1111\/1471-0528.12655","article-title":"Meta-analysis of the efficacy of cold coagulation as a treatment method for cervical intraepithelial neoplasia:A systematic review","volume":"121","author":"Dolman","year":"2014","journal-title":"BJOG"}],"container-title":["Indian Journal of Medical 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