{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,19]],"date-time":"2026-03-19T10:58:59Z","timestamp":1773917939312,"version":"3.50.1"},"reference-count":30,"publisher":"Scientific Scholar","issue":"6","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2018,12]]},"abstract":"\n Background & objectives:<\/jats:title>\n The frequency and predictors of pancreatitis in primary hyperparathyroidism (PHPT) are not well understood. The objective of the present study was to evaluate the frequency of pancreatitis in patients with PHPT and its association with clinical and biochemical parameters of the disease.<\/jats:p>\n <\/jats:sec>\n \n Methods:<\/jats:title>\n In this retrospective study all consecutive patients with PHPT registered in the PHPT registry (http:\/\/www.indianphptregistry.com) from the year 2004 to 2013 were included. The clinical, biochemical and radiological parameters related to pancreatitis were evaluated in histologically proven PHPT patients.<\/jats:p>\n <\/jats:sec>\n \n Results:<\/jats:title>\n A total of 218 patients (63 men; mean age: 40.6\u00b114.4 yr) underwent surgery for PHPT during the study. Pancreatitis occurred in 35 [16%, 18 acute and 17 chronic pancreatitis (CP)] patients and male:female ratio was 1:0.94. Skeletal manifestations were seen less frequently in PHPT with pancreatitis as compared to that of PHPT without pancreatitis. PHPT with pancreatitis had significantly higher serum calcium (12.4\u00b12.0 vs. 11.7\u00b11.5 mg\/dl, P<\/jats:italic><0.05) in comparison to PHPT without pancreatitis. PHPT with acute pancreatitis (AP) had higher serum calcium (P<\/jats:italic><0.05) and parathyroid hormone (PTH) (P<\/jats:italic><0.05) levels than PHPT with CP. Curative parathyroidectomy improved the symptoms associated with pancreatitis as there was no recurrence in AP group, whereas recurrence was observed only in about 10 per cent patients of the CP group.<\/jats:p>\n <\/jats:sec>\n \n Interpretation & conclusions:<\/jats:title>\n Pancreatitis was observed in 16 per cent of PHPT patients with male predominance in the study population. No recurrence of AP was observed after curative surgery. It may be proposed that serum amylase with calcium and PTH should be measured in all patients of PHPT with pain abdomen to rule out pancreatitis.<\/jats:p>\n <\/jats:sec>","DOI":"10.4103\/ijmr.ijmr_353_16","type":"journal-article","created":{"date-parts":[[2019,2,12]],"date-time":"2019-02-12T13:43:27Z","timestamp":1549979007000},"page":"721-727","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":19,"title":["Frequency & predictors of pancreatitis in symptomatic primary hyperparathyroidism"],"prefix":"10.25259","volume":"148","author":[{"given":"Ashutosh Kumar","family":"Arya","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sanjay Kumar","family":"Bhadada","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Soham","family":"Mukherjee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Priyanka","family":"Singh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Surinder S.","family":"Rana","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Divya","family":"Dahiya","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ashwani","family":"Sood","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Uma Nahar","family":"Saikia","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mahesh","family":"Prakash","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Deepak Kumar","family":"Bhasin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arunanshu","family":"Behera","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rama","family":"Walia","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anil","family":"Bhansali","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"10894","reference":[{"key":"R1-9-20241212","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/S0140-6736(09)60507-9","article-title":"Hyperparathyroidism","volume":"374","author":"Fraser","year":"2009","journal-title":"Lancet"},{"key":"R2-9-20241212","first-page":"694","article-title":"Changes in clinical & biochemical presentations of primary hyperparathyroidism in India over a period of 20 years","volume":"139","author":"Shah","year":"2014","journal-title":"Indian J Med Res"},{"key":"R3-9-20241212","doi-asserted-by":"crossref","first-page":"721","DOI":"10.1210\/jc.2012-2914","article-title":"The changing clinical patterns of primary hyperparathyroidism in Chinese patients: Data from 2000 to 2010 in a single clinical center","volume":"98","author":"Zhao","year":"2013","journal-title":"J Clin Endocrinol Metab"},{"key":"R4-9-20241212","doi-asserted-by":"crossref","first-page":"107","DOI":"10.4103\/0022-3859.97171","article-title":"Influence of age and gender on presentation of symptomatic primary hyperparathyroidism","volume":"58","author":"Shah","year":"2012","journal-title":"J Postgrad Med"},{"key":"R5-9-20241212","doi-asserted-by":"crossref","first-page":"3580","DOI":"10.1210\/jc.2014-1415","article-title":"Current issues in the presentation of asymptomatic primary hyperparathyroidism: Proceedings of the fourth international workshop","volume":"99","author":"Silverberg","year":"2014","journal-title":"J Clin Endocrinol Metab"},{"key":"R6-9-20241212","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1007\/s00774-017-0833-8","article-title":"Primary hyperparathyroidism: Insights from the Indian PHPT registry","volume":"36","author":"Bhadada","year":"2018","journal-title":"J Bone Miner Metab"},{"key":"R7-9-20241212","first-page":"224","article-title":"Pancreatitis in patients with primary hyperparathyroidism","volume":"22","author":"Agarwal","year":"2003","journal-title":"Indian J Gastroenterol"},{"key":"R8-9-20241212","doi-asserted-by":"crossref","first-page":"959","DOI":"10.1111\/j.1440-1746.2007.05050.x","article-title":"Chronic pancreatitis in primary hyperparathyroidism: Comparison with alcoholic and idiopathic chronic pancreatitis","volume":"23","author":"Bhadada","year":"2008","journal-title":"J Gastroenterol Hepatol"},{"key":"R9-9-20241212","doi-asserted-by":"crossref","first-page":"484","DOI":"10.1007\/s12664-014-0470-2","article-title":"Primary hyperparathyroidism with pancreatitis: Experience of management in 5 patients with review of literature","volume":"33","author":"Gupta","year":"2014","journal-title":"Indian J Gastroenterol"},{"key":"R10-9-20241212","doi-asserted-by":"crossref","first-page":"740","DOI":"10.1111\/j.1445-2197.2006.03845.x","article-title":"Does hyperparathyroidism cause pancreatitis? A South Indian experience and a review of published work","volume":"76","author":"Jacob","year":"2006","journal-title":"ANZ J Surg"},{"key":"R11-9-20241212","doi-asserted-by":"crossref","first-page":"2959","DOI":"10.3748\/wjg.v16.i23.2959","article-title":"Acute necrotizing pancreatitis as first manifestation of primary hyperparathyroidism","volume":"16","author":"Lenz","year":"2010","journal-title":"World J Gastroenterol"},{"key":"R12-9-20241212","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1111\/j.1445-2197.1998.tb04719.x","article-title":"Pancreatitis and primary hyperparathyroidism: Forty cases","volume":"68","author":"Carnaille","year":"1998","journal-title":"Aust N Z J Surg"},{"key":"R13-9-20241212","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1002\/bjs.1800750224","article-title":"Pancreatitis and hyperparathyroidism","volume":"75","author":"Sitges-Serra","year":"1988","journal-title":"Br J Surg"},{"key":"R14-9-20241212","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1111\/j.1445-2197.1996.tb01117.x","article-title":"Hyperparathyroidism presenting as pancreatitis or complicated by postoperative pancreatitis","volume":"66","author":"Shepherd","year":"1996","journal-title":"Aust N Z J Surg"},{"key":"R15-9-20241212","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1055\/s-2008-1058752","article-title":"Pancreatitis in primary hyperparathyroidism (pHPT) is a complication of advanced pHPT","volume":"119","author":"Koppelberg","year":"1994","journal-title":"Dtsch Med Wochenschr"},{"key":"R16-9-20241212","first-page":"279","article-title":"Effect of gender, biochemical parameters & parathyroid surgery on gastrointestinal manifestations of symptomatic primary hyperparathyroidism","volume":"139","author":"Shah","year":"2014","journal-title":"Indian J Med Res"},{"key":"R17-9-20241212","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1007\/s12664-013-0430-2","article-title":"Acute pancreatitis and hyperparathyroidism: A case series","volume":"33","author":"Chowdhury","year":"2014","journal-title":"Indian J Gastroenterol"},{"key":"R18-9-20241212","doi-asserted-by":"crossref","first-page":"100","DOI":"10.4103\/2230-8210.131763","article-title":"Primary hyperparathyroidism presenting as hypercalcemic crisis: Twenty-year experience","volume":"19","author":"Singh","year":"2015","journal-title":"Indian J Endocrinol Metab"},{"key":"R19-9-20241212","doi-asserted-by":"crossref","first-page":"2379","DOI":"10.1111\/j.1572-0241.2006.00856.x","article-title":"Practice guidelines in acute pancreatitis","volume":"101","author":"Banks","year":"2006","journal-title":"Am J Gastroenterol"},{"key":"R20-9-20241212","doi-asserted-by":"crossref","first-page":"1184","DOI":"10.1016\/S0140-6736(10)61852-1","article-title":"Chronic pancreatitis","volume":"377","author":"Braganza","year":"2011","journal-title":"Lancet"},{"key":"R21-9-20241212","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1097\/00006676-199201000-00009","article-title":"Comparative study of the clinical profiles of alcoholic chronic pancreatitis and tropical chronic pancreatitis in Tamil Nadu, South India","volume":"7","author":"Chari","year":"1992","journal-title":"Pancreas"},{"key":"R22-9-20241212","doi-asserted-by":"crossref","first-page":"488","DOI":"10.1067\/mge.2002.122651","article-title":"Endotherapy of early onset idiopathic chronic pancreatitis: Results with long-term follow-up","volume":"55","author":"Gabbrielli","year":"2002","journal-title":"Gastrointest Endosc"},{"key":"R23-9-20241212","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1111\/j.1572-0241.2007.01695.x","article-title":"Pancreatitis risk in primary hyperparathyroidism: Relation to mutations in the SPINK1 trypsin inhibitor (N34S) and the cystic fibrosis gene","volume":"103","author":"Felderbauer","year":"2008","journal-title":"Am J Gastroenterol"},{"key":"R24-9-20241212","doi-asserted-by":"crossref","first-page":"2115","DOI":"10.1210\/jc.2008-1965","article-title":"Acute pancreatitis in primary hyperparathyroidism: A population-based study","volume":"94","author":"Khoo","year":"2009","journal-title":"J Clin Endocrinol Metab"},{"key":"R25-9-20241212","doi-asserted-by":"crossref","first-page":"5","DOI":"10.4103\/0972-3919.116796","article-title":"Parathyroid scintigraphy, histopathology correlation in patients with tropical pancreatitis and coexisting primary hyperparathyroidism","volume":"28","author":"Padma","year":"2013","journal-title":"Indian J Nucl Med"},{"key":"R26-9-20241212","first-page":"1344","article-title":"Chronic pancreatitis and primary hyperparathyroidism","volume":"124","author":"Bauer","year":"1994","journal-title":"Schweiz Med Wochenschr"},{"key":"R27-9-20241212","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1016\/0016-5085(95)90290-2","article-title":"Acute hypercalcemia causes acute pancreatitis and ectopic trypsinogen activation in the rat","volume":"109","author":"Mith\u00f6fer","year":"1995","journal-title":"Gastroenterology"},{"key":"R28-9-20241212","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1136\/gut.41.3.339","article-title":"Elevated calcium and activation of trypsinogen in rat pancreatic acini","volume":"41","author":"Frick","year":"1997","journal-title":"Gut"},{"key":"R29-9-20241212","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1055\/s-0030-1255106","article-title":"Multifactorial genesis of pancreatitis in primary hyperparathyroidism: Evidence for \u201cprotective\u201d (PRSS2) and \u201cdestructive\u201d (CTRC) genetic factors","volume":"119","author":"Felderbauer","year":"2011","journal-title":"Exp Clin Endocrinol Diabetes"},{"key":"R30-9-20241212","doi-asserted-by":"crossref","first-page":"614","DOI":"10.1111\/cen.12479","article-title":"Changes in parathyroid proteome in patients with primary hyperparathyroidism due to sporadic parathyroid adenomas","volume":"81","author":"Varshney","year":"2014","journal-title":"Clin Endocrinol (Oxf"}],"container-title":["Indian Journal of Medical Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.lww.com\/02223309-201848060-00009","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,7,2]],"date-time":"2025-07-02T13:50:57Z","timestamp":1751464257000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.lww.com\/02223309-201848060-00009"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,12]]},"references-count":30,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2018]]}},"URL":"https:\/\/doi.org\/10.4103\/ijmr.ijmr_353_16","relation":{},"ISSN":["0971-5916"],"issn-type":[{"value":"0971-5916","type":"print"}],"subject":[],"published":{"date-parts":[[2018,12]]}}}