{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T17:24:25Z","timestamp":1787765065882,"version":"build-2784847793"},"reference-count":26,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"3","license":[{"start":{"date-parts":[[2023,7,1]],"date-time":"2023-07-01T00:00:00Z","timestamp":1688169600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-sa\/4.0"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2023,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>The purpose of this meta-analysis is to verify that rs1861494 and rs2069718, two polymorphisms in the IFN-gene, are associated with tuberculosis (TB) infection in Asian populations.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>To find appropriate case\u2013control studies, a search was done from the databases, including Google Scholar, Science Direct, Embase, and PubMed. With the aid of MetaGenyo software, statistical analyses were performed. Case and control studies from the available database were used to investigate the relationship between IFN-\u03b3 gene polymorphisms and TB infection risk. The protocol for the present meta-analysis was registered using PROSPERO (ID Number: 443605).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      Information obtained through examining two different variants of the IFN-\u03b3 gene showed associations with recessive, allelic, overdominant, and dominant models. This indicates that the statistical value obtained was found to be statistically significant at\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.05. The findings of the IFN-\u03b3 rs1861494 gene polymorphisms for allelic, dominant, and overdominant models were statistically significant with\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &gt; 0.05, whereas the recessive model exhibited a statistically insignificant value (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.25). The IFN-\u03b3 rs2069718 gene polymorphism demonstrated statistically significant value for overdominant, recessive, and allelic models (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &gt; 0.05). However, the dominant model shows a statistically insignificant value\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.11.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>The two genetic variations of the IFN-\u03b3 gene polymorphisms (rs1861494 and rs2069718) and their association with TB were confirmed by the meta-analysis conducted. More in-depth research into the molecular basis of the association is necessary, and larger-scale epidemiological studies are needed to confirm these findings.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/ijmy.ijmy_138_23","type":"journal-article","created":{"date-parts":[[2025,3,5]],"date-time":"2025-03-05T02:00:21Z","timestamp":1741140021000},"page":"226-234","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":2,"title":["IFN-gene Polymorphisms as a Risk Factor for Tuberculosis Infection in Asian Populations: A Meta-analysis"],"prefix":"10.4103","volume":"12","author":[{"given":"Bibin Savio","family":"Antony","sequence":"first","affiliation":[{"name":"Department of Biotechnology, Faculty of Allied Health Science, Chettinad Hospital and Research Institute, Chettinad Academy of Research and Education, Kelambakkam, Tamil Nadu, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chitra","family":"Nagarajan","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Sri Venkateswara Dental College and Hospital, Chennai, Tamil Nadu, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kanakam Elizabeth","family":"Thomas","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Asan Memorial Dental College and Hospital, Chengalpattu, Tamil Nadu, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sharon Benita","family":"Stephen","sequence":"additional","affiliation":[{"name":"Department of Biotechnology, Faculty of Allied Health Science, Chettinad Hospital and Research Institute, Chettinad Academy of Research and Education, Kelambakkam, Tamil Nadu, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Santhosh Kumar","family":"Yasam","sequence":"additional","affiliation":[{"name":"Department of Biotechnology, Faculty of Allied Health Science, Chettinad Hospital and Research Institute, Chettinad Academy of Research and Education, Kelambakkam, Tamil Nadu, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0531-424X","authenticated-orcid":false,"given":"Gowtham Kumar","family":"Subbaraj","sequence":"additional","affiliation":[{"name":"Department of Biotechnology, Faculty of Allied Health Science, Chettinad Hospital and Research Institute, Chettinad Academy of Research and Education, Kelambakkam, Tamil Nadu, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2023,9,15]]},"reference":[{"key":"R1-20250306","article-title":"Disease Control Priorities in Developing Countries. 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