{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,21]],"date-time":"2026-06-21T07:56:47Z","timestamp":1782028607727,"version":"3.54.5"},"reference-count":16,"publisher":"Scientific Scholar","issue":"6","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2022,12]]},"abstract":"\n Background & objectives:<\/jats:title>\n As per national guidelines, prospective blood donors with a history of jaundice of unknown cause are deferred permanently to prevent the transmission of hepatitis B and C. The validity of this guideline was tested by comparing prevalence rates of hepatitis B and C in prospective blood donors deferred due to a history of jaundice, with that of donors who were found fit.<\/jats:p>\n <\/jats:sec>\n \n Methods:<\/jats:title>\n Blood samples of 212 consecutive donors (male, n=203) deferred due to a history of jaundice were studied for hepatitis B and C by rapid test kits as well as by chemiluminescence (n=115) or ELISA (n=97). Consecutive healthy donors (n=549; male, n=518) were also studied by ELISA (n=266) or chemiluminescence (n=283).<\/jats:p>\n <\/jats:sec>\n \n Results:<\/jats:title>\n The cumulative prevalence detected by rapid test kit and ELISA\/chemiluminescence tests of hepatitis B (n=10) and C (n=2) among donors deferred due to a history of jaundice (n=212) was 5.7 per cent [95% confidence interval (CI): 2.9, 9.9]. The prevalence of reactive results among healthy donors (n=549) by ELISA\/chemiluminescence tests was 3.3 per cent (95% CI: 1.9, 5.2), which included hepatitis B (n=15) and hepatitis C (n=3) cases. Compared to healthy donors, the odds of seropositivity among jaundice-deferred donors was 1.7 (95% CI: 0.8, 3.6), P<\/jats:italic>=0.15. For rapid test-negative deferred donors, the odds of seropositivity by ELISA\/chemiluminescence declined to 0.4 (0.1, 1.5), P<\/jats:italic>=0.19.<\/jats:p>\n <\/jats:sec>\n \n Interpretation & conclusions:<\/jats:title>\n The prevalence rates of hepatitis B and C in prospective blood donors deferred due to a history of jaundice of unknown aetiology did not differ significantly from that in healthy donors. The current practice of permanently deferring such donors depletes valuable donor pool. A strategy of rejecting only those donors who are found reactive on pre-donation testing by rapid test needs further validation.<\/jats:p>\n <\/jats:sec>","DOI":"10.4103\/ijmr.ijmr_2504_19","type":"journal-article","created":{"date-parts":[[2023,4,10]],"date-time":"2023-04-10T06:35:28Z","timestamp":1681108528000},"page":"750-755","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":1,"title":["Prevalence of hepatitis B & C infections in prospective blood donors deferred due to history of jaundice"],"prefix":"10.25259","volume":"156","author":[{"given":"Mohd. Fawad Farooq","family":"Khan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kamran","family":"Afzal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S. H.","family":"Arif","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shadma","family":"Shahin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"10894","reference":[{"key":"R4-7-20241212","doi-asserted-by":"crossref","first-page":"e00352","DOI":"10.1128\/JCM.00352-18","article-title":"Transfusion-transmitted infections: An update on product screening, diagnostic techniques, and the path ahead","volume":"56","author":"Dean","year":"2018","journal-title":"J Clin Microbiol"},{"key":"R5-7-20241212","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1111\/j.1423-0410.2010.01426.x","article-title":"Hepatitis B, hepatitis C and HIV transfusion-transmitted infections in the 21st century","volume":"100","author":"Dwyre","year":"2011","journal-title":"Vox 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