{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T19:16:27Z","timestamp":1792523787712,"version":"4.5.0"},"reference-count":31,"publisher":"Scientific Scholar","issue":"1","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2019,7]]},"abstract":"\n Background & objectives:<\/jats:title>\n Brain-derived neurotrophic factor (BDNF) facilitates neuronal survival, differentiation and synaptic connectivity and affects neurotransmission throughout the brain. However, it has also a modulatory role in energy homeostasis, obesity and cardiovascular function. Obesity, high body mass index (BMI) and dyslipidaemia, among other factors, contribute to coronary heart disease (CHD) development. The exact role of BDNF in development of CHD is not well defined. This study was aimed to evaluate if plasma BDNF concentration was associated with CHD in ethnically homogeneous groups of patients and to correlate plasma BDNF levels with known risk factors for CHD.<\/jats:p>\n <\/jats:sec>\n \n Methods:<\/jats:title>\n Plasma BDNF concentration, BDNF<\/jats:italic> Val66Met polymorphism and other biological and anthropological risk factors for CHD were determined in 208 patients with CHD and 156 healthy controls.<\/jats:p>\n <\/jats:sec>\n \n Results:<\/jats:title>\n Plasma BDNF<\/jats:italic> concentration was significantly (P<\/jats:italic><0.01) reduced in patients with CHD compared to controls, and it was not influenced by gender, age, smoking or BDNF<\/jats:italic> Val66Met polymorphism. It was considerably correlated with cholesterol (P<\/jats:italic>=0.004), low-density lipoprotein (P<\/jats:italic>=0.006), and diastolic blood pressure (P<\/jats:italic>=0.018) in patients with CHD and with platelet number (P<\/jats:italic>=0.003) in healthy controls.<\/jats:p>\n <\/jats:sec>\n \n Interpretation & conclusions:<\/jats:title>\n The results revealed lower plasma BDNF<\/jats:italic> concentration in patients with CHD, suggesting that decreased plasma BDNF<\/jats:italic> concentration might be associated with CHD pathogenesis. Longitudinal studies with a large sample need to be conducted to confirm these findings.<\/jats:p>\n <\/jats:sec>","DOI":"10.4103\/ijmr.ijmr_1566_17","type":"journal-article","created":{"date-parts":[[2019,9,30]],"date-time":"2019-09-30T20:22:38Z","timestamp":1569874958000},"page":"43-49","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":30,"title":["Association between reduced brain-derived neurotrophic factor concentration & coronary heart disease"],"prefix":"10.25259","volume":"150","author":[{"given":"Aleksandra","family":"Sustar","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matea Nikolac","family":"Perkovic","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gordana Nedic","family":"Erjavec","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dubravka Svob","family":"Strac","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nela","family":"Pivac","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"10894","reference":[{"key":"R1-6-20241212","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1016\/S0079-6123(03)46018-4","article-title":"Neurotrophin presence in human coronary atherosclerosis and metabolic syndrome: A role for NGF and BDNF in cardiovascular disease?","volume":"146","author":"Chaldakov","year":"2004","journal-title":"Prog Brain Res"},{"key":"R2-6-20241212","doi-asserted-by":"crossref","first-page":"1925","DOI":"10.1016\/j.jacc.2008.12.068","article-title":"Obesity and cardiovascular disease: Risk factor, paradox, and impact of weight loss","volume":"53","author":"Lavie","year":"2009","journal-title":"J Am Coll Cardiol"},{"key":"R3-6-20241212","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1038\/nri2921","article-title":"Adipokines in inflammation and metabolic disease","volume":"11","author":"Ouchi","year":"2011","journal-title":"Nat Rev Immunol"},{"key":"R4-6-20241212","doi-asserted-by":"crossref","first-page":"1301","DOI":"10.1161\/CIRCULATIONAHA.111.067264","article-title":"Body fat distribution and risk of cardiovascular disease: An update","volume":"126","author":"Despr\u00e9s","year":"2012","journal-title":"Circulation"},{"key":"R5-6-20241212","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1016\/j.jacc.2008.03.066","article-title":"Measures of obesity and cardiovascular risk among men and women","volume":"52","author":"Gelber","year":"2008","journal-title":"J Am Coll Cardiol"},{"key":"R6-6-20241212","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/j.tins.2012.12.009","article-title":"BDNF and the central control of feeding: Accidental bystander or essential player?","volume":"36","author":"Rios","year":"2013","journal-title":"Trends Neurosci"},{"key":"R7-6-20241212","doi-asserted-by":"crossref","first-page":"e10099","DOI":"10.1371\/journal.pone.0010099","article-title":"Circulating brain-derived neurotrophic factor and indices of metabolic and cardiovascular health: Data from the baltimore longitudinal study of aging","volume":"5","author":"Golden","year":"2010","journal-title":"PLoS One"},{"key":"R8-6-20241212","doi-asserted-by":"crossref","first-page":"84","DOI":"10.5498\/wjp.v6.i1.84","article-title":"Are the changes in the peripheral brain-derived neurotrophic factor levels due to platelet activation?","volume":"6","author":"Serra-Mill\u00e0s","year":"2016","journal-title":"World J Psychiatry"},{"key":"R9-6-20241212","doi-asserted-by":"crossref","first-page":"1902","DOI":"10.1161\/ATVBAHA.112.248930","article-title":"Brain-derived neurotrophic factor protects against cardiac dysfunction after myocardial infarction via a central nervous system-mediated pathway","volume":"32","author":"Okada","year":"2012","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"R10-6-20241212","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/j.bbrc.2011.10.020","article-title":"Association of plasma brain-derived neurotrophic factor and cardiovascular risk factors and prognosis in angina pectoris","volume":"415","author":"Jiang","year":"2011","journal-title":"Biochem Biophys Res Commun"},{"key":"R11-6-20241212","doi-asserted-by":"crossref","first-page":"2114","DOI":"10.1161\/CIRCULATIONAHA.104.476903","article-title":"Possible role of brain-derived neurotrophic factor in the pathogenesis of coronary artery disease","volume":"112","author":"Ejiri","year":"2005","journal-title":"Circulation"},{"key":"R12-6-20241212","doi-asserted-by":"crossref","first-page":"130","DOI":"10.3389\/fimmu.2014.00130","article-title":"Triactome: Neuro-immune-adipose interactions. 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