{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T15:04:28Z","timestamp":1787238268175,"version":"build-2736575974"},"reference-count":24,"publisher":"Scientific Scholar","issue":"2","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2019,2]]},"abstract":"\n Background & objectives:<\/jats:title>\n \n Acinetobacter baumannii<\/jats:italic>\n is an opportunistic pathogen responsible for causing nosocomial infections.\n A. baumannii<\/jats:italic>\n develops resistance to various antimicrobial agents including carbapenems, thereby complicating the treatment. This study was performed to characterize the isolates for the presence of various \u03b2-lactamases encoding genes and to type the isolates to compare our clones with the existing international clones across five centres in India.\n <\/jats:p>\n <\/jats:sec>\n \n Methods:<\/jats:title>\n \n A total 75 non-repetitive clinical isolates of\n A. baumannii<\/jats:italic>\n from five different centres were included in this study. All the isolates were confirmed as\n A. baumannii<\/jats:italic>\n by\n bla<\/jats:italic>\n OXA-51-like<\/jats:sub>\n PCR. Multiplex PCR was performed to identify the presence of extended spectrum \u03b2-lactamases (ESBL) and carbapenemases. Multilocus sequence typing was performed to find the sequence type (ST) of the isolates. e-BURST analysis was done to assign each ST into respective clonal complex.\n <\/jats:p>\n <\/jats:sec>\n \n Results:<\/jats:title>\n \n bla<\/jats:italic>\n OXA-51-like<\/jats:sub>\n was present in all the 75 isolates. The predominant Class D carbapenemase was\n bla<\/jats:italic>\n OXA-23-like<\/jats:sub>\n followed by Class B carbapenemase,\n bla<\/jats:italic>\n NDM-like<\/jats:sub>\n . Class A carbapenemase was not observed.\n bla<\/jats:italic>\n PER-like<\/jats:sub>\n was the predominant extended spectrum \u03b2-lactamase. ST-848, ST-451 and ST-195 were the most common STs. Eight-novel STs were identified. e-BURST analysis showed that the 75\n A. baumannii<\/jats:italic>\n isolates were clustered into seven clonal complexes and four singletons, of which, clonal complex 208 was the largest.\n <\/jats:p>\n <\/jats:sec>\n \n Interpretation & conclusions:<\/jats:title>\n \n Most of the isolates were grouped under clonal complex 208 which belongs to the international clonal lineage 2. High occurrence of ST-848 carrying\n bla<\/jats:italic>\n OXA-23-like<\/jats:sub>\n gene suggested that ST-848 could be an emerging lineage spreading carbapenem resistance in India.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.4103\/ijmr.ijmr_2085_17","type":"journal-article","created":{"date-parts":[[2019,6,3]],"date-time":"2019-06-03T03:30:52Z","timestamp":1559532652000},"page":"240-246","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":49,"title":["Molecular characterization & epidemiology of carbapenem-resistant Acinetobacter baumannii collected across India"],"prefix":"10.25259","volume":"149","author":[{"given":"Saranya","family":"Vijayakumar","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Purva","family":"Mathur","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arti","family":"Kapil","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bimal K.","family":"Das","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pallab","family":"Ray","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vikas","family":"Gautam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sujatha","family":"Sistla","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Subhash 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