{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T20:38:00Z","timestamp":1792183080565,"version":"4.4.0"},"reference-count":19,"publisher":"Scientific Scholar","issue":"2","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2023,8]]},"abstract":"\n Background & objectives:<\/jats:title>\n During the course of a retrospective survey on healthcare associated infections (HAIs) due to carbapenem-resistant organisms, an unusual prevalence of HAIs due to carbapenem-resistant Providencia stuartii<\/jats:italic> (CRPS) was found. Hence this study aimed to conduct the occurrence of P. stuartii<\/jats:italic> associated HAIs with special reference to the drug resistance profiling of these isolates.<\/jats:p>\n <\/jats:sec>\n \n Methods:<\/jats:title>\n Of the eight total HAI cases (7.5% of total HAIs and 33.3% of HAIs due to Enterobacterales) of CRPS infections included in this study, three were reported from ventilator-associated pneumonia (VAP), three were surgical site infections (SSIs), one was a catheter-associated urinary tract infection (CAUTI) and one was a bloodstream infection. All the eight CRPS isolates were tested for extended-spectrum \u03b2-lactamases production, AmpC hyperproduction as well as carbapenem resistance. Typing of the isolates was performed by repetitive extragenic palindromic polymerase chain reaction (REP-PCR).<\/jats:p>\n <\/jats:sec>\n \n Results:<\/jats:title>\n All the eight isolates of CRPS were found to be AmpC hyperproducers, carbapenemase producers, and harboured chromosomally located bla<\/jats:italic>\n NDM<\/jats:sub> in seven isolates and bla<\/jats:italic>\n IMP<\/jats:sub> genes in one. All the cases with CRPS infections had prior history of colistin therapy along with prolonged hospital stay (>20 days). The cases were located in five different wards\/intensive care unit (ICU) within the hospital in one year. However, strain typing by REP-PCR revealed 100 per cent similarity and clonal relatedness in all the seven isolates carrying bla<\/jats:italic>\n NDM<\/jats:sub> genes. Interestingly, routine hospital surveillance revealed a high carriage of P. stuartii<\/jats:italic> in the axilla of patients admitted to the ICU.<\/jats:p>\n <\/jats:sec>\n \n Interpretation & conclusions:<\/jats:title>\n The study findings suggest CRPS as an important cause of HAIs. This organism often goes unnoticed due to the burden of carbapenem resistance in other Enterobacterales and non-fermenters.<\/jats:p>\n <\/jats:sec>","DOI":"10.4103\/ijmr.ijmr_3668_20","type":"journal-article","created":{"date-parts":[[2024,4,16]],"date-time":"2024-04-16T07:00:24Z","timestamp":1713250824000},"page":"145-150","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":8,"title":["Hospital-acquired infections due to carbapenem-resistant Providencia stuartii"],"prefix":"10.25259","volume":"158","author":[{"given":"Swati","family":"Sharma","sequence":"first","affiliation":[{"name":"Department of Microbiology, Institute of Medical Sciences, Banaras Hindu University, Varanasi, Uttar Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sangita","family":"Pramanik","sequence":"additional","affiliation":[{"name":"Department of Botany, Institute of Science, Banaras Hindu University, Varanasi, Uttar 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