{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,2]],"date-time":"2025-07-02T23:40:04Z","timestamp":1751499604765,"version":"3.41.0"},"reference-count":16,"publisher":"Scientific Scholar","issue":"4","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2017,4]]},"abstract":"\n Background & objectives:<\/jats:title>\n Preoperative localization of parathyroid lesions is essential for improving the results in patients with primary hyperparathyroidism. The purpose of this study was to evaluate retrospectively the value of technetium-99m (Tc-99m) methoxyisobutylisonitrile (MIBI) single photon emission computed tomography (SPECT) and to compare the diagnostic accuracy of iterative reconstruction (IR) and filtered backprojection (FBP) reconstruction algorithms about localization of parathyroid lesions.<\/jats:p>\n <\/jats:sec>\n \n Methods:<\/jats:title>\n Forty four patients with primary hyperparathyroidism, in whom histopathological correlation could be performed, were included in the study. Dual-phase Tc-99m parathyroid scintigraphy was performed 20 and 120 min after injection of 740 MBq Tc-99m MIBI in all patients. Tomographic images were acquired 120 min after the administration of radiopharmaceutical. The SPECT data were evaluated using an IR as well as a FBP algorithm. In 23 of 44 patients, SPECT acquisitions were performed in 64\u00d764 matrix; in the remaining 21 patients, tomographic data were collected in 128\u00d7128 matrix. The imaging results were compared with pathological findings and sensitivities of both reconstruction algorithms, and planar views were calculated.<\/jats:p>\n <\/jats:sec>\n \n Results:<\/jats:title>\n Using planar MIBI scans, abnormal parathyroid glands were correctly localized in 75 per cent of the cases. Sensitivity increased to 77 per cent using SPECT with FBP and to 84 per cent with IR. When the sensitivities were calculated according to the acquisition matrix, these were 95 per cent (20\/21) and 85 per cent (18\/21) for IR and FBP, respectively in patients in whom 128\u00d7128 matrix was used. The sensitivities were lower in patients who were imaged with 64\u00d764 matrix; these were calculated as 74 per cent (17\/23) and 70 per cent (16\/23) with IR and FBP, respectively.<\/jats:p>\n <\/jats:sec>\n \n Interpretation & conclusions:<\/jats:title>\n Our findings showed that compared to planar scintigraphy, Tc-99m MIBI SPECT was more sensitive diagnostic modality in the detection of abnormal parathyroid tissues. Image quality and sensitivity may be improved further when larger matrices with IR are used instead of FBP algorithm.<\/jats:p>\n <\/jats:sec>","DOI":"10.4103\/ijmr.ijmr_305_15","type":"journal-article","created":{"date-parts":[[2024,12,19]],"date-time":"2024-12-19T19:02:25Z","timestamp":1734634945000},"page":"479-487","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":0,"title":["Influence of single photon emission computed tomography (SPECT) reconstruction algorithm on diagnostic accuracy of parathyroid scintigraphy"],"prefix":"10.25259","volume":"145","author":[{"given":"Gonca Kara","family":"Gedik","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Oktay","family":"Sari","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"10894","reference":[{"key":"R1-9-20241212","doi-asserted-by":"crossref","first-page":"1201","DOI":"10.1007\/s00259-009-1131-z","article-title":"2009 EANM parathyroid guidelines","volume":"36","author":"Hindi\u00e9","year":"2009","journal-title":"Eur J Nucl Med Mol Imaging"},{"key":"R2-9-20241212","doi-asserted-by":"crossref","first-page":"711","DOI":"10.1097\/00003072-200210000-00006","article-title":"Determinant role of Tc-99m MIBI SPECT in the localization of a retrotracheal parathyroid adenoma successfully treated by radioguided surgery","volume":"27","author":"Rubello","year":"2002","journal-title":"Clin Nucl Med"},{"key":"R3-9-20241212","first-page":"904","article-title":"Incremental diagnostic value of preoperative[99] mTc-MIBI SPECT in patients with a parathyroid adenoma","volume":"44","author":"Lorberboym","year":"2003","journal-title":"J Nucl Med"},{"key":"R4-9-20241212","first-page":"1773","article-title":"Advantages of SPECT in technetium-99m-sestamibi parathyroid scintigraphy","volume":"37","author":"Billotey","year":"1996","journal-title":"J Nucl Med"},{"key":"R5-9-20241212","doi-asserted-by":"crossref","first-page":"111","DOI":"10.2967\/jnmt.112.105122","article-title":"SNM practice guideline for parathyroid scintigraphy 4.0","volume":"40","author":"Greenspan","year":"2012","journal-title":"J Nucl Med Technol"},{"key":"R6-9-20241212","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1053\/j.semnuclmed.2006.03.003","article-title":"Parathyroid imaging: How good is it and how should it be done?","volume":"36","author":"Kettle","year":"2006","journal-title":"Semin Nucl Med"},{"key":"R7-9-20241212","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1067\/msy.2000.107066","article-title":"Technetium 99m-MIBI-SPECT: A highly sensitive diagnostic tool for localization of parathyroid adenomas","volume":"128","author":"Moka","year":"2000","journal-title":"Surgery"},{"key":"R8-9-20241212","doi-asserted-by":"crossref","first-page":"1471","DOI":"10.2214\/ajr.166.6.8633467","article-title":"Sestamibi SPECT scintigraphy for detection of postoperative hyperfunctional parathyroid glands","volume":"166","author":"Schurrer","year":"1996","journal-title":"AJR Am J Roentgenol"},{"key":"R9-9-20241212","doi-asserted-by":"crossref","first-page":"158","DOI":"10.3413\/nukmed-0108","article-title":"Preoperative localization of parathyroid lesions","volume":"47","author":"Ansguer","year":"2008","journal-title":"Nuklearmedizin"},{"key":"R10-9-20241212","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1007\/s002590050532","article-title":"Iterative reconstruction: An improvement of technetium-99m MIBI SPET for the detection of parathyroid adenomas?","volume":"27","author":"Moka","year":"2000","journal-title":"Eur J Nucl Med"},{"key":"R11-9-20241212","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1016\/j.zemedi.2011.04.007","article-title":"Comparison of advanced iterative reconstruction methods for SPECT\/CT","volume":"22","author":"Knoll","year":"2012","journal-title":"Z Med Phys"},{"key":"R12-9-20241212","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1097\/MNM.0000000000000020","article-title":"The influence of SPECT reconstruction algorithms on image quality and diagnostic accuracy in phantom measurements and[99] mTc-sestamibi parathyroid scintigraphy","volume":"35","author":"van Hoorn","year":"2014","journal-title":"Nucl Med Commun"},{"key":"R13-9-20241212","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1530\/eje.0.1490007","article-title":"Role of gamma probes in performing minimally invasive parathyroidectomy in patients with primary hyperparathyroidism: Optimization of preoperative and intraoperative procedures","volume":"149","author":"Rubello","year":"2003","journal-title":"Eur J Endocrinol"},{"key":"R14-9-20241212","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1097\/00006231-200302000-00003","article-title":"Biological factors influencing parathyroid localization","volume":"24","author":"Pons","year":"2003","journal-title":"Nucl Med Commun"},{"key":"R15-9-20241212","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1053\/j.semnuclmed.2005.06.001","article-title":"Radionuclide imaging of the parathyroid glands","volume":"35","author":"Palestro","year":"2005","journal-title":"Semin Nucl Med"},{"key":"R16-9-20241212","first-page":"1537","article-title":"Detection of P-glycoprotein activity in endotoxemic rats by[99] mTc-sestamibi imaging","volume":"46","author":"Wang","year":"2005","journal-title":"J Nucl Med"}],"container-title":["Indian Journal of Medical Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.lww.com\/02223309-201745040-00009","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,7,2]],"date-time":"2025-07-02T22:58:44Z","timestamp":1751497124000},"score":1,"resource":{"primary":{"URL":"https:\/\/ijmr.org.in\/influence-of-single-photon-emission-computed-tomography-spect-reconstruction-algorithm-on-diagnostic-accuracy-of-parathyroid-scintigraphy-comparison-of-iterative-reconstruction-with-filtered-backpr\/"}},"subtitle":["Comparison of iterative reconstruction with filtered backprojection"],"short-title":[],"issued":{"date-parts":[[2017,4]]},"references-count":16,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2017]]}},"URL":"https:\/\/doi.org\/10.4103\/ijmr.ijmr_305_15","relation":{},"ISSN":["0971-5916"],"issn-type":[{"type":"print","value":"0971-5916"}],"subject":[],"published":{"date-parts":[[2017,4]]}}}