{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T16:41:20Z","timestamp":1787071280988,"version":"build-2736575974"},"reference-count":15,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"4","license":[{"start":{"date-parts":[[2024,10,1]],"date-time":"2024-10-01T00:00:00Z","timestamp":1727740800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-sa\/4.0"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2024,10]]},"abstract":"<jats:p>\n                    Disseminated tuberculosis (dTB) is usually rare in immunocompetent individuals. We report a case of dTB presented with constitutional symptoms and extensive lymphadenopathy with bilateral lung parenchymal airspace opacities. Histopathological and molecular methods confirmed the etiological agent \u2013\n                    <jats:italic toggle=\"yes\">Mycobacterium tuberculosis<\/jats:italic>\n                    . She was started on first-line antitubercular treatment and she had significant clinical recovery.\n                  <\/jats:p>","DOI":"10.4103\/ijmy.ijmy_201_23","type":"journal-article","created":{"date-parts":[[2024,12,19]],"date-time":"2024-12-19T15:01:38Z","timestamp":1734620498000},"page":"457-460","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":1,"title":["A Century-Old Threat: Disseminated Tuberculosis in a Healthy Host \u2013 Case Report"],"prefix":"10.4103","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3146-541X","authenticated-orcid":false,"given":"Poongodi Santhana","family":"Kumarasamy","sequence":"first","affiliation":[{"name":"Department of Microbiology, Tirunelveli Medical College, Tirunelveli, Tamil Nadu, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bala","family":"Ponnuthurai","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine, Shifa Hospitals, Tirunelveli, Tamil Nadu, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stanley James Benjamin","family":"Swamidoss","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine, Shifa Hospitals, Tirunelveli, Tamil Nadu, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohamed Arafath","family":"Mohamed","sequence":"additional","affiliation":[{"name":"Department of General Medicine, Shifa Hospitals, Tirunelveli, Tamil Nadu, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2024,12,19]]},"reference":[{"key":"R2-20241219","first-page":"DC05","article-title":"Evaluation of truenat MTB\/RIF test in comparison with microscopy and culture for diagnosis of extrapulmonary tuberculosis in a tertiary care centre","volume":"15","author":"Jose","year":"2021","journal-title":"J Clin Diagn Res"},{"key":"R3-20241219","doi-asserted-by":"crossref","first-page":"e352","DOI":"10.1016\/S1473-3099(19)30162-8","article-title":"Severe disseminated tuberculosis in HIV-negative refugees","volume":"19","author":"Su\u00e1rez","year":"2019","journal-title":"Lancet Infect Dis"},{"key":"R4-20241219","doi-asserted-by":"crossref","first-page":"83","DOI":"10.4103\/jfcm.JFCM_106_18","article-title":"Review of literature on disseminated tuberculosis with emphasis on the focused diagnostic workup","volume":"26","author":"Khan","year":"2019","journal-title":"J Family Community Med"},{"key":"R5-20241219","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1186\/1757-1626-1-383","article-title":"Disseminated tuberculosis following the placement of ureteral stents: A case repot","volume":"1","author":"Salem","year":"2008","journal-title":"Cases J"},{"key":"R6-20241219","doi-asserted-by":"crossref","first-page":"162","DOI":"10.4103\/ijmy.ijmy_31_17","article-title":"Epidemiology of extrapulmonary and disseminated tuberculosis in a tertiary care center in Oman","volume":"6","author":"Gaifer","year":"2017","journal-title":"Int J Mycobacteriol"},{"key":"R7-20241219","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1016\/j.pulmoe.2018.11.001","article-title":"Predictors and outcomes of disseminated tuberculosis in an intermediate burden setting","volume":"25","author":"Meira","year":"2019","journal-title":"Pulmonology"},{"key":"R8-20241219","doi-asserted-by":"crossref","first-page":"30","DOI":"10.4103\/ijmy.ijmy_242_21","article-title":"Uncommon manifestations in tuberculosis: An expanding clinical spectrum from North India","volume":"11","author":"Singh","year":"2022","journal-title":"Int J Mycobacteriol"},{"key":"R9-20241219","doi-asserted-by":"crossref","first-page":"349","DOI":"10.4103\/ijmy.ijmy_186_21","article-title":"The role of interferon-gamma and interferon-gamma receptor in tuberculosis and nontuberculous mycobacterial infections","volume":"10","author":"Ghanavi","year":"2021","journal-title":"Int J Mycobacteriol"},{"key":"R10-20241219","doi-asserted-by":"crossref","first-page":"443","DOI":"10.4103\/lungindia.lungindia_165_22","article-title":"Diagnostic yield of CBNAAT in the diagnosis of extrapulmonary tuberculosis: A prospective observational study","volume":"39","author":"Nishal","year":"2022","journal-title":"Lung India"},{"key":"R11-20241219","doi-asserted-by":"crossref","first-page":"107","DOI":"10.4103\/ijmy.ijmy_207_19","article-title":"An evidence-based clinical pathway for the diagnosis of tuberculous lymphadenitis: A systematic review","volume":"9","author":"Sivaratnam","year":"2020","journal-title":"Int J Mycobacteriol"},{"key":"R12-20241219","doi-asserted-by":"crossref","first-page":"212","DOI":"10.4103\/ijmy.ijmy_99_18","article-title":"Cervical tuberculous lymphadenitis: Clinical profile and diagnostic modalities","volume":"7","author":"Gautam","year":"2018","journal-title":"Int J Mycobacteriol"},{"key":"R13-20241219","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2016\/8132741","article-title":"A histomorphological pattern analysis of pulmonary tuberculosis in lung autopsy and surgically resected specimens","volume":"2016","author":"Gupta","year":"2016","journal-title":"Patholog Res Int"},{"key":"R14-20241219","doi-asserted-by":"crossref","first-page":"e1094","DOI":"10.1097\/MD.0000000000001094","article-title":"Diagnostic usefulness of IFN-gamma releasing assays compared with conventional tests in patients with disseminated tuberculosis","volume":"94","author":"Yu","year":"2015","journal-title":"Medicine (Baltimore)"},{"key":"R15-20241219","doi-asserted-by":"crossref","first-page":"10931","DOI":"10.1038\/s41598-017-09895-7","article-title":"Disseminated tuberculosis among hospitalised HIV patients in South Africa: A common condition that can be rapidly diagnosed using urine-based assays","volume":"7","author":"Kerkhoff","year":"2017","journal-title":"Sci Rep"},{"key":"R16-20241219","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/j.jctube.2017.12.002","article-title":"Usage of cartridge based nucleic acid amplification test (CB-NAAT\/GeneXpert) test as diagnostic modality for pediatric tuberculosis; case series from Mangalore, South India","volume":"11","author":"Sahana","year":"2018","journal-title":"J Clin Tuberc Other Mycobact Dis"}],"container-title":["The International Journal of Mycobacteriology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.4103\/ijmy.ijmy_201_23","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T15:44:04Z","timestamp":1787067844000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/ijmy.ijmy_201_23"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,10]]},"references-count":15,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2024]]}},"URL":"https:\/\/doi.org\/10.4103\/ijmy.ijmy_201_23","relation":{},"ISSN":["2212-5531","2212-554X"],"issn-type":[{"value":"2212-5531","type":"print"},{"value":"2212-554X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,10]]},"assertion":[{"value":"2024-09-02","name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-11-27","name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}}]}}