{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T14:38:59Z","timestamp":1785249539027,"version":"3.55.0"},"reference-count":30,"publisher":"Scientific Scholar","issue":"4","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2023,10]]},"abstract":"<jats:sec>\n            <jats:title>Background &amp; objectives:<\/jats:title>\n            <jats:p>In view of anecdotal reports of sudden unexplained deaths in India\u2019s apparently healthy young adults, linking to coronavirus disease 2019 (COVID-19) infection or vaccination, we determined the factors associated with such deaths in individuals aged 18-45 years through a multicentric matched case\u2013control study.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods:<\/jats:title>\n            <jats:p>This study was conducted through participation of 47 tertiary care hospitals across India. Cases were apparently healthy individuals aged 18-45 years without any known co-morbidity, who suddenly (&lt;24 h of hospitalization or seen apparently healthy 24 h before death) died of unexplained causes during 1<jats:sup>st<\/jats:sup> October 2021-31<jats:sup>st<\/jats:sup> March 2023. Four controls were included per case matched for age, gender and neighborhood. We interviewed\/perused records to collect data on COVID-19 vaccination\/infection and post-COVID-19 conditions, family history of sudden death, smoking, recreational drug use, alcohol frequency and binge drinking and vigorous-intensity physical activity two days before death\/interviews. We developed regression models considering COVID-19 vaccination \u226442 days before outcome, any vaccine received anytime and vaccine doses to compute an adjusted matched odds ratio (aOR) with 95 per cent confidence interval (CI).<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results:<\/jats:title>\n            <jats:p>Seven hundred twenty nine cases and 2916 controls were included in the analysis. Receipt of at least one dose of COVID-19 vaccine lowered the odds [aOR (95% CI)] for unexplained sudden death [0.58 (0.37, 0.92)], whereas past COVID-19 hospitalization [3.8 (1.36, 10.61)], family history of sudden death [2.53 (1.52, 4.21)], binge drinking 48 h before death\/interview [5.29 (2.57, 10.89)], use of recreational drug\/substance [2.92 (1.1, 7.71)] and performing vigorous-intensity physical activity 48 h before death\/interview [3.7 (1.36, 10.05)] were positively associated. Two doses lowered the odds of unexplained sudden death [0.51 (0.28, 0.91)], whereas single dose did not.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Interpretation &amp; conclusions:<\/jats:title>\n            <jats:p>COVID-19 vaccination did not increase the risk of unexplained sudden death among young adults in India. Past COVID-19 hospitalization, family history of sudden death and certain lifestyle behaviors increased the likelihood of unexplained sudden death.<\/jats:p>\n          <\/jats:sec>","DOI":"10.4103\/ijmr.ijmr_2105_23","type":"journal-article","created":{"date-parts":[[2023,11,20]],"date-time":"2023-11-20T10:57:19Z","timestamp":1700477839000},"page":"351-362","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":17,"title":["Factors associated with unexplained sudden deaths among adults aged 18-45 years in India \u2013 A multicentric matched case\u2013control study"],"prefix":"10.25259","volume":"158","author":[{"given":"Manickam","family":"Ponnaiah","sequence":"first","affiliation":[{"name":"Division of Online Courses, Chennai, Tamil Nadu, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tarun","family":"Bhatnagar","sequence":"additional","affiliation":[{"name":"ICMR School of Public Health, Chennai, Tamil 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