{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,18]],"date-time":"2026-03-18T11:31:06Z","timestamp":1773833466635,"version":"3.50.1"},"reference-count":15,"publisher":"Scientific Scholar","issue":"3&4","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2022,3]]},"abstract":"\n Background & objectives:<\/jats:title>\n Cardiovascular disease (CVD) remains the leading cause of mortality among patients with chronic kidney disease (CKD). Liver function tests (LFTs) have emerged as markers of CVD risk in some population-based studies. Hence, in the present study the relation between LFTs and biochemical cardiovascular risk factors (CRFs) were evaluated in CKD patients.<\/jats:p>\n <\/jats:sec>\n \n Methods:<\/jats:title>\n A total of 246 patients with stage 3-5 pre-dialysis CKD were enrolled. Demographics, LFTs [alanine aminotransferase (ALT), aspartate aminotransferase (AST) and gamma-glutamyltransferase (GGT)] and biochemical CRFs were recorded retrospectively. Glomerular filtration rate (GFR) was calculated using CKD-EPI equation.<\/jats:p>\n <\/jats:sec>\n \n Results:<\/jats:title>\n ALT was positively correlated with GFR, albumin, triglyceride and 25-hydroxyvitamin D and negatively correlated with CRP and intact parathyroid hormone (iPTH); AST was positively correlated with GFR, albumin, high-density lipoprotein cholesterol (HDL-C) and 25-hydroxyvitamin D and negatively correlated with CRP and iPTH; GGT was positively correlated with GFR, CRP and triglyceride and negatively correlated with HDL-C. In diabetic patients, ALT correlated positively with GFR; AST correlated positively with GFR and HDL-C, but correlated negatively with iPTH. In the correlation analysis between GFR and CRF, GFR was positively correlated with albumin, triglyceride and 25-hydroxyvitamin D and negatively correlated with CRP, iPTH and albuminuria in both total study population and diabetic group. A partial correlation analysis revealed no correlation between LFTs and CRFs after being controlled for GFR.<\/jats:p>\n <\/jats:sec>\n \n Interpretation & conclusions:<\/jats:title>\n The results of the present study suggest that the relationship between LFTs and biochemical CRFs seems to be a function of impaired GFR.<\/jats:p>\n <\/jats:sec>","DOI":"10.4103\/ijmr.ijmr_1777_19","type":"journal-article","created":{"date-parts":[[2022,8,17]],"date-time":"2022-08-17T04:30:18Z","timestamp":1660710618000},"page":"397-402","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":8,"title":["Relationship between liver function tests & cardiovascular risk factors in stage 3-5 pre-dialysis chronic kidney disease"],"prefix":"10.25259","volume":"155","author":[{"given":"Tamer","family":"Selen","sequence":"first","affiliation":[{"name":"Department of Nephrology, Health Sciences University Ankara D\u0131\u015fkap\u0131 Y\u0131ld\u0131r\u0131m Beyaz\u0131t Education & Research Hospital, Ankara, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hadim","family":"Akoglu","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Health Sciences University Ankara G\u00fclhane Education & Research Hospital, Ankara, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kemal","family":"Agbaht","sequence":"additional","affiliation":[{"name":"Department of Endocrinology & Metabolic Diseases, Private Defne Hospital, Hatay, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"10894","reference":[{"key":"B1-20241212","doi-asserted-by":"crossref","first-page":"1296","DOI":"10.1056\/NEJMoa041031","article-title":"Chronic kidney disease and the risks of death, cardiovascular events, and hospitalization","volume":"351","author":"Go","year":"2004","journal-title":"N Engl J 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