{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,28]],"date-time":"2026-01-28T14:07:50Z","timestamp":1769609270261,"version":"3.49.0"},"reference-count":22,"publisher":"Scientific Scholar","issue":"5","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2021,11]]},"abstract":"<jats:sec>\n            <jats:title>Background &amp; objectives:<\/jats:title>\n            <jats:p>Evaluation of bone marrow infiltration in lymphoma is usually done by bone marrow biopsy (BMB). This study analyzed the utility of <jats:sup>18<\/jats:sup>F-fluorodeoxyglucose positron emission tomography\/computerized tomography (<jats:sup>18<\/jats:sup>F-FDG PET\/CT) to detect bone marrow involvement (BMI) compared to BMB.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods:<\/jats:title>\n            <jats:p>Treatment-na\u00efve lymphoma patients underwent both <jats:sup>18<\/jats:sup>F-FDG PET\/CT scan and BMB before treatment initiation. BMI detected on PET\/CT was compared with BMB.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results:<\/jats:title>\n            <jats:p>The study population consisted of 80 patients and comprised 37 Hodgkin\u2019s lymphoma (HL) patients, 30 aggressive non-HL (NHL) and 13 indolent NHL patients. The majority of the aggressive NHLs were diffuse large B-cell lymphoma (20\/30) and major indolent lymphoma was follicular lymphoma (5\/13). When compared to BMB, sensitivity, specificity, positive predictive value (PPV) and negative predictive value (NPV) of focal (\u00b1diffuse) marrow FDG uptake on <jats:sup>18<\/jats:sup>F-FDG PET\/CT were 100, 61.3, 33.3 and 100 per cent, respectively, for HL; 100, 65.4, 30.8 and 100 per cent, respectively, for aggressive NHL and 75, 80, 85.7 and 66.7 per cent, respectively, for indolent NHL. When comparing marrow involvement on <jats:sup>18<\/jats:sup>F-FDG PET\/CT to baseline BMB and\/or resolution of bone marrow FDG uptake at interim\/end-of-treatment <jats:sup>18<\/jats:sup>F-FDG PET\/CT, the sensitivity, specificity, PPV and NPV were 100 per cent each for HL and aggressive NHL and 77.3, 100, 100 and 66.7 per cent, respectively, for indolent NHL.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Interpretation &amp; conclusions:<\/jats:title>\n            <jats:p>\n                                 <jats:sup>18<\/jats:sup>F-FDG PET\/CT has a good sensitivity and NPV for detecting BMI in HL and aggressive lymphoma. The low specificity and PPV improved if marrow uptake pattern on interim or end-of-treatment <jats:sup>18<\/jats:sup>F-FDG PET\/CT scan was analyzed. In patients with HL who are staged with<jats:sup>18<\/jats:sup>F-FDG PET\/CT at baseline and followed up with an interim\/end-of-treatment PET\/CT, baseline BMB may be avoided. For all other lymphoma subtypes, BMB may be essential if there is no marrow FDG uptake on PET\/CT scan performed at baseline.<\/jats:p>\n          <\/jats:sec>","DOI":"10.4103\/ijmr.ijmr_1420_19","type":"journal-article","created":{"date-parts":[[2022,6,6]],"date-time":"2022-06-06T09:00:17Z","timestamp":1654506017000},"page":"691-698","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":5,"title":["Utility of 18F-fluorodeoxyglucose PET-CT scan in detecting bone marrow involvement in lymphoma"],"prefix":"10.25259","volume":"154","author":[{"given":"Ankit Kumar","family":"Jitani","sequence":"first","affiliation":[{"name":"Department of Hematology, Nilratan Sircar Medical College, Kolkata, West Bengal, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shyamali","family":"Dutta","sequence":"additional","affiliation":[{"name":"Department of Hematology, Nilratan Sircar Medical College, Kolkata, West Bengal, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Prakas Kumar","family":"Mandal","sequence":"additional","affiliation":[{"name":"Department of Hematology, Nilratan Sircar Medical College, Kolkata, West Bengal, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rajib","family":"De","sequence":"additional","affiliation":[{"name":"Department of Hematology, Nilratan Sircar Medical College, Kolkata, West Bengal, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ekta","family":"Jajodia","sequence":"additional","affiliation":[{"name":"Department of Hematology, Christian Medical College & Hospital, Vellore, Tamil Nadu, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shuvraneel","family":"Baul","sequence":"additional","affiliation":[{"name":"Department of Hematology, Nilratan Sircar Medical College, Kolkata, West Bengal, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Prantar","family":"Chakrabarti","sequence":"additional","affiliation":[{"name":"Department of Hematology, Nilratan Sircar Medical College, Kolkata, West Bengal, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tuphan Kanti","family":"Dolai","sequence":"additional","affiliation":[{"name":"Department of Hematology, Nilratan Sircar Medical College, Kolkata, West Bengal, India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"10894","reference":[{"key":"B1-20241212","doi-asserted-by":"crossref","first-page":"1630","DOI":"10.1200\/JCO.1989.7.11.1630","article-title":"Report of a committee convened to discuss the evaluation and staging of patients with Hodgkin's disease:Cotswolds meeting","volume":"7","author":"Lister","year":"1989","journal-title":"J Clin Oncol"},{"key":"B2-20241212","doi-asserted-by":"crossref","first-page":"25","DOI":"10.2967\/jnumed.109.067892","article-title":"(18)F-FDG avidity in lymphoma readdressed:A study of 766 patients","volume":"51","author":"Weiler-Sagie","year":"2010","journal-title":"J Nucl Med"},{"key":"B3-20241212","doi-asserted-by":"crossref","first-page":"3059","DOI":"10.1200\/JCO.2013.54.8800","article-title":"Recommendations for initial evaluation, staging, and response assessment of Hodgkin and non-Hodgkin lymphoma:The Lugano classification","volume":"32","author":"Cheson","year":"2014","journal-title":"J Clin Oncol"},{"key":"B4-20241212","doi-asserted-by":"crossref","first-page":"iv19","DOI":"10.1093\/annonc\/mdy080","article-title":"Hodgkin lymphoma:ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up","volume":"29","author":"Eichenauer","year":"2018","journal-title":"Ann Oncol"},{"key":"B5-20241212","doi-asserted-by":"crossref","first-page":"1217","DOI":"10.1200\/JCO.2014.58.7360","article-title":"Do not abandon the bone marrow biopsy yet in diffuse large B-cell lymphoma","volume":"33","author":"Adams","year":"2015","journal-title":"J Clin Oncol"},{"key":"B6-20241212","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1002\/ajh.23986","article-title":"False-negative FDG-PET in histologically proven extensive large cell bone marrow involvement in diffuse large B-cell lymphoma","volume":"90","author":"Adams","year":"2015","journal-title":"Am J Hematol"},{"key":"B7-20241212","doi-asserted-by":"crossref","first-page":"686","DOI":"10.1002\/ajh.24044","article-title":"The role of bone marrow biopsy and FDG-PET\/CT in identifying bone marrow infiltration in the initial diagnosis of high grade non-Hodgkin B-cell lymphoma and Hodgkin lymphoma. 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