{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T20:11:21Z","timestamp":1792613481883,"version":"4.5.0"},"reference-count":25,"publisher":"Scientific Scholar","issue":"2","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2024,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n          <jats:sec>\n            <jats:title>Background &amp; objectives:<\/jats:title>\n            <jats:p>Alcohol is one of most common aetiologies of cirrhosis and decompensated cirrhosis is linked to higher morbidity and death rates. This study looked at the outcomes and mortality associated risk variables of individuals with alcoholic cirrhosis who had hospitalization with their first episode of decompensation.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods:<\/jats:title>\n            <jats:p>Individuals with alcoholic cirrhosis who were hospitalized with the first episode of decompensation [acute decompensation (AD) or acute-on-chronic liver failure (ACLF)] were included in the study and were prospectively followed up until death or 90 days, whichever was earlier.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results:<\/jats:title>\n            <jats:p>Of the 227 study participants analyzed, 167 (73.56%) and 60 (26.43%) participants presented as AD and ACLF, respectively. In the ACLF group, the mortality rate at 90 days was higher than in the AD group (48.3 <jats:italic toggle=\"yes\">vs<\/jats:italic> 32.3%, <jats:italic toggle=\"yes\">P<\/jats:italic>=0.02). In the AD group, participants who initially presented with ascites as opposed to variceal haemorrhage had a greater mortality rate at 90 days (36.4 <jats:italic toggle=\"yes\">vs<\/jats:italic> 17.1%, <jats:italic toggle=\"yes\">P<\/jats:italic>=0.041). The chronic liver failure-consortium AD score and the lactate-free Asian Pacific Association for the study of the Liver-ACLF research consortium score best-predicted mortality in individuals with AD and ACLF.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Interpretation &amp; Conclusions:<\/jats:title>\n            <jats:p>There is significant heterogeneity in the type of decompensation in individuals with alcoholic cirrhosis. We observed significantly high mortality rate among alcoholic participants hospitalized with initial decompensation; deaths occurring in more than one-third of study participants within 90 days.<\/jats:p>\n          <\/jats:sec>","DOI":"10.4103\/ijmr.ijmr_1690_22","type":"journal-article","created":{"date-parts":[[2024,4,9]],"date-time":"2024-04-09T09:32:19Z","timestamp":1712655139000},"page":"213-222","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":2,"title":["Outcome of individuals with alcoholic cirrhosis hospitalized with first decompensation and their predictors"],"prefix":"10.25259","volume":"159","author":[{"given":"Suprabhat","family":"Giri","sequence":"first","affiliation":[{"name":"Department of Gastroenterology, Seth GS Medical College & KEM Hospital, Mumbai, Maharashtra, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sushrut","family":"Ingawale","sequence":"additional","affiliation":[{"name":"Department of General Medicine, Seth GS Medical College & KEM Hospital, Mumbai, Maharashtra, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sidharth","family":"Harindanath","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Seth GS Medical College & KEM Hospital, Mumbai, Maharashtra, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohit","family":"Jain","sequence":"additional","affiliation":[{"name":"Department of General Medicine, Seth GS Medical College & KEM Hospital, Mumbai, Maharashtra, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pranav","family":"Garg","sequence":"additional","affiliation":[{"name":"Department of General Medicine, Seth GS Medical College & KEM Hospital, Mumbai, Maharashtra, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harish","family":"Darak","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Seth GS Medical College & KEM Hospital, Mumbai, Maharashtra, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sanjay","family":"Kumar","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Seth GS Medical College & KEM Hospital, Mumbai, Maharashtra, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aditya","family":"Kale","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Seth GS Medical College & KEM Hospital, Mumbai, Maharashtra, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akash","family":"Shukla","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Seth GS Medical College & KEM Hospital, Mumbai, Maharashtra, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"10894","published-online":{"date-parts":[[2024,4,4]]},"reference":[{"key":"R1-20241212","doi-asserted-by":"crossref","first-page":"1749","DOI":"10.1016\/S0140-6736(14)60121-5","article-title":"Liver cirrhosis","volume":"383","author":"Tsochatzis","year":"2014","journal-title":"Lancet"},{"key":"R2-20241212","doi-asserted-by":"crossref","first-page":"959","DOI":"10.1016\/j.jhep.2021.12.022","article-title":"Baveno VII \u2013Renewing consensus in portal hypertension","volume":"76","author":"de Franchis","year":"2022","journal-title":"J Hepatol"},{"key":"R3-20241212","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1007\/s12072-019-09946-3","article-title":"Acute-on-chronic liver failure:Consensus recommendations of the Asian Pacific association for the study of the liver (APASL):An update","volume":"13","author":"Sarin","year":"2019","journal-title":"Hepatol Int"},{"key":"R4-20241212","doi-asserted-by":"crossref","first-page":"1426","DOI":"10.1053\/j.gastro.2013.02.042","article-title":"CANONIC study investigators of the EASL-CLIF consortium. 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