{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T19:33:11Z","timestamp":1786649591824,"version":"build-2736575974"},"reference-count":38,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"2","license":[{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-sa\/4.0"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2025,4]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Studies on the role of mannose-binding lectin 2 (MBL2) in individuals infected with tuberculosis (TB) remain limited. This study aimed to compare MBL2 gene expression and protein concentration between active and latent TB cases and to assess the influence of sex on these differences.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>This cross-sectional study involved 39 newly diagnosed active pulmonary TB patients and 25 individuals with latent TB who were household contacts. MBL2 gene expression was evaluated using a relative quantitative polymerase chain reaction method. MBL protein levels were measured using the enzyme-linked immunosorbent assay.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      Among female participants, MBL2 gene expression was significantly lower in those with active TB compared to those with latent TB (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.02). In male participants, no significant difference was observed (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.333). Similarly, MBL protein levels tended to be lower in females with active TB than in those with latent TB, though this difference was not statistically significant (median [range]: 124.78 [65.62\u2013499.79] vs. 208.49 [99.85\u2013498.65] ng\/mL,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.099). In males, no significant difference in MBL protein levels was detected between the active TB and latent TB groups (206.86 [59.11\u2013526.77] vs. 143.55 [65.85\u2013290.7] ng\/mL,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.285).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>This study highlights the influence of sex on the expression of the MBL2 gene and plasma protein levels in TB patients. A lower expression of the MBL2 gene in active TB cases compared to latent TB cases was observed exclusively in women.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/ijmy.ijmy_229_24","type":"journal-article","created":{"date-parts":[[2025,6,20]],"date-time":"2025-06-20T15:00:15Z","timestamp":1750431615000},"page":"96-102","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":1,"title":["The Effect of Sex on Active and Latent Tuberculosis Occurrence Based on Mannose-Binding Lectin 2 Gene Expression and Mannose-binding Lectin Plasma Concentration in Indonesia"],"prefix":"10.4103","volume":"14","author":[{"given":"Yanti","family":"Leman","sequence":"first","affiliation":[{"name":"Department of Pharmacology, Faculty of Medicine, Universitas Hasanuddin, Makassar, Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3347-6529","authenticated-orcid":false,"given":"Muhammad Nasrum","family":"Massi","sequence":"additional","affiliation":[{"name":"Department of Clinical Microbiology, Faculty of Medicine, Universitas Hasanuddin, Makassar, Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Kabo","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Faculty of Medicine, Universitas Hasanuddin, Makassar, Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahyar","family":"Ahmad","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Faculty of Mathematics and Natural Science, Universitas Hasanuddin, Makassar, Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nur Ahmad","family":"Tabri","sequence":"additional","affiliation":[{"name":"Department of Pulmonology, Faculty of Medicine, Universitas Hasanuddin, Makassar, Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Agussalim","family":"Bukhari","sequence":"additional","affiliation":[{"name":"Department of Clinical Nutrition, Faculty of Medicine, Universitas Hasanuddin, Makassar, Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siti","family":"Rafiah","sequence":"additional","affiliation":[{"name":"Department of Anatomy, Faculty of Medicine, Universitas Hasanuddin, Makassar, Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irawaty","family":"Djaharuddin","sequence":"additional","affiliation":[{"name":"Department of Pulmonology, Faculty of Medicine, Universitas Hasanuddin, Makassar, Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rahmawati","family":"Minhajat","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Faculty of Medicine, Universitas Hasanuddin, Makassar, Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ilhamjaya","family":"Patellongi","sequence":"additional","affiliation":[{"name":"Department of Physiology, Faculty of Medicine, Universitas Hasanuddin, Makassar, Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ni Nyoman Sri","family":"Budayanti","sequence":"additional","affiliation":[{"name":"Department of Clinical Microbiology, Faculty of Medicine, Universitas Udayana, Denpasar, Bali, Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Najdah","family":"Hidayah","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences, Graduate School of Universitas Hasanuddin, Makassar, Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irda","family":"Handayani","sequence":"additional","affiliation":[{"name":"Department of Clinical Pathology, Faculty of Medicine, Universitas Hasanuddin, Makassar, 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