{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T19:52:00Z","timestamp":1787169120650,"version":"build-2736575974"},"reference-count":14,"publisher":"Scientific Scholar","issue":"3","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2020,9]]},"abstract":"\n Background & objectives:<\/jats:title>\n Blood transfusion therapy involves multiple steps to ensure selection of safe blood component for transfusion. This includes testing for infectious markers, full ABO compatibility, free from any clinically significant red cell antibodies and acceptable donor's red cell survival rates without destruction of recipient's red cells. The red cell antibodies present in healthy blood donors can cause severe haemolytic transfusion reaction, especially in massive blood transfusion recipients and paediatric patients. Hence, screening of red cell antibodies in donor blood is important to provide compatible blood products and to avoid haemolytic transfusion reactions in susceptible patient population. This study was planned to assess prevalence, aetiology and type of unexpected red cell antibodies in a large number of whole blood donor population in north India.<\/jats:p>\n <\/jats:sec>\n \n Methods:<\/jats:title>\n This three-year prospective observational study included blood donor samples for antibody screening from January 2015 to December 2017. A total of 166,803 healthy blood donors including 156,128 (93.6%) males and 10,675 (6.4%) females were screened.<\/jats:p>\n <\/jats:sec>\n \n Results:<\/jats:title>\n The prevalence of red cell antibodies was 0.17 per cent in our donor population. Of the total 286 donors with red cell antibodies, 248 (86.7%) had alloantibodies, 30 (10.5%) had autoantibodies and eight donors (2.8%) showed positive antibody screening with inconclusive results.<\/jats:p>\n <\/jats:sec>\n \n Interpretation & conclusions:<\/jats:title>\n Alloimmunization to red cell antigens is a challenging task for current transfusion practices. The antibody screening in blood donors may improve the quality and safety of blood transfusion in the recipients. It also reduces the risk of complications from incompatible blood transfusions.<\/jats:p>\n <\/jats:sec>","DOI":"10.4103\/ijmr.ijmr_296_19","type":"journal-article","created":{"date-parts":[[2020,10,17]],"date-time":"2020-10-17T05:25:10Z","timestamp":1602912310000},"page":"280-284","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":14,"title":["Prevalence of red blood cell antibodies in whole blood donors"],"prefix":"10.25259","volume":"152","author":[{"given":"Archana","family":"Solanki","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tulika","family":"Chandra","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashutosh","family":"Singh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"10894","reference":[{"key":"R4-12-20241212","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1179\/1607845412Y.0000000020","article-title":"Screening of blood donors for erythrocyte alloantibodies","volume":"17","author":"Pahuja","year":"2012","journal-title":"Hematology"},{"key":"R5-12-20241212","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1016\/j.transci.2014.03.004","article-title":"Prevalence of irregular red blood cell antibodies among healthy blood donors in Delhi population","volume":"50","author":"Garg","year":"2014","journal-title":"Transfus Apher Sci"},{"key":"R6-12-20241212","first-page":"EC12","article-title":"Erythrocyte alloimmunization and autoimmunization among blood donors and recipients visiting a tertiary care hospital","volume":"11","author":"Kaur","year":"2017","journal-title":"J Clin Diagn Res"},{"key":"R7-12-20241212","doi-asserted-by":"crossref","first-page":"17","DOI":"10.4103\/ajts.AJTS_4_17","article-title":"Prevalence of irregular red cell antibody in healthy blood donors attending a tertiary care hospital in North India","volume":"12","author":"Makroo","year":"2018","journal-title":"Asian J Transfus Sci"},{"key":"R8-12-20241212","doi-asserted-by":"crossref","first-page":"16","DOI":"10.4103\/0973-6247.106718","article-title":"Frequencies and specificities of red cell alloantibodies in the Southern Thai population","volume":"7","author":"Promwong","year":"2013","journal-title":"Asian J Transfus Sci"},{"key":"R9-12-20241212","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1111\/trf.15004","article-title":"Prevalence and risk factors for RBC alloantibodies in blood donors in the Recipient Epidemiology and Donor Evaluation Study-III (REDS-III)","volume":"59","author":"Karafin","year":"2019","journal-title":"Transfusion"},{"key":"R10-12-20241212","first-page":"194","article-title":"Red cell alloantibodies in Lao blood donors","volume":"45","author":"Keokhamphoui","year":"2014","journal-title":"Southeast Asian J Trop Med Public Health"},{"key":"R11-12-20241212","doi-asserted-by":"crossref","first-page":"4913","DOI":"10.21608\/ejhm.2018.10173","article-title":"Red blood cell alloantibodies in healthy Egyptian blood donors","volume":"72","author":"Hashem","year":"2018","journal-title":"Egypt J Hosp Med"},{"key":"R12-12-20241212","first-page":"42","article-title":"Multiple red cell transfusions and alloimmunization. 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