{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T00:17:06Z","timestamp":1790900226012,"version":"4.1.0"},"reference-count":25,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"4","license":[{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2025,10]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>\n                      Tuberculosis (TB) is an infectious disease caused by\n                      <jats:italic toggle=\"yes\">Mycobacterium tuberculosis<\/jats:italic>\n                      , one of which involves miR-146a-5p as a specific microRNA molecule that is expressed exclusively on immune cells to modulate innate immunity. This study aims to examine and compare the expression of miR-146a-5p in active and latent TB patients. This study utilized a descriptive-analytic and cross-sectional design.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>We used real-time quantitative polymerase chain reaction method to examine the strength of miR-146a-5p expression. Statistical analysis involved employing descriptive statistics to summarize the sample characteristics. One-way analysis of variance was utilized to conduct inferential analysis, evaluating the differences in miR-146a-5p expression across various groups. The odds ratio calculation was employed to assess the strength of association, whereas the receiver-operating characteristic curve analysis was performed to examine the diagnostic potential.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>The results showed that men dominated the incidence of active TB compared to women with a prevalence of 83% and 17%, respectively. While in latent TB, women dominated compared to men (78% and 22%). The results of the examination of miR-146a-5pexpression in active TB samples were up regulation with a value of 24,86535, whereas in latent TB samples were down regulation with a value of 0,22727. Active TB and latent TB samples showed a significant comparison in terms of miR-146a-5p expression.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>Based on the research we have done, miR-146a-5p can be used as a biomarker in TB infection.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/ijmy.ijmy_189_25","type":"journal-article","created":{"date-parts":[[2025,12,18]],"date-time":"2025-12-18T20:00:14Z","timestamp":1766088014000},"page":"382-389","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":1,"title":["Diagnostic Potential of miR-146a-5p in Differentiating Active and Latent Tuberculosis Infections: A Cross-sectional Study"],"prefix":"10.4103","volume":"14","author":[{"given":"Ovi","family":"Rusmariza","sequence":"first","affiliation":[{"name":"Department of Microbiology, Faculty of Medicine, Hasanuddin University, Palu, Central Sulawesi, Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3347-6529","authenticated-orcid":false,"given":"Muhammad Nasrum","family":"Massi","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Faculty of Medicine, Hasanuddin University, Palu, Central Sulawesi, Indonesia"},{"name":"Hasanuddin University Medical Research Center, Faculty of Medicine, Hasanuddin University, Palu, Central Sulawesi, Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rizalinda","family":"Sjahril","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Faculty of Medicine, Hasanuddin University, Palu, Central Sulawesi, Indonesia"},{"name":"Hasanuddin University Medical Research Center, Faculty of Medicine, Hasanuddin University, Palu, Central Sulawesi, Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"family":"Handayani","sequence":"additional","affiliation":[{"name":"Hasanuddin University Medical Research Center, Faculty of Medicine, Hasanuddin University, Palu, Central Sulawesi, Indonesia"},{"name":"Department of Medical Technology Laboratory, Megarezky University, Palu, Central Sulawesi, Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zainul","family":"Muttaqin","sequence":"additional","affiliation":[{"name":"Hasanuddin University Medical Research Center, Faculty of Medicine, Hasanuddin University, Palu, Central Sulawesi, Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Baedah","family":"Madjid","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Faculty of Medicine, Hasanuddin University, Palu, Central Sulawesi, Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoeke Dewi","family":"Rasita","sequence":"additional","affiliation":[{"name":"Center for Health Laboratory Makassar, Makassar, South Sulawesi, Palu, Central Sulawesi, Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"family":"Nadyah","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Faculty of Medicine, Hasanuddin University, Palu, Central Sulawesi, Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andi Meutiah","family":"Ilhamjaya","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Faculty of Medicine, Alkhairaat University, Palu, Central Sulawesi, Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2025,12,18]]},"reference":[{"key":"R1-20260420","doi-asserted-by":"crossref","first-page":"153","DOI":"10.4103\/ijmy.ijmy_54_25","article-title":"Potential role of whole genome sequencing to predict the virulence, anti-TB resistance, and 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