{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T21:52:16Z","timestamp":1790718736291,"version":"4.1.0"},"reference-count":28,"publisher":"Scientific Scholar","issue":"2","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2018,8]]},"abstract":"<jats:sec>\n                    <jats:title\/>\n                    <jats:p>Kyasanur forest disease (KFD) is a known viral haemorrhagic fever in India, for the last 60 years. However, in recent years, the change in epidemiological profile of the disease has suggested that it is now time to consider KFD as an emerging tropical disease in India. The preference should be to educate not only the villagers where it is being reported or detected but also to public health experts, veterinarians, forest officials and medical professionals to pay attention while seeing a patient overlapping with endemic diseases such as Japanese encephalitis, West Nile, dengue, chikungunya, malaria and tuberculosis. Although the existence of KFD is known for a long time, updated understanding of its clinical profile in humans is still limited. This article describes in detail the clinical presentation of KFD reported till date. It also highlights geographical distribution of the disease, risk factors for virus transmission, biochemical\/haematological findings and control measures. There is an urgent need for research on KFD, particularly for understanding biphasic nature of illness, development of cost-effective diagnostic tools, utility of non-invasive samples for diagnosis and development of new vaccines.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/ijmr.ijmr_688_17","type":"journal-article","created":{"date-parts":[[2018,10,19]],"date-time":"2018-10-19T00:55:27Z","timestamp":1539910527000},"page":"145-150","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":72,"title":["Clinical &amp; epidemiological significance of Kyasanur forest disease"],"prefix":"10.25259","volume":"148","author":[{"given":"Ashok","family":"Munivenkatappa","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rima Rakesh","family":"Sahay","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pragya D.","family":"Yadav","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rajalakshmi","family":"Viswanathan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Devendra T.","family":"Mourya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"10894","reference":[{"key":"R1-5-20241212","first-page":"341","article-title":"Kyasanur forest disease, a new virus disease in India","volume":"11","author":"Work","year":"1957","journal-title":"Indian J Med Sci"},{"key":"R2-5-20241212","first-page":"248","article-title":"Russian spring-summer virus in India: Kyasanur forest disease","volume":"1","author":"Work","year":"1958","journal-title":"Prog Med Virol"},{"key":"R3-5-20241212","first-page":"1011","article-title":"Kyasanur forest disease VI. Pathological findings in three fatal human cases of Kyasanur forest disease","volume":"13","author":"Iyer","year":"1959","journal-title":"Indian J Med Res"},{"key":"R4-5-20241212","first-page":"619","article-title":"Kyasanur forest disease. III. A preliminary report on the nature of the infection and clinical manifestations in human beings","volume":"11","author":"Work","year":"1957","journal-title":"Indian J Med Sci"},{"key":"R5-5-20241212","doi-asserted-by":"crossref","first-page":"S854","DOI":"10.1093\/clinids\/11.Supplement_4.S854","article-title":"Clinical, clinicopathologic, and hematologic features of Kyasanur forest disease","volume":"11","author":"Pavri","year":"1989","journal-title":"Rev Infect Dis"},{"key":"R10-5-20241212","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1016\/j.antiviral.2012.10.005","article-title":"Kyasanur forest disease","volume":"96","author":"Holbrook","year":"2012","journal-title":"Antiviral Res"},{"key":"R11-5-20241212","first-page":"124","article-title":"Clinical study of 100 cases of KFD clinic pathological correlation","volume":"47","author":"Adhikari Prabhe","year":"1993","journal-title":"Indian J Med Sci"},{"key":"R12-5-20241212","doi-asserted-by":"crossref","first-page":"329","DOI":"10.14737\/journal.aavs\/2014\/2.6.329.336","article-title":"Kyasanur forest disease: A status update","volume":"4","author":"John","year":"2014","journal-title":"Adv Anim Vet Sci"},{"key":"R13-5-20241212","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1002\/rmv.495","article-title":"Kyasanur forest disease: An epidemiological view in India","volume":"16","author":"Pattnaik","year":"2006","journal-title":"Rev Med Virol"},{"key":"R14-5-20241212","first-page":"1011","article-title":"Kyasanur forest disease VI. Pathological findings in three fatal human cases of Kyasanur forest disease","volume":"13","author":"Iyer","year":"1959","journal-title":"Indian J Med Sci"},{"key":"R15-5-20241212","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1007\/s40475-016-0067-1","article-title":"Recent scenario of emergence of Kyasanur forest disease in India and public health importance","volume":"3","author":"Mourya","year":"2016","journal-title":"Curr Trop Med Rep"},{"key":"R17-5-20241212","doi-asserted-by":"crossref","first-page":"278","DOI":"10.3201\/eid1902.120544","article-title":"Kyasanur forest disease, India, 2011-2012","volume":"19","author":"Kasabi","year":"2013","journal-title":"Emerg Infect Dis"},{"key":"R18-5-20241212","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1016\/0035-9203(61)90067-0","article-title":"Kyasanur forest disease: A general clinical study in which some cases with neurological complications were observed","volume":"55","author":"Webb","year":"1961","journal-title":"Trans R Soc Trop Med Hyg"},{"key":"R19-5-20241212","first-page":"115","article-title":"Neurological involvement in Kyasanur forest disease","volume":"23","author":"Wadia","year":"1975","journal-title":"Neurol India"},{"key":"R21-5-20241212","doi-asserted-by":"crossref","first-page":"869","DOI":"10.2105\/AJPH.49.7.869","article-title":"Virological epidemiology of the 1958 epidemic of Kyasanur forest disease","volume":"49","author":"Work","year":"1959","journal-title":"Am J Public Health Nations Health"},{"key":"R23-5-20241212","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/j.jviromet.2012.07.019","article-title":"Diagnosis of Kyasanur forest disease by nested RT-PCR, real-time RT-PCR and IgM capture ELISA","volume":"186","author":"Mourya","year":"2012","journal-title":"J Virol Methods"},{"key":"R24-5-20241212","first-page":"8","article-title":"Expediency of dengue illness classification: The Sri Lankan perspective highly infectious tick-borne viral diseases: Kyasanur forest disease and Crimean-Congo haemorrhagic fever in India. WHO South East","volume":"3","author":"Mourya","year":"2014","journal-title":"Asia J Public Health"},{"key":"R25-5-20241212","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1186\/s40249-015-0066-9","article-title":"On the transmission pattern of Kyasanur forest disease (KFD) in India","volume":"4","author":"Murhekar","year":"2015","journal-title":"Infect Dis Poverty"},{"key":"R29-5-20241212","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1186\/s40249-015-0044-2","article-title":"New focus of Kyasanur forest disease virus activity in a tribal area in Kerala, India, 2014","volume":"4","author":"Tandale","year":"2015","journal-title":"Infect Dis Poverty"},{"key":"R30-5-20241212","doi-asserted-by":"crossref","first-page":"1540","DOI":"10.3201\/eid1909.121884","article-title":"Spread of Kyasanur forest disease, Bandipur Tiger Reserve, India, 2012-2013","volume":"19","author":"Mourya","year":"2013","journal-title":"Emerg Infect Dis"},{"key":"R31-5-20241212","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1016\/j.ijid.2014.05.013","article-title":"Outbreak of Kyasanur forest disease in Thirthahalli, Karnataka, India, 2014","volume":"26","author":"Yadav","year":"2014","journal-title":"Int J Infect Dis"},{"key":"R33-5-20241212","first-page":"573","article-title":"Observations on the experimental exposure of monkeys, rodents and shrews to infestation of ticks in forest in Kyasanur forest diseases area","volume":"56","author":"Boshell","year":"1968","journal-title":"Indian J Med Res"},{"key":"R35-5-20241212","first-page":"794","article-title":"A serological survey of arboviral diseases among the human population of the Andaman and Nicobar Islands, India","volume":"33","author":"Padbidri","year":"2002","journal-title":"Southeast Asian J Trop Med Public Health"},{"key":"R36-5-20241212","doi-asserted-by":"crossref","first-page":"47","DOI":"10.4103\/0019-557X.200262","article-title":"Preliminary risk maps for transmission of Kyasanur forest disease in Southern India","volume":"61","author":"Peterson","year":"2017","journal-title":"Indian J Public Health"},{"key":"R37-5-20241212","first-page":"80","article-title":"Kyasanur Forest Disease: A new infection of man & monkeys in tropical India by a virus of the Russian Spring-Summer complex.Proc","volume":"17","author":"Work","year":"1957","journal-title":"Ninth Pacific Science Congress"},{"key":"R39-5-20241212","first-page":"79","article-title":"Upcoming and future strategies of tick control: A review","volume":"44","author":"Ghosh","year":"2007","journal-title":"J Vector Borne Dis"},{"key":"R40-5-20241212","doi-asserted-by":"crossref","first-page":"146","DOI":"10.3201\/eid2101.141227","article-title":"Kyasanur forest disease outbreak and vaccination strategy, Shimoga district, India, 2013-2014","volume":"21","author":"Kiran","year":"2015","journal-title":"Emerg Infect Dis"},{"key":"R41-5-20241212","doi-asserted-by":"crossref","first-page":"e2025","DOI":"10.1371\/journal.pntd.0002025","article-title":"Coverage and effectiveness of Kyasanur forest disease (KFD) vaccine in Karnataka, South India, 2005-10","volume":"7","author":"Kasabi","year":"2013","journal-title":"PLoS Negl Trop Dis"}],"container-title":["Indian Journal of Medical Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.lww.com\/02223309-201848020-00005","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,7,2]],"date-time":"2025-07-02T19:00:35Z","timestamp":1751482835000},"score":1,"resource":{"primary":{"URL":"https:\/\/ijmr.org.in\/clinical-epidemiological-significance-of-kyasanur-forest-disease\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,8]]},"references-count":28,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2018]]}},"URL":"https:\/\/doi.org\/10.4103\/ijmr.ijmr_688_17","relation":{},"ISSN":["0971-5916"],"issn-type":[{"value":"0971-5916","type":"print"}],"subject":[],"published":{"date-parts":[[2018,8]]}}}