{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,19]],"date-time":"2025-12-19T09:40:54Z","timestamp":1766137254341,"version":"3.41.0"},"reference-count":17,"publisher":"Scientific Scholar","issue":"6","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2019,6]]},"abstract":"<jats:sec>\n            <jats:title>Background &amp; objectives:<\/jats:title>\n            <jats:p>High-altitude pulmonary oedema (HAPE) continues to challenge the healthcare providers at remote, resource-constrained settings. High-altitude terrain itself precludes convenience of resources. This study was conducted to evaluate the rise in peripheral capillary saturation of oxygen (SpO<jats:sub>2<\/jats:sub>) by the use of a partial rebreathing mask (PRM) in comparison to Hudson's mask among patients with HAPE.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods:<\/jats:title>\n            <jats:p>This was a single-centre, randomized crossover study to determine the efficiency of PRM in comparison to Hudson's mask. A total of 88 patients with HAPE referred to a secondary healthcare facility at an altitude of 11,500 feet from January to October 2013 were studied. A crossover after adequate wash-out on both modalities was conducted for first two days of hospital admission. All patients with HAPE were managed with bed rest and stand-alone oxygen supplementation with no adjuvant pharmacotherapy.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results:<\/jats:title>\n            <jats:p>The mean SpO<jats:sub>2<\/jats:sub> on ambient air on arrival was 66.92\u00b110.8 per cent for all patients with HAPE. Higher SpO<jats:sub>2<\/jats:sub> values were achieved with PRM in comparison to Hudson's mask on day one (86.08\u00b15.15 vs. 77.23\u00b19.09%) and day two (89.94\u00b12.96 vs. 83.39\u00b15.93%). The difference was more pronounced on day one as compared to day two.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Interpretation &amp; conclusions:<\/jats:title>\n            <jats:p>Mean SpO<jats:sub>2<\/jats:sub> values were found to be significantly higher among HAPE patients using PRM compared to those on Hudson's mask. Further studies to understand the translation of this incremental response in SpO<jats:sub>2<\/jats:sub> to clinical benefits (recovery times, mortality rates and hospital stay) need to be undertaken.<\/jats:p>\n          <\/jats:sec>","DOI":"10.4103\/ijmr.ijmr_1981_17","type":"journal-article","created":{"date-parts":[[2019,9,3]],"date-time":"2019-09-03T10:17:29Z","timestamp":1567505849000},"page":"778-782","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":5,"title":["High-altitude pulmonary oedema"],"prefix":"10.25259","volume":"149","author":[{"given":"Uday","family":"Yanamandra","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manisha","family":"Sharma","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Deeksha","family":"Katoch","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sushma","family":"Yanamandra","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Srinivasa A.","family":"Bhattachar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amul","family":"Gupta","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sagarika","family":"Patyal","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rajan","family":"Grewal","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Suman","family":"Kumar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Velu","family":"Nair","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"10894","reference":[{"key":"R1-12-20241212","doi-asserted-by":"crossref","first-page":"1229","DOI":"10.1164\/rccm.201207-1323CI","article-title":"High-altitude medicine","volume":"186","author":"West","year":"2012","journal-title":"Am J Respir Crit Care Med"},{"key":"R2-12-20241212","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1580\/07-WEME-REV-173.1","article-title":"Update on high-altitude pulmonary edema: Pathogenesis, prevention, and treatment","volume":"19","author":"Stream","year":"2008","journal-title":"Wilderness Environ Med"},{"key":"R3-12-20241212","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1136\/thx.22.3.221","article-title":"An evaluation of oxygen therapy equipment. 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