{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,2]],"date-time":"2025-07-02T23:40:04Z","timestamp":1751499604448,"version":"3.41.0"},"reference-count":19,"publisher":"Scientific Scholar","issue":"3","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2022,9]]},"abstract":"\n Background & objectives:<\/jats:title>\n In clinical settings, peripheral blood pressure (PBP) is measured routinely. It is thought that central blood pressure (CBP) which reflects aortic BP, may be more predictive of outcomes in specific populations. Hence, this study was carried out to measure CBP in patients with hypertension and to see the effect of antihypertensive drugs on CBP.<\/jats:p>\n <\/jats:sec>\n \n Methods:<\/jats:title>\n This cross-sectional study was conducted on 134 hypertensive patients and 134 normotensive healthy individuals as controls. Peripheral BPs and CBPs were measured of all patients and controls. The data were correlated and the effect of antihypertensive drugs on CBP was also evaluated.<\/jats:p>\n <\/jats:sec>\n \n Results:<\/jats:title>\n Of the 134 hypertensive patients, 44 (32.84%) were newly diagnosed and the rest 90 (67.16%) had a history of hypertension and were on treatment. Of these 90 patients on treatment, 37 (41.11%) had uncontrolled peripheral BP and 53 (58.89%) had normal peripheral BP. Of the 134 hypertensive patients, 45 (33.58%) had controlled CBP. In 90 patients, who were on antihypertensive treatment, 45 (50%) had controlled CBP and 45 (50%) had uncontrolled CBP. Patients on calcium channel blockers (CCBs) had better control of CBP.<\/jats:p>\n <\/jats:sec>\n \n Interpretation & conclusions:<\/jats:title>\n Hypertension is diagnosed mainly by measuring peripheral BP. CBP, which correlates better with the incidence of cardiovascular events, is not routinely measured. Patients with a history of hypertension and on treatment had normal office peripheral BP, but a few of them had high CBP and may require modification in treatment for control of CBP. Control of CBP was better in patients taking CCB.<\/jats:p>\n <\/jats:sec>","DOI":"10.4103\/ijmr.ijmr_608_20","type":"journal-article","created":{"date-parts":[[2024,4,16]],"date-time":"2024-04-16T07:05:07Z","timestamp":1713251107000},"page":"524-528","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":1,"title":["Study of central aortic blood pressure in hypertensive patients & its relation with blood pressure-lowering drugs"],"prefix":"10.25259","volume":"156","author":[{"given":"Dhyanendra","family":"Sachan","sequence":"first","affiliation":[{"name":"Department of Pulmonary & Critical Care Medicine, Lucknow, Uttar Pradesh, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kamal Kumar","family":"Sawlani","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, King George\u2019s Medical University, Lucknow, Uttar Pradesh, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amit","family":"Kumar","sequence":"additional","affiliation":[{"name":"Department of Pulmonary & Critical Care Medicine, Lucknow, Uttar Pradesh, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shyam Chand","family":"Chaudhary","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, King George\u2019s Medical University, Lucknow, Uttar Pradesh, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Himanshu","family":"Dandu","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, King George\u2019s Medical University, Lucknow, Uttar Pradesh, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kauser","family":"Usman","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, King George\u2019s Medical University, Lucknow, Uttar Pradesh, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Virendra","family":"Atam","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, King George\u2019s Medical University, Lucknow, Uttar Pradesh, India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"10894","published-online":{"date-parts":[[2023,2,3]]},"reference":[{"key":"R1-20241212","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1001\/jama.2013.284427","article-title":"2014 evidence-based guideline for the management of high blood pressure in adults:Report from the panel members appointed to the Eighth Joint National Committee (JNC 8)","volume":"311","author":"James","year":"2014","journal-title":"JAMA"},{"key":"R2-20241212","doi-asserted-by":"crossref","first-page":"1953","DOI":"10.1097\/HJH.0000000000001940","article-title":"2018 ESC\/ESH guidelines for the management of arterial hypertension:The Task Force for the management of arterial hypertension of the European Society of Cardiology and the European Society of Hypertension. The Task Force for the management of arterial hypertension of the European Society of Cardiology and the European Society of Hypertension","volume":"36","author":"Williams","year":"2018","journal-title":"J Hypertens"},{"key":"R3-20241212","doi-asserted-by":"crossref","first-page":"1923","DOI":"10.1016\/S0140-6736(18)32225-6","article-title":"Global, regional, and national comparative risk assessment of 84 behavioural, environmental and occupational, and metabolic risks or clusters of risks for 195 countries and territories, 1990-2017:A systematic analysis for the Global Burden of Disease Study 2017","volume":"392","year":"2018","journal-title":"Lancet"},{"key":"R4-20241212","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1038\/ajh.2009.255","article-title":"Cross-sectional characterization of all classes of antihypertensives in terms of central blood pressure in Japanese hypertensive patients","volume":"23","author":"Miyashita","year":"2010","journal-title":"Am J Hypertens"},{"key":"R5-20241212","doi-asserted-by":"crossref","first-page":"980","DOI":"10.1161\/01.HYP.0000165025.16381.44","article-title":"Aortic pressure augmentation predicts adverse cardiovascular events in patients with established coronary artery disease","volume":"45","author":"Chirinos","year":"2005","journal-title":"Hypertension"},{"key":"R6-20241212","doi-asserted-by":"crossref","first-page":"1213","DOI":"10.1161\/CIRCULATIONAHA.105.595496","article-title":"Differential impact of blood pressure-lowering drugs on central aortic pressure and clinical outcomes:Principal results of the Conduit Artery Function Evaluation (CAFE) study","volume":"113","author":"Williams","year":"2006","journal-title":"Circulation"},{"key":"R7-20241212","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1097\/HJH.0b013e32835ac7b5","article-title":"Association between urinary albumin excretion and both central and peripheral blood pressure in subjects with insulin resistance","volume":"31","author":"Oliveras","year":"2013","journal-title":"J Hypertens"},{"key":"R8-20241212","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1097\/HJH.0b013e328333d228","article-title":"Relations of central and brachial blood pressure to left ventricular hypertrophy and geometry:The Strong Heart Study","volume":"28","author":"Roman","year":"2010","journal-title":"J Hypertens"},{"key":"R9-20241212","doi-asserted-by":"crossref","first-page":"R1","DOI":"10.1088\/0967-3334\/31\/1\/R01","article-title":"Arterial blood pressure measurement and pulse wave analysis \u2013Their role in enhancing cardiovascular assessment","volume":"31","author":"Avolio","year":"2010","journal-title":"Physiol Meas"},{"key":"R10-20241212","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1097\/HJH.0b013e3283220ea4","article-title":"Central or peripheral systolic or pulse pressure:Which best relates to target-organs and future mortality?","volume":"27","author":"Wang","year":"2009","journal-title":"J Hypertens"},{"key":"R11-20241212","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1097\/HJH.0b013e32834fa8b0","article-title":"Expert consensus document on the measurement of aortic stiffness in daily practice using carotid-femoral pulse wave velocity","volume":"30","author":"Van Bortel","year":"2012","journal-title":"J Hypertens"},{"key":"R12-20241212","doi-asserted-by":"crossref","first-page":"735","DOI":"10.1161\/hy0202.098325","article-title":"Central pulse pressure and mortality in end-stage renal disease","volume":"39","author":"Safar","year":"2002","journal-title":"Hypertension"},{"key":"R13-20241212","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1161\/HYPERTENSIONAHA.107.090068","article-title":"Central blood pressure measurements and antihypertensive therapy:A consensus document","volume":"50","author":"Agabiti-Rosei","year":"2007","journal-title":"Hypertension"},{"key":"R14-20241212","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1161\/HYPERTENSIONAHA.107.089078","article-title":"Central pressure more strongly relates to vascular disease and outcome than does brachial pressure:The Strong Heart Study","volume":"50","author":"Roman","year":"2007","journal-title":"Hypertension"},{"key":"R15-20241212","doi-asserted-by":"crossref","first-page":"653239","DOI":"10.1155\/2014\/653239","article-title":"Reference values of pulse wave velocity in healthy people from an urban and rural argentinean population","volume":"2014","author":"D\u00edaz","year":"2014","journal-title":"Int J Hypertens"},{"key":"R16-20241212","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1161\/CIRCULATIONAHA.109.886655","article-title":"Arterial stiffness and cardiovascular events:The Framingham Heart Study","volume":"121","author":"Mitchell","year":"2010","journal-title":"Circulation"},{"key":"R17-20241212","doi-asserted-by":"crossref","first-page":"922","DOI":"10.1161\/hy1001.095774","article-title":"Improvement in blood pressure, arterial stiffness and wave reflections with a very-low-dose perindopril\/indapamide combination in hypertensive patient:A comparison with atenolol","volume":"38","author":"Asmar","year":"2001","journal-title":"Hypertension"},{"key":"R18-20241212","doi-asserted-by":"crossref","first-page":"384","DOI":"10.11622\/smedj.2016040","article-title":"Effect of angiotensin receptor blockade on central aortic systolic blood pressure in hypertensive Asians measured using radial tonometry:An open prospective cohort study","volume":"57","author":"Teong","year":"2016","journal-title":"Singapore Med J"},{"key":"R19-20241212","doi-asserted-by":"crossref","first-page":"724","DOI":"10.1161\/HYPERTENSIONAHA.108.125740","article-title":"Differences in the magnitude of wave reflection account for differential effects of amlodipine- versus atenolol-based regimens on central blood pressure:An Anglo-Scandinavian Cardiac Outcome Trial substudy","volume":"54","author":"Manisty","year":"2009","journal-title":"Hypertension"}],"container-title":["Indian Journal of Medical Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.lww.com\/10.4103\/ijmr.IJMR_608_20","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,7,2]],"date-time":"2025-07-02T23:05:29Z","timestamp":1751497529000},"score":1,"resource":{"primary":{"URL":"https:\/\/ijmr.org.in\/study-of-central-aortic-blood-pressure-in-hypertensive-patients-its-relation-with-blood-pressure-lowering-drugs\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,9]]},"references-count":19,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2022]]}},"URL":"https:\/\/doi.org\/10.4103\/ijmr.ijmr_608_20","relation":{},"ISSN":["0971-5916","0975-9174"],"issn-type":[{"type":"print","value":"0971-5916"},{"type":"electronic","value":"0975-9174"}],"subject":[],"published":{"date-parts":[[2022,9]]},"assertion":[{"value":"2020-03-07","name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}}]}}