{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,10]],"date-time":"2026-06-10T16:28:33Z","timestamp":1781108913154,"version":"3.54.1"},"reference-count":25,"publisher":"Scientific Scholar","issue":"6","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2022,12]]},"abstract":"\n Background & objectives:<\/jats:title>\n Human papillomavirus (HPV) infection is known to be the main cause of cervical cancer. This study aimed to determine the prevalence of high-risk HPV genotypes in smear specimens taken from women who had normal or abnormal cytology using a multiplex PCR method.<\/jats:p>\n <\/jats:sec>\n \n Methods:<\/jats:title>\n The study included 270 women aged between 19 and 69 yr with or without suspicious cervical abnormalities. A Pap smear sample from each patient was cytologically examined, and HPV typing was performed using a multiplex fluorescent PCR method. Those who were high-risk HPV positive and had a normal or abnormal cytology were further evaluated by colposcopy and biopsy.<\/jats:p>\n <\/jats:sec>\n \n Results:<\/jats:title>\n The total HPV positivity was 43 per cent (116\/270). HPV positivity in the patients with an abnormal cytology was 77 per cent (33\/43), whereas it was only 37 per cent (83\/227) in women with normal cytology, which showed a significant difference (P<\/jats:italic><0.05). HPV positivity was also related to the age group when all the subjects were considered (P<\/jats:italic><0.05), and the highest prevalence of HPV infection was in the 30-39 yr age group. High-risk HPV types 16, 18, 31, 35, 51 and 56 were more common in the normal cytology patients, whereas high-risk HPV types 16, 31, 35, 45, 58 and 68 were commonly found in the abnormal cytology patients.<\/jats:p>\n <\/jats:sec>\n \n Interpretation & conclusions:<\/jats:title>\n The determination of high-risk HPV genotypes in women with clinically suspicious cervical lesions should be conducted during an annual follow-up, irrespective of a normal or abnormal cytology by the age of 30 years or above.<\/jats:p>\n <\/jats:sec>","DOI":"10.4103\/ijmr.ijmr_2335_20","type":"journal-article","created":{"date-parts":[[2023,4,2]],"date-time":"2023-04-02T10:04:47Z","timestamp":1680429887000},"page":"786-791","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":3,"title":["High-risk human papillomavirus in Turkish patients with clinically suspicious cervical lesions analyzed by 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