{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,25]],"date-time":"2026-10-25T02:11:22Z","timestamp":1792894282340,"version":"4.5.0"},"reference-count":28,"publisher":"Scientific Scholar","issue":"6","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2016,12]]},"abstract":"\n Background & objectives:<\/jats:title>\n The process of human placentation is complex and still not well understood. This study was aimed to examine the relationship between clinical features of pre-eclampsia and degree of trophoblastic invasion after its immunohistochemical visualization in the context of possible alterations in the number of natural killer (NK) cells and macrophages in the decidua.<\/jats:p>\n <\/jats:sec>\n \n Methods:<\/jats:title>\n This prospective study included a study group comprising 30 pregnant women with pre-eclampsia delivered by caesarean section and a control group comprising 20 healthy pregnant women also delivered by caesarean section. Samples of placental bed obtained during caesarean section were analyzed after immunohistochemical labelling CD56+<\/jats:sup> NK cells, CD68+<\/jats:sup> macrophages and cytokeratin 7 trophoblastic cells.<\/jats:p>\n <\/jats:sec>\n \n Results:<\/jats:title>\n In pre-eclampsia, there was a significantly lower number of CD56+<\/jats:sup> NK cells in the decidua (P<\/jats:italic><0.001) and a higher number of CD68+<\/jats:sup> macrophages (P<\/jats:italic><0.001) compared to control group. In the subgroup of pre-eclampsia with intrauterine growth retardation (IUGR), a significantly greater number of NK cells (P<\/jats:italic><0.05) was recorded, as well as an increased number of macrophages, but not significantly compared to pre-eclampsia without IUGR. There was no significant difference in the distribution of these cells in the decidua in relation to the severity of pre-eclampsia. CD56+<\/jats:sup> NK cells were significantly less (P<\/jats:italic><0.05) and macrophages were more (P<\/jats:italic><0.05) in the group with poor trophoblastic invasion.<\/jats:p>\n <\/jats:sec>\n \n Interpretation & conclusions:<\/jats:title>\n Alterations in the number of immune cells in relation to the degree of trophoblastic invasion indicated their role in aetiopathogenesis of pre-eclampsia, while the direct association between their number and severity of pre-eclampsia was not confirmed.<\/jats:p>\n <\/jats:sec>","DOI":"10.4103\/ijmr.ijmr_776_15","type":"journal-article","created":{"date-parts":[[2017,4,28]],"date-time":"2017-04-28T13:56:29Z","timestamp":1493387789000},"page":"823-830","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":46,"title":["Number of decidual natural killer cells & macrophages in 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