{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T16:52:19Z","timestamp":1791305539700,"version":"4.3.1"},"reference-count":21,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"3","license":[{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Improving the effectiveness of pulmonary tuberculosis (TB) treatment is one of the main objectives of the healthcare system in Russia. The aim of this study was to search for a relationship between the composition of long-chain fatty acids and aldehydes detected in bronchial lavage samples from patients with TB and the features of the TB infection during the treatment.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>\n                      This study included 262 patients with pulmonary TB with varying treatment durations and different drug sensitivity profiles of the pathogen. Patients\u2019 samples were collected during routine bronchoscopy using the minilavage technique. Each sample was examined for\n                      <jats:italic toggle=\"yes\">Mycobacterium tuberculosis<\/jats:italic>\n                      by standard laboratory methods and for long-chain fatty acids and aldehydes by gas chromatography\u2013mass spectrometry analysis.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      We found that a higher proportion of aldehydes (18:1d9a, 18:1d11a, and i17:0a) and monounsaturated fatty acids (20:1d9 and 20:1d11) in bronchial lavage samples was associated with worse treatment outcomes (presence of bacterial shedding and cavities at the time of sampling and 6 months later), as well as with smoking and the\n                      <jats:italic toggle=\"yes\">M. tuberculosis<\/jats:italic>\n                      Beijing genotype. In contrast, favorable treatment outcomes were associated with an increased proportion of saturated fatty acids, including branchedchain fatty acids (i16:0, a17:0, 17:0, a15:0, and i15:0).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>The identified marker profile may have prognostic value and warrants further prospective validation.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/ijmy.ijmy_136_26","type":"journal-article","created":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T03:00:09Z","timestamp":1790823609000},"page":"261-271","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":0,"title":["The Proportion of Long-chain Fatty Aldehydes and Acids in Bronchial Lavage as a Marker of Treatment Outcomes in Pulmonary Tuberculosis"],"prefix":"10.4103","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8014-1230","authenticated-orcid":false,"given":"Tatiana","family":"Umpeleva","sequence":"first","affiliation":[{"name":"Scientific Department of Microbiology and Preclinical Research, National Medical Research Center of Phthisiopulmonology and Infectious Diseases, Ministry of Health of Russia, Ekaterinburg, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Tsvirenko","sequence":"additional","affiliation":[{"name":"Scientific Department of Clinical Research, National Medical Research Center of Phthisiopulmonology and Infectious Diseases, Ministry of Health of Russia, Ekaterinburg, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elena","family":"Kildyusheva","sequence":"additional","affiliation":[{"name":"Scientific Department of Clinical Research, National Medical Research Center of Phthisiopulmonology and Infectious Diseases, Ministry of Health of Russia, Ekaterinburg, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sergey","family":"Skornyakov","sequence":"additional","affiliation":[{"name":"Scientific Department of Clinical Research, National Medical Research Center of Phthisiopulmonology and Infectious Diseases, Ministry of Health of Russia, Ekaterinburg, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diana","family":"Vakhrusheva","sequence":"additional","affiliation":[{"name":"Scientific Department of Microbiology and Preclinical Research, National Medical Research Center of Phthisiopulmonology and Infectious Diseases, Ministry of Health of Russia, Ekaterinburg, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2026,9,30]]},"reference":[{"key":"R2-20261006","doi-asserted-by":"crossref","first-page":"260","DOI":"10.4103\/ijmy.ijmy_132_21","article-title":"Microbiome in sputum as a potential biomarker of chronicity in pulmonary resistant to rifampicin-tuberculosis and multidrug-resistant-tuberculosis patients","volume":"10","author":"Wiqoyah","year":"2021","journal-title":"Int J Mycobacteriol"},{"key":"R3-20261006","doi-asserted-by":"crossref","first-page":"63","DOI":"10.3920\/BM2010.0017","article-title":"Study of human microecology by mass spectrometry of microbial markers","volume":"2","author":"Osipov","year":"2011","journal-title":"Benef Microbes"},{"key":"R4-20261006","doi-asserted-by":"crossref","first-page":"90","DOI":"10.58838\/2075-1230-2024-102-6-90-97","article-title":"Specific microbiota of the lower respiratory tract in patients with various forms of pulmonary tuberculosis according to microbial marker testing data","volume":"102","author":"Umpeleva","year":"2024","journal-title":"Tuberc Lung Dis"},{"key":"R5-20261006","doi-asserted-by":"crossref","first-page":"506","DOI":"10.36488\/cmac.2025.4.506-515","article-title":"Comparison of microbial profiles of sputum and bronchial washings of patients with pulmonary tuberculosis according to PCR data","volume":"27","author":"Umpeleva","year":"2025","journal-title":"Clin Microbiol Antimicrob Chemother"},{"key":"R7-20261006","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1186\/s40168-018-0492-6","article-title":"Saturated long-chain fatty acid-producing bacteria contribute to enhanced colonic motility in rats","volume":"6","author":"Zhao","year":"2018","journal-title":"Microbiome"},{"key":"R8-20261006","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1079\/BJN20041080","article-title":"Estimated intake of milk fat is negatively associated with cardiovascular risk factors and does not increase the risk of a first acute myocardial infarction. 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