{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T04:05:14Z","timestamp":1754021114597,"version":"3.41.0"},"reference-count":74,"publisher":"Scientific Scholar","issue":"4","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2023,4]]},"abstract":"\n Background & objectives:<\/jats:title>\n During the COVID-19 pandemic, the death rate was reportedly 5-8 fold lower in India which is densely populated as compared to less populated western countries. The aim of this study was to investigate whether dietary habits were associated with the variations in COVID-19 severity and deaths between western and Indian population at the nutrigenomics level.<\/jats:p>\n <\/jats:sec>\n \n Methods:<\/jats:title>\n In this study nutrigenomics approach was applied. Blood transcriptome of severe COVID-19 patients from three western countries (showing high fatality) and two datasets from Indian patients were used. Gene set enrichment analyses were performed for pathways, metabolites, nutrients, etc<\/jats:italic>., and compared for western and Indian samples to identify the food- and nutrient-related factors, which may be associated with COVID-19 severity. Data on the daily consumption of twelve key food components across four countries were collected and a correlation between nutrigenomics analyses and per capita daily dietary intake was investigated.<\/jats:p>\n <\/jats:sec>\n \n Results:<\/jats:title>\n Distinct dietary habits of Indians were observed, which may be associated with low death rate from COVID-19. Increased consumption of red meat, dairy products and processed foods by western populations may increase the severity and death rate by activating cytokine storm-related pathways, intussusceptive angiogenesis, hypercapnia and enhancing blood glucose levels due to high contents of sphingolipids, palmitic acid and byproducts such as CO2<\/jats:sub> and lipopolysaccharide (LPS). Palmitic acid also induces ACE2 expression and increases the infection rate. Coffee and alcohol that are highly consumed in western countries may increase the severity and death rates from COVID-19 by deregulating blood iron, zinc and triglyceride levels. The components of Indian diets maintain high iron and zinc concentrations in blood and rich fibre in their foods may prevent CO2<\/jats:sub> and LPS-mediated COVID-19 severity. Regular consumption of tea by Indians maintains high high-density lipoprotein (HDL) and low triglyceride in blood as catechins in tea act as natural atorvastatin. Importantly, regular consumption of turmeric in daily food by Indians maintains strong immunity and curcumin in turmeric may prevent pathways and mechanisms associated with SARS-CoV-2 infection and COVID-19 severity and lowered the death rate.<\/jats:p>\n <\/jats:sec>\n \n Interpretation & conclusions:<\/jats:title>\n Our results suggest that Indian food components suppress cytokine storm and various other severity related pathways of COVID-19 and may have a role in lowering severity and death rates from COVID-19 in India as compared to western populations. However, large multi-centered case\u2212control studies are required to support our current findings.<\/jats:p>\n <\/jats:sec>","DOI":"10.4103\/ijmr.ijmr_1701_22","type":"journal-article","created":{"date-parts":[[2023,4,28]],"date-time":"2023-04-28T05:56:14Z","timestamp":1682661374000},"page":"293-303","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":1,"title":["Indian food habit & food ingredients may have a role in lowering the severity & high death rate from COVID-19 in Indians: findings from the first nutrigenomic analysis"],"prefix":"10.25259","volume":"157","author":[{"given":"Debmalya","family":"Barh","sequence":"first","affiliation":[{"name":"Centre for Genomics and Applied Gene Technology, Institute of Integrative Omics & Applied Biotechnology, Purba Medinipur, West Bengal, India"},{"name":"Department of Genetics, Ecology & Evolution, Institute of Biological Sciences, Belo Horizonte, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fl\u00e1via Figueira","family":"Aburjaile","sequence":"additional","affiliation":[{"name":"Department of Preventative Veterinary Medicine, School of Veterinary Medicine, Belo Horizonte, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thais Silva","family":"Tavares","sequence":"additional","affiliation":[{"name":"Department of Laboratory of Algorithms in Biology, Institute of Biological Sciences, Belo Horizonte, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Miguel Etcheverria da","family":"Silva","sequence":"additional","affiliation":[{"name":"Department of Genetics, Ecology & Evolution, Institute of Biological Sciences, Belo Horizonte, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gabriel Pissolati Mattos","family":"Bretz","sequence":"additional","affiliation":[{"name":"Department of Applied Sciences to Adult Health Care Program, Belo Horizonte, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Igor Fernando Martins","family":"Rocha","sequence":"additional","affiliation":[{"name":"Department of Centre of Research on Health Vulnerability, Faculty of Medicine, Federal University of Minas Gerais, Belo Horizonte, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Annesha","family":"Dey","sequence":"additional","affiliation":[{"name":"Centre for Genomics and Applied Gene Technology, Institute of Integrative Omics & Applied Biotechnology, Purba Medinipur, West Bengal, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Renan Pedra de","family":"Souza","sequence":"additional","affiliation":[{"name":"Department of Laboratory of Integrative Biology, Institute of Biological Sciences, Belo Horizonte, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arist\u00f3teles","family":"G\u00f3es-Neto","sequence":"additional","affiliation":[{"name":"Department of Genetics, Ecology & Evolution, Institute of Biological Sciences, Belo Horizonte, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S\u00e9rvio Pontes","family":"Ribeiro","sequence":"additional","affiliation":[{"name":"Department of Laboratory of Ecology of Diseases & Forests, Nucleus of Biological Research, Universidade Federal de Ouro Preto, Ouro Preto, MG, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Khalid J.","family":"Alzahrani","sequence":"additional","affiliation":[{"name":"Department of Clinical Laboratories Sciences, College of Applied Medical Sciences, Taif University, Taif, Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ahmad A.","family":"Alghamdi","sequence":"additional","affiliation":[{"name":"Department of Clinical Laboratories Sciences, College of Applied Medical Sciences, Taif University, Taif, Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fuad M.","family":"Alzahrani","sequence":"additional","affiliation":[{"name":"Department of Clinical Laboratories Sciences, College of Applied Medical Sciences, Taif University, Taif, Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ibrahim Faisal","family":"Halawani","sequence":"additional","affiliation":[{"name":"Department of Clinical Laboratories Sciences, College of Applied Medical Sciences, Taif University, Taif, Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sandeep","family":"Tiwari","sequence":"additional","affiliation":[{"name":"Department of Post-Graduation Programs in Microbiology and Immunology, Institute of Biology and Health Sciences, Federal University of Bahia, Salvador, BA, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alaa A. 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