{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T16:18:54Z","timestamp":1787761134266,"version":"build-2784847793"},"reference-count":60,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"4","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2022,10]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Pregnant women who live in tuberculosis (TB)-affected households are more likely to develop latent TB infection (LTBI), which often escapes treatment. This study aims to determine if Interferon-gamma release (IGRA) is reliable in screening for LTBI in pregnant women, compare to the tuberculin skin test (TST).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>It was a cross-sectional study that involved 60 pregnant women with TB contact history as a proxy for LTBI and 30 pregnant women without contact history<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>.<\/jats:title>\n                    <jats:p>Latent TB was detected using the TST 5 tuberculin units and IGRA using the QuantiFERON Gold Plus TB Test kit (QFT-Plus). The sensitivity and specificity of the two diagnostic methods and the agreement between them were estimated using SPSS version 20.0.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      The sensitivity 95% (95% confidence interval [CI]: 86.08%\u201398.96%) and specificity 26.7% (95% CI: 12.28%\u201345.89%) of TST were compared to that of the IGRA with 60% (95% CI: 46.54%\u201372.44%) and 73.3% (95% CI: 54.11%\u201387.72%) sensitivity and specificity, respectively in detecting LTBI in pregnancy. Although there was a significant difference (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; 0.05) between TST and IGRA, the agreement was fair (kappa 0.39; 95% CI: 0.24\u20130.45).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>TST assay is more sensitive than IGRA; however, the specificity of IGRA was superior to the TST method. In this study, a fair agreement of TST and IGRA was observed for detecting latent TB infection in pregnant women with household contact with TB patients.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/ijmy.ijmy_112_22","type":"journal-article","created":{"date-parts":[[2022,12,10]],"date-time":"2022-12-10T05:30:33Z","timestamp":1670650233000},"page":"364-370","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":6,"title":["Tuberculin Test versus Interferon Gamma Release Assay in Pregnant Women with Household Contacts of Tuberculosis Patients"],"prefix":"10.4103","volume":"11","author":[{"given":"Maisuri Tadjuddin","family":"Chalid","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dian","family":"Puspawaty","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andi Mardiah","family":"Tahir","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hidayah","family":"Najdah","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muhammad Nasrum","family":"Massi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R2-4-20240902","doi-asserted-by":"crossref","first-page":"S629","DOI":"10.1093\/infdis\/jix362","article-title":"What we know about tuberculosis transmission: An overview","volume":"216","author":"Churchyard","year":"2017","journal-title":"J Infect Dis"},{"key":"R3-4-20240902","doi-asserted-by":"crossref","first-page":"1367","DOI":"10.1093\/infdis\/jiu625","article-title":"Cough and the transmission of tuberculosis","volume":"211","author":"Turner","year":"2015","journal-title":"J Infect Dis"},{"key":"R4-4-20240902","doi-asserted-by":"crossref","first-page":"v1000","DOI":"10.12688\/f1000research.13224.1","article-title":"Early clearance versus control: What is the meaning of a negative tuberculin skin test or interferon-gamma release assay following exposure to Mycobacterium tuberculosis?","volume":"7","author":"Meermeier","year":"2018","journal-title":"F1000Res"},{"key":"R6-4-20240902","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1016\/j.ijid.2014.12.014","article-title":"Perspectives on tuberculosis in pregnancy","volume":"32","author":"Bates","year":"2015","journal-title":"Int J Infect Dis"},{"key":"R7-4-20240902","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1111\/imr.12274","article-title":"T cells and adaptive immunity to Mycobacterium tuberculosis in humans","volume":"264","author":"Jasenosky","year":"2015","journal-title":"Immunol Rev"},{"key":"R8-4-20240902","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1111\/j.1471-0528.2010.02771.x","article-title":"Tuberculosis in pregnancy","volume":"118","author":"Mnyani","year":"2011","journal-title":"BJOG"},{"key":"R9-4-20240902","doi-asserted-by":"crossref","first-page":"1532","DOI":"10.1093\/cid\/cis732","article-title":"Tuberculosis in pregnant and postpartum women: Epidemiology, management, and research gaps","volume":"55","author":"Mathad","year":"2012","journal-title":"Clin Infect Dis"},{"key":"R10-4-20240902","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1111\/j.1471-0528.2010.02504.x","article-title":"Increased risk of low birthweight and small for gestational age infants among women with tuberculosis","volume":"117","author":"Lin","year":"2010","journal-title":"BJOG"},{"key":"R11-4-20240902","doi-asserted-by":"crossref","first-page":"845","DOI":"10.1164\/rccm.201310-1846OC","article-title":"Timing of tuberculosis transmission and the impact of household contact tracing. 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