{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T11:08:52Z","timestamp":1783508932159,"version":"3.55.0"},"reference-count":28,"publisher":"Scientific Scholar","issue":"5","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2019,5]]},"abstract":"\n Background & objectives:<\/jats:title>\n Limited data are available on the typing of Chlamydia trachomatis<\/jats:italic> in India. Serovars D to K of C. trachomatis<\/jats:italic> are chiefly responsible for urogenital infections. Thus, this study was conducted to determine the distribution of C. trachomatis<\/jats:italic> serovars in patients with urogenital infections and to characterize omp<\/jats:italic>A gene of the detected C. trachomatis<\/jats:italic> isolates by sequence analysis. Presence of other co-infections was also evaluated.<\/jats:p>\n <\/jats:sec>\n \n Methods:<\/jats:title>\n Endocervical swabs were collected from 324 women and urethral swabs\/urine were collected from 193 men attending the sexually transmitted diseases outpatient clinic. The samples were screened for C. trachomatis<\/jats:italic> by cryptic plasmid PCR and omp<\/jats:italic>A gene PCR. Genotyping was performed by PCR-restriction fragment length polymorphism (RFLP) and sequencing of the omp<\/jats:italic>A gene. Samples were screened for genital mycoplasmas, Neisseria gonorrhoeae<\/jats:italic>, Treponema pallidum<\/jats:italic> and human immunodeficiency virus (HIV).<\/jats:p>\n <\/jats:sec>\n \n Results:<\/jats:title>\n \n C. trachomatis<\/jats:italic> was found in 15.0 per cent men and 10.8 per cent women. Serovar D was the most prevalent followed by serovars E, F, I and G. Twenty two C. trachomatis<\/jats:italic> isolates were selected for omp<\/jats:italic>A gene sequencing. No mixed infection was found. Variability in omp<\/jats:italic>A sequences was seen in 31.8 per cent cases. Both PCR-RFLP and omp<\/jats:italic>A gene sequencing showed concordant results. The presence of Ureaplasma<\/jats:italic> spp. and Mycoplasma hominis<\/jats:italic> was observed in 18.7 and 9.5 per cent patients, respectively. Co-infection of C. trachomatis<\/jats:italic> was significantly associated with Ureaplasma urealyticum<\/jats:italic> and HIV.<\/jats:p>\n <\/jats:sec>\n \n Interpretation & conclusions:<\/jats:title>\n The high occurence of C. trachomatis<\/jats:italic> infections warrants its screening in addition to other sexually transmitted infections namely U. urealyticum<\/jats:italic> and HIV. Genotyping of the omp<\/jats:italic>A gene may provide additional information for vaccine development.<\/jats:p>\n <\/jats:sec>","DOI":"10.4103\/ijmr.ijmr_1171_17","type":"journal-article","created":{"date-parts":[[2019,8,21]],"date-time":"2019-08-21T07:29:56Z","timestamp":1566372596000},"page":"662-670","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":16,"title":["Distribution of Chlamydia trachomatis ompA genotypes in patients attending a sexually transmitted disease outpatient clinic in New Delhi, India"],"prefix":"10.25259","volume":"149","author":[{"given":"Jyoti","family":"Rawre","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benu","family":"Dhawan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neena","family":"Khanna","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vishnubhatla","family":"Sreenivas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shobha","family":"Broor","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rama","family":"Chaudhry","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"10894","reference":[{"key":"R1-14-20241212","first-page":"1","article-title":"Centers for Disease Control and Prevention, Sexually transmitted diseases treatment 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