{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T02:43:50Z","timestamp":1790045030660,"version":"4.0.1"},"reference-count":12,"publisher":"Scientific Scholar","issue":"1","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2019,1]]},"abstract":"\n Background & objectives:<\/jats:title>\n The fluoroquinolones (FQs) group of antibiotics is the backbone drugs for the management of drug-resistant tuberculosis (TB). In routine clinical practice, drug susceptibility testing (DST) for FQs is not performed, and the patients are empirically treated. A limited information exists regarding FQs resistance among pulmonary TB cases. The present study was conducted to determine the FQs resistance among drug sensitive and drug-resistant pulmonary TB patients in a tertiary care centre in north India.<\/jats:p>\n <\/jats:sec>\n \n Methods:<\/jats:title>\n A total of 1619 sputum\/smear-positive specimens of pulmonary TB patients were subjected to DST for first-line drugs (FLDs) and second-line drugs. In addition, FQs DST was also performed using automated Mycobacterial Growth Indicator Tube-960 liquid culture technique. The immuno-chromatographic assay was performed to distinguish Mycobacterium tuberculosis<\/jats:italic> complex (MTBC) from non-MTBC.<\/jats:p>\n <\/jats:sec>\n \n Results:<\/jats:title>\n Mycobacterium tuberculosis (Mtb) was isolated in 1499 sputum specimens; 1099 culture specimens were sensitive to FLDs, 249 grew as multidrug-resistant (MDR) Mtb<\/jats:italic> and the remaining 151 isolates revealed any drug resistance to FLDs. While FQs monoresistance among the FLD sensitive isolates was 3.1 per cent (35\/1099), 27.3 per cent (68\/249) among MDR Mtb<\/jats:italic> isolates had additional FQs resistance.<\/jats:p>\n <\/jats:sec>\n \n Interpretation & conclusions:<\/jats:title>\n FQs resistance among drug sensitive and MDR Mtb<\/jats:italic> isolates was high in Delhi, India. Based on these findings, it is recommended that the DST for FQs should be routinely performed to avoid further amplification of drug resistance.<\/jats:p>\n <\/jats:sec>","DOI":"10.4103\/ijmr.ijmr_1220_17","type":"journal-article","created":{"date-parts":[[2019,4,22]],"date-time":"2019-04-22T05:51:35Z","timestamp":1555912295000},"page":"62-66","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":23,"title":["High degree of fluoroquinolone resistance among pulmonary tuberculosis patients in New Delhi, India"],"prefix":"10.25259","volume":"149","author":[{"given":"Rohini","family":"Sharma","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Surendra Kumar","family":"Sharma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Binit Kumar","family":"Singh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abhenil","family":"Mittal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Prahlad","family":"Kumar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"10894","reference":[{"key":"R2-11-20241212","doi-asserted-by":"crossref","first-page":"903","DOI":"10.1136\/thx.2005.056887","article-title":"Empirical treatment with a fluoroquinolone delays the treatment for tuberculosis and is associated with a poor prognosis in endemic areas","volume":"61","author":"Wang","year":"2006","journal-title":"Thorax"},{"key":"R3-11-20241212","first-page":"79","article-title":"Increasing incidence of fluoroquinolone-resistant Mycobacterium tuberculosis in Mumbai, India","volume":"13","author":"Agrawal","year":"2009","journal-title":"Int J Tuberc Lung Dis"},{"key":"R4-11-20241212","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1016\/j.tube.2012.05.010","article-title":"Pre-XDR & XDR in MDR and ofloxacin and kanamycin resistance in non-MDR Mycobacterium tuberculosis isolates","volume":"92","author":"Jain","year":"2012","journal-title":"Tuberculosis (Edinb"},{"key":"R8-11-20241212","doi-asserted-by":"crossref","first-page":"1977","DOI":"10.1056\/NEJM200311133492023","article-title":"The rapid development of fluoroquinolone resistance in M. tuberculosis","volume":"349","author":"Ginsburg","year":"2003","journal-title":"N Engl J Med"},{"key":"R9-11-20241212","doi-asserted-by":"crossref","first-page":"e0117421","DOI":"10.1371\/journal.pone.0117421","article-title":"High rates of ofloxacin resistance in Mycobacterium tuberculosis among both new and previously treated patients in Tamil Nadu, South India","volume":"10","author":"Selvakumar","year":"2015","journal-title":"PLoS One"},{"key":"R10-11-20241212","doi-asserted-by":"crossref","first-page":"1069","DOI":"10.1086\/527442","article-title":"Fosfomycin: Use beyond urinary tract and gastrointestinal infections","volume":"46","author":"Falagas","year":"2008","journal-title":"Clin Infect Dis"},{"key":"R11-11-20241212","doi-asserted-by":"crossref","first-page":"798","DOI":"10.1111\/j.1751-1097.2010.00755.x","article-title":"Detection and prevention of ocular phototoxicity of ciprofloxacin and other fluoroquinolone antibiotics","volume":"86","author":"Zhao","year":"2010","journal-title":"Photochem Photobiol"},{"key":"R12-11-20241212","first-page":"1154","article-title":"Surveillance of drug-resistant tuberculosis in the state of Gujarat, India","volume":"13","author":"Ramachandran","year":"2009","journal-title":"Int J Tuberc Lung Dis"},{"key":"R13-11-20241212","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1016\/j.jgar.2017.08.014","article-title":"Baseline resistance and cross-resistance among fluoroquinolones in multidrug-resistant Mycobacterium tuberculosis isolates at a national reference laboratory in India","volume":"12","author":"Mamatha","year":"2018","journal-title":"J Glob Antimicrob Resist"},{"key":"R15-11-20241212","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1001\/archinte.162.1.41","article-title":"National patterns in the treatment of urinary tract infections in women by ambulatory care physicians","volume":"162","author":"Huang","year":"2002","journal-title":"Arch Intern Med"},{"key":"R16-11-20241212","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1086\/313954","article-title":"Practice guidelines for the management of community-acquired pneumonia in adults. Infectious Diseases Society of America","volume":"31","author":"Bartlett","year":"2000","journal-title":"Clin Infect Dis"},{"key":"R17-11-20241212","doi-asserted-by":"crossref","first-page":"341","DOI":"10.4103\/0971-5916.182625","article-title":"A study on pre-XDR & XDR tuberculosis & their prevalent genotypes in clinical isolates of Mycobacterium tuberculosis in North India","volume":"143","author":"Singhal","year":"2016","journal-title":"Indian J Med Res"}],"container-title":["Indian Journal of Medical Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.lww.com\/02223309-201949010-00011","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,7,2]],"date-time":"2025-07-02T23:01:06Z","timestamp":1751497266000},"score":1,"resource":{"primary":{"URL":"https:\/\/ijmr.org.in\/high-degree-of-fluoroquinolone-resistance-among-pulmonary-tuberculosis-patients-in-new-delhi-india\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,1]]},"references-count":12,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2019]]}},"URL":"https:\/\/doi.org\/10.4103\/ijmr.ijmr_1220_17","relation":{},"ISSN":["0971-5916"],"issn-type":[{"value":"0971-5916","type":"print"}],"subject":[],"published":{"date-parts":[[2019,1]]}}}