{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,22]],"date-time":"2026-01-22T20:08:08Z","timestamp":1769112488262,"version":"3.49.0"},"reference-count":17,"publisher":"Scientific Scholar","issue":"6","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2019,12]]},"abstract":"\n Background & objectives:<\/jats:title>\n The burden of cardiovascular diseases is high in Kerala, India, and a considerable proportion of these occur in young people. The objective of this study was to estimate the severity of atherosclerosis in autopsies done for accidental and suicidal deaths in victims below 40 yr of age.<\/jats:p>\n <\/jats:sec>\n \n Methods:<\/jats:title>\n Coronary arteries from 77 autopsies done for unnatural deaths in a population below 40 yr were graded, and the degree of stenosis, intimal thickness index (ITI) and the intima-media ratio (IMR) were measured.<\/jats:p>\n <\/jats:sec>\n \n Results:<\/jats:title>\n There were 65 males and 12 females in the sample. The American Heart Association (AHA) type 3-6 (pathological intimal thickening) was seen in 55.4 per cent [95% confidence interval (CI): 42.5-67.7%] of males and 25 per cent (95% CI: 5.5-57.2%) of females and advanced lesions (type 4-6) in 44.6 per cent (95% CI: 32.3-57.5%) of males and 8.3 per cent (95% CI: 0.2-38.5%) of females. Types 5 or 6 lesions were seen in 32.2 per cent (95% CI: 21.2-45.1%) of males. The mean stenosis was 57.3 per cent in males and 40.6 per cent in females. More than 40 per cent stenosis was seen in 76.6 per cent cases, more than 50 per cent in 54.5 per cent cases and more than 75 per cent stenosis in 14.3 per of the sample. The mean ITI (MIT) was 1.85 and the mean IMR was 4.11. The degree of stenosis, MIT and IMR were significantly associated with male sex, overweight and smoking.<\/jats:p>\n <\/jats:sec>\n \n Interpretation & conclusions:<\/jats:title>\n Morphometric data showed that the degree of atherosclerotic narrowing of coronary arteries in young non-diseased population was high. It portends a danger to the community unless preventive measures are taken up.<\/jats:p>\n <\/jats:sec>","DOI":"10.4103\/ijmr.ijmr_811_17","type":"journal-article","created":{"date-parts":[[2020,1,30]],"date-time":"2020-01-30T13:32:15Z","timestamp":1580391135000},"page":"592-597","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":6,"title":["Autopsy-based morphometric study of coronary atherosclerosis in young adults"],"prefix":"10.25259","volume":"150","author":[{"given":"R.","family":"Thiripurasundari","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K.","family":"Sreekumari","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K.P.","family":"Aravindan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"10894","reference":[{"key":"R1-10-20241212","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1186\/s12872-016-0189-3","article-title":"Prevalence of coronary artery disease and its risk factors in Kerala, South India: A community-based cross-sectional study","volume":"16","author":"Krishnan","year":"2016","journal-title":"BMC Cardiovasc Disord"},{"key":"R2-10-20241212","doi-asserted-by":"crossref","first-page":"896","DOI":"10.1177\/1010539510365100","article-title":"All-cause mortality and cardiovascular mortality in Kerala state of India: Results from a 5-year follow-up of 161,942 rural community dwelling adults","volume":"23","author":"Soman","year":"2011","journal-title":"Asia Pac J Public Health"},{"key":"R3-10-20241212","first-page":"93","article-title":"Acute myocardial infarction in North Kerala \u2013 A 20 year hospital based study","volume":"43","author":"Mammi","year":"1991","journal-title":"Indian Heart J"},{"key":"R4-10-20241212","doi-asserted-by":"crossref","first-page":"1355","DOI":"10.1161\/01.CIR.92.5.1355","article-title":"A definition of advanced types of atherosclerotic lesions and a histological classification of atherosclerosis. 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An autopsy study of the aorta and the coronary, cerebral, renal, and pulmonary arteries","volume":"24","author":"Mathur","year":"1961","journal-title":"Circulation"},{"key":"R9-10-20241212","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1007\/s12055-010-0057-1","article-title":"Prevalence of atherosclerosis in coronary artery and internal thoracic artery and its correlation in North\u2013West Indians","volume":"26","author":"Puri","year":"2010","journal-title":"Indian J Thorac Cardiovasc Surg"},{"key":"R10-10-20241212","first-page":"265","article-title":"Coronary atherosclerosis in Mangalore \u2013 A random post mortem study","volume":"44","author":"Singh","year":"2001","journal-title":"Indian J Pathol Microbiol"},{"key":"R11-10-20241212","first-page":"236","article-title":"Atherosclerosis in coronaries in Malwa region","volume":"27","author":"Singh","year":"2005","journal-title":"J Indian Assoc Forensic Med"},{"key":"R12-10-20241212","first-page":"972","article-title":"Coronary artery atherosclerosis revisited in Korean war combat casualties","volume":"111","author":"Virmani","year":"1987","journal-title":"Arch Pathol Lab Med"},{"key":"R13-10-20241212","doi-asserted-by":"crossref","first-page":"1185","DOI":"10.1001\/jama.1971.03180330061012","article-title":"Coronary artery disease in combat casualties in Vietnam","volume":"216","author":"McNamara","year":"1971","journal-title":"JAMA"},{"key":"R14-10-20241212","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1016\/0735-1097(93)90050-B","article-title":"Manifestations of coronary atherosclerosis in young trauma victims \u2013 An autopsy study","volume":"22","author":"Joseph","year":"1993","journal-title":"J Am Coll Cardiol"},{"key":"R15-10-20241212","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1161\/01.CIR.102.4.374","article-title":"Association of Coronary Heart Disease Risk Factors with microscopic qualities of coronary atherosclerosis in youth","volume":"102","author":"McGill","year":"2000","journal-title":"Circulation"},{"key":"R16-10-20241212","first-page":"972","article-title":"Coronary artery atherosclerosis revisited in Korean war combat casualties","volume":"111","author":"Virmani","year":"1987","journal-title":"Arch Pathol Lab Med"},{"key":"R17-10-20241212","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1136\/bmj.327.7415.591","article-title":"Preclinical coronary atherosclerosis in a population with low incidence of myocardial infarction: Cross sectional autopsy study","volume":"327","author":"Bertomeu","year":"2003","journal-title":"BMJ"}],"container-title":["Indian Journal of Medical Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.lww.com\/10.4103\/ijmr.IJMR_811_17","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,7,2]],"date-time":"2025-07-02T23:02:58Z","timestamp":1751497378000},"score":1,"resource":{"primary":{"URL":"https:\/\/ijmr.org.in\/autopsy-based-morphometric-study-of-coronary-atherosclerosis-in-young-adults\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,12]]},"references-count":17,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2019]]}},"URL":"https:\/\/doi.org\/10.4103\/ijmr.ijmr_811_17","relation":{},"ISSN":["0971-5916"],"issn-type":[{"value":"0971-5916","type":"print"}],"subject":[],"published":{"date-parts":[[2019,12]]}}}