{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,6]],"date-time":"2025-11-06T12:35:25Z","timestamp":1762432525794,"version":"3.41.0"},"reference-count":28,"publisher":"Scientific Scholar","issue":"4","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2017,10]]},"abstract":"<jats:sec>\n            <jats:title>Background &amp; objectives:<\/jats:title>\n            <jats:p>Cystic fibrosis (CF) is a life-limiting genetic condition resulting in chronic respiratory infections, pancreatic enzyme insufficiency and associated complications. This pilot study was undertaken to assess the glucose tolerance and insulin secretion and sensitivity among Indian children with CF.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods:<\/jats:title>\n            <jats:p>Children with CF under regular follow up at the Paediatric Pulmonology Clinic of a tertiary care hospital in New Delhi, India, were enrolled. Children who had a history of acute exacerbation or intake of systemic steroids within the last two weeks were excluded. Anthropometry, pulmonary function and disease severity (Shwachman) score were assessed. Fasting venous sample was drawn to assess glucose, insulin, haemoglobin and calcium. Oral glucose tolerance test was performed, and blood glucose and insulin were assessed at 30, 60, 90 and 120 min. Insulin secretion and sensitivity indices were calculated.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results:<\/jats:title>\n            <jats:p>Twenty nine patients with a mean age of 11.2\u00b14.1 yr were enrolled. Stunting, thinness, anaemia and hypocalcaemia were present in 31.0, 13.8, 37.0 and 48.3 per cent of the patients, respectively. Abnormal glucose tolerance (AGT) was present in 21.4 per cent. Insulin secretion was similar in individuals with AGT and normal glucose tolerance (NGT), but insulin sensitivity index was lower (0.12\u00b10.02 <jats:italic toggle=\"yes\">vs<\/jats:italic> 0.15\u00b10.01, <jats:italic toggle=\"yes\">P<\/jats:italic>&lt;0.001) and homeostatic model assessment of insulin resistance higher [1.63 (0.53-1.76) <jats:italic toggle=\"yes\">vs<\/jats:italic> 0.83 (0.28-4.43), <jats:italic toggle=\"yes\">P<\/jats:italic>&lt;0.05] in individuals with AGT compared to NGT.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Interpretation &amp; conclusions:<\/jats:title>\n            <jats:p>AGT was observed in 21.4 per cent of children with CF. The CF patients with AGT had significantly lower insulin sensitivity compared to patients with NGT. Future multicentric studies with a large sample should be conducted to assess insulin secretion and sensitivity indices in CF patients compared to healthy controls.<\/jats:p>\n          <\/jats:sec>","DOI":"10.4103\/ijmr.ijmr_1360_15","type":"journal-article","created":{"date-parts":[[2024,12,19]],"date-time":"2024-12-19T19:24:58Z","timestamp":1734636298000},"page":"483-488","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":3,"title":["Glucose tolerance &amp; insulin secretion &amp; sensitivity characteristics in Indian children with cystic fibrosis"],"prefix":"10.25259","volume":"146","author":[{"given":"Vandana","family":"Jain","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Santosh","family":"Kumar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Naval K.","family":"Vikram","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mani","family":"Kalaivani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Surya Prakash","family":"Bhatt","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rajni","family":"Sharma","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sushil Kumar","family":"Kabra","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"10894","reference":[{"key":"R1-7-20241212","doi-asserted-by":"crossref","first-page":"1087","DOI":"10.1002\/ppul.20677","article-title":"Cystic fibrosis in India","volume":"42","author":"Kabra","year":"2007","journal-title":"Pediatr Pulmonol"},{"key":"R2-7-20241212","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1016\/j.jcf.2004.08.001","article-title":"Clinical importance of cystic fibrosis-related diabetes","volume":"3","author":"Brennan","year":"2004","journal-title":"J Cyst Fibros"},{"key":"R3-7-20241212","doi-asserted-by":"crossref","first-page":"540","DOI":"10.1016\/j.jpeds.2007.09.025","article-title":"Glucose tolerance and insulin secretion, morbidity, and death in patients with cystic fibrosis","volume":"152","author":"Bismuth","year":"2008","journal-title":"J Pediatr"},{"key":"R4-7-20241212","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1055\/s-0031-1275270","article-title":"Kinetics of insulin secretion and glucose intolerance in adult patients with cystic fibrosis","volume":"43","author":"Anzeneder","year":"2011","journal-title":"Horm Metab Res"},{"key":"R5-7-20241212","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1016\/j.jpeds.2007.05.012","article-title":"Glucose tolerance, insulin secretion, and insulin sensitivity in children and adolescents with cystic fibrosis and no prior history of diabetes","volume":"151","author":"Elder","year":"2007","journal-title":"J Pediatr"},{"key":"R6-7-20241212","doi-asserted-by":"crossref","first-page":"1187","DOI":"10.2337\/dc06-1915","article-title":"Glucose homeostasis and genotype-phenotype interplay in cystic fibrosis patients with CFTR gene deltaF508 mutation","volume":"30","author":"Preumont","year":"2007","journal-title":"Diabetes Care"},{"key":"R7-7-20241212","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1046\/j.1464-5491.2002.00666.x","article-title":"Cystic fibrosis-related diabetes: The role of peripheral insulin resistance and beta-cell dysfunction","volume":"19","author":"Yung","year":"2002","journal-title":"Diabet Med"},{"key":"R8-7-20241212","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1067\/mpd.2003.5","article-title":"Glucose intolerance in children with cystic fibrosis","volume":"142","author":"Solomon","year":"2003","journal-title":"J Pediatr"},{"key":"R9-7-20241212","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1016\/j.jcf.2007.06.004","article-title":"Characterisation of mutations and genotype-phenotype correlation in cystic fibrosis: Experience from India","volume":"7","author":"Shastri","year":"2008","journal-title":"J Cyst Fibros"},{"key":"R10-7-20241212","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1038\/ijo.2010.135","article-title":"Obesity-related non-communicable diseases: South Asians vs. White Caucasians","volume":"35","author":"Misra","year":"2011","journal-title":"Int J Obes (Lond"},{"key":"R11-7-20241212","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1001\/archpedi.1958.02060060008002","article-title":"Long-term study of one hundred five patients with cystic fibrosis; studies made over a five- to fourteen-year period","volume":"96","author":"Shwachman","year":"1958","journal-title":"AMA J Dis Child"},{"key":"R12-7-20241212","first-page":"1203","article-title":"Physical and sexual growth pattern of affluent Indian children from 5 to 18 years of age","volume":"29","author":"Agarwal","year":"1992","journal-title":"Indian Pediatr"},{"key":"R13-7-20241212","first-page":"1217","article-title":"Physical growth assessment in adolescence","volume":"38","author":"Agarwal","year":"2001","journal-title":"Indian Pediatr"},{"key":"R14-7-20241212","doi-asserted-by":"crossref","first-page":"660","DOI":"10.2471\/BLT.07.043497","article-title":"Development of a WHO growth reference for school-aged children and adolescents","volume":"85","author":"de Onis","year":"2007","journal-title":"Bull World Health Organ"},{"key":"R15-7-20241212","doi-asserted-by":"crossref","first-page":"e83","DOI":"10.2337\/dc10-0034","article-title":"Insulin assay standardization: Leading to measures of insulin sensitivity and secretion for practical clinical care: Response to Staten et al","volume":"33","author":"Heinemann","year":"2010","journal-title":"Diabetes Care"},{"key":"R17-7-20241212","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/j.jpeds.2003.09.045","article-title":"Validation of surrogate estimates of insulin sensitivity and insulin secretion in children and adolescents","volume":"144","author":"Gungor","year":"2004","journal-title":"J Pediatr"},{"key":"R18-7-20241212","doi-asserted-by":"crossref","first-page":"748","DOI":"10.1007\/s00125-005-1683-9","article-title":"Comparative evaluation of simple insulin sensitivity methods based on the oral glucose tolerance test","volume":"48","author":"Mari","year":"2005","journal-title":"Diabetologia"},{"key":"R19-7-20241212","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1016\/j.jcf.2009.08.007","article-title":"Validation of insulin secretion indices in cystic fibrosis patients","volume":"8","author":"Hammana","year":"2009","journal-title":"J Cyst Fibros"},{"key":"R20-7-20241212","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1530\/eje.1.01836","article-title":"Insulin-secretion abnormalities and clinical deterioration related to impaired glucose tolerance in cystic fibrosis","volume":"152","author":"Tof\u00e9","year":"2005","journal-title":"Eur J Endocrinol"},{"key":"R21-7-20241212","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1515\/JPEM.2001.14.1.53","article-title":"Early detection of impaired glucose tolerance in patients with cystic fibrosis and predisposition factors","volume":"14","author":"Garagorri","year":"2001","journal-title":"J Pediatr Endocrinol Metab"},{"key":"R22-7-20241212","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1016\/j.jcf.2007.02.005","article-title":"Increased glucose excursion in cystic fibrosis and its association with a worse clinical status","volume":"6","author":"Costa","year":"2007","journal-title":"J Cyst Fibros"},{"key":"R23-7-20241212","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1016\/j.anpedi.2012.05.015","article-title":"Abnormal glucose tolerance in prepubertal patients with cystic fibrosis","volume":"77","author":"Mart\u00edn-Fr\u00edas","year":"2012","journal-title":"An Pediatr (Barc"},{"key":"R24-7-20241212","doi-asserted-by":"crossref","first-page":"290","DOI":"10.4187\/respcare.00726","article-title":"Glucose intolerance in patients with cystic fibrosis: Sex-based differences in clinical score, pulmonary function, radiograph score, and 6-minute walk test","volume":"56","author":"Ziegler","year":"2011","journal-title":"Respir Care"},{"key":"R25-7-20241212","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1111\/ped.12214","article-title":"Prevalence of malnutrition and obesity among cystic fibrosis patients","volume":"56","author":"Panagopoulou","year":"2014","journal-title":"Pediatr Int"},{"key":"R26-7-20241212","doi-asserted-by":"crossref","first-page":"977","DOI":"10.4067\/S0034-98872011000800001","article-title":"Growth and pulmonary function in Chilean children and adolescents with cystic fibrosis","volume":"139","author":"Barja","year":"2011","journal-title":"Rev Med Chil"},{"key":"R27-7-20241212","doi-asserted-by":"crossref","first-page":"1029","DOI":"10.1111\/j.1651-2227.2003.tb02571.x","article-title":"Pubertal growth and development in cystic fibrosis: A retrospective review","volume":"92","author":"Aswani","year":"2003","journal-title":"Acta Paediatr"},{"key":"R28-7-20241212","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1002\/ppul.22857","article-title":"Iron deficiency occurs frequently in children with cystic fibrosis","volume":"49","author":"Uijterschout","year":"2014","journal-title":"Pediatr Pulmonol"},{"key":"R29-7-20241212","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1513\/AnnalsATS.201306-171BC","article-title":"Vitamin D status in children with cystic fibrosis.Associations with inflammation and bacterial colonization","volume":"11","author":"Simoneau","year":"2014","journal-title":"Ann Am Thorac Soc"}],"container-title":["Indian Journal of Medical Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.lww.com\/02223309-201746040-00007","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,7,2]],"date-time":"2025-07-02T22:59:27Z","timestamp":1751497167000},"score":1,"resource":{"primary":{"URL":"https:\/\/ijmr.org.in\/glucose-tolerance-insulin-secretion-sensitivity-characteristics-in-indian-children-with-cystic-fibrosis-a-pilot-study\/"}},"subtitle":["A pilot study"],"short-title":[],"issued":{"date-parts":[[2017,10]]},"references-count":28,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2017]]}},"URL":"https:\/\/doi.org\/10.4103\/ijmr.ijmr_1360_15","relation":{},"ISSN":["0971-5916"],"issn-type":[{"type":"print","value":"0971-5916"}],"subject":[],"published":{"date-parts":[[2017,10]]}}}