{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,4]],"date-time":"2026-11-04T22:27:02Z","timestamp":1793831222197,"version":"4.6.1"},"reference-count":10,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"4","license":[{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2025,10]]},"abstract":"<jats:p>\n                    Interferon-\u03b3 serves as the pivotal cytokine for macrophage activation. Anti-interferon-\u03b3 autoantibody (AIGA)-mediated adult-onset immunodeficiency (AOID) represents a phenocopy of primary immunodeficiency, characterized by recurrent disseminated infections predominantly caused by\n                    <jats:italic toggle=\"yes\">Mycobacterium abscessus<\/jats:italic>\n                    complex (MABC) and other nontuberculous mycobacteria. Disseminated MABC (dMABC) in AOID poses significant therapeutic challenges, requiring long-term multidrug antimicrobial therapy combined with AIGA-targeted immunotherapy. This report details three cases of AOID with dMABC. All patients exhibited recurrent fevers, widespread cutaneous erythema, nodules, pustules, and painful multifocal lymphadenopathy over several months to 2 years. Serum AIGA testing was positive in all cases. MABC was isolated from skin and lymph node specimens through culture or next-generation sequencing. Radiologic studies confirmed systemic involvement, including pulmonary, lymphatic, and osteoarticular sites. A therapeutic regimen of combined antibiotics and low-to-medium-dose oral glucocorticoids (prednisone 20\u201330 mg\/day initiated, tapered to 5 mg\/day maintenance) was instituted, leading to clinical resolution in all patients. All were discharged successfully and remained disease-free on long-term follow-up.\n                  <\/jats:p>","DOI":"10.4103\/ijmy.ijmy_191_25","type":"journal-article","created":{"date-parts":[[2025,12,18]],"date-time":"2025-12-18T20:00:24Z","timestamp":1766088024000},"page":"407-411","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":4,"title":["Anti-interferon-\u03b3 Autoantibody-mediated Adult-onset Immunodeficiency with Disseminated Mycobacterium abscessus Complex Infection: A Report of Three Cases"],"prefix":"10.4103","volume":"14","author":[{"given":"Yonghao","family":"Deng","sequence":"first","affiliation":[{"name":"Department of Dermatology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong Province, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naiyu","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Dermatology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong Province, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiande","family":"Han","sequence":"additional","affiliation":[{"name":"Department of Dermatology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong Province, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4653-3489","authenticated-orcid":false,"given":"Rong","family":"Yin","sequence":"additional","affiliation":[{"name":"Department of Dermatology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong Province, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2025,12,18]]},"reference":[{"key":"R1-20260420","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1016\/j.jaci.2021.11.016","article-title":"Anticytokine autoantibodies: Autoimmunity trespassing on antimicrobial immunity","volume":"149","author":"Cheng","year":"2022","journal-title":"J Allergy Clin Immunol"},{"key":"R2-20260420","doi-asserted-by":"crossref","first-page":"349","DOI":"10.4103\/ijmy.ijmy_186_21","article-title":"The role of interferon-gamma and interferon-gamma receptor in tuberculosis and nontuberculous mycobacterial infections","volume":"10","author":"Ghanavi","year":"2021","journal-title":"Int J Mycobacteriol"},{"key":"R3-20260420","doi-asserted-by":"crossref","first-page":"1051673","DOI":"10.3389\/fimmu.2022.1051673","article-title":"Pathogen spectrum and immunotherapy in patients with anti-IFN-\u03b3 autoantibodies: A multicenter retrospective study and systematic review","volume":"13","author":"Qiu","year":"2022","journal-title":"Front Immunol"},{"key":"R4-20260420","doi-asserted-by":"crossref","first-page":"1239","DOI":"10.1093\/cid\/cix996","article-title":"Clinical significance of interferon-\u03b3 neutralizing autoantibodies against disseminated nontuberculous mycobacterial disease","volume":"66","author":"Aoki","year":"2018","journal-title":"Clin Infect Dis"},{"key":"R5-20260420","doi-asserted-by":"crossref","first-page":"217","DOI":"10.4103\/ijmy.ijmy_141_21","article-title":"Nontuberculous mycobacterium: An emerging pathogen: Indian perspective","volume":"10","author":"Rajendran","year":"2021","journal-title":"Int J Mycobacteriol"},{"key":"R6-20260420","doi-asserted-by":"crossref","first-page":"293","DOI":"10.4103\/ijmy.ijmy_110_21","article-title":"Skin and soft-tissue infections due to rapidly growing mycobacteria: An overview","volume":"10","author":"Kumar","year":"2021","journal-title":"Int J Mycobacteriol"},{"key":"R7-20260420","doi-asserted-by":"crossref","first-page":"e3927","DOI":"10.1097\/MD.0000000000003927","article-title":"Clinical manifestations, course, and outcome of patients with neutralizing anti-interferon-\u03b3 autoantibodies and disseminated nontuberculous mycobacterial infections","volume":"95","author":"Chi","year":"2016","journal-title":"Medicine (Baltimore)"},{"key":"R8-20260420","doi-asserted-by":"crossref","first-page":"211","DOI":"10.4103\/ijmy.ijmy_131_23","article-title":"The in vitro activity of carbapenems alone and in combination with \u03b2-lactamase inhibitors against difficult-to-treat mycobacteria; Mycobacterium tuberculosis, Mycobacterium abscessus, and Mycobacterium avium complex: A systematic review","volume":"12","author":"Andersson","year":"2023","journal-title":"Int J Mycobacteriol"},{"key":"R9-20260420","doi-asserted-by":"crossref","first-page":"e1","DOI":"10.1093\/cid\/ciaa241","article-title":"Treatment of nontuberculous mycobacterial pulmonary disease: An official ATS\/ERS\/ESCMID\/IDSA clinical practice guideline","volume":"71","author":"Daley","year":"2020","journal-title":"Clin Infect Dis"},{"key":"R10-20260420","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1111\/j.1365-2567.2007.02611.x","article-title":"Glucocorticoids exert opposing effects on macrophage function dependent on their concentration","volume":"122","author":"Lim","year":"2007","journal-title":"Immunology"}],"container-title":["The International Journal of Mycobacteriology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.4103\/ijmy.ijmy_191_25","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T18:52:07Z","timestamp":1786647127000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/ijmy.ijmy_191_25"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10]]},"references-count":10,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2025]]}},"URL":"https:\/\/doi.org\/10.4103\/ijmy.ijmy_191_25","relation":{},"ISSN":["2212-5531","2212-554X"],"issn-type":[{"value":"2212-5531","type":"print"},{"value":"2212-554X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,10]]},"assertion":[{"value":"2025-10-12","name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-10-28","name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}}]}}