{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T19:17:46Z","timestamp":1787771866583,"version":"build-2784847793"},"reference-count":23,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020]]},"abstract":"\n Background:<\/jats:title>\n \n Treatment of\n Mycobacterium abscessus<\/jats:italic>\n pulmonary disease (PD) is challenging with frequent side effects and uncertain rates of success.\n <\/jats:p>\n <\/jats:sec>\n \n Methods:<\/jats:title>\n \n We performed a retrospective review of all patients at our center with at least one respiratory sample positive for\n M. abscessus<\/jats:italic>\n between 2014 and 2019. Electronic health records were reviewed to determine factors associated with\n M. abscessus<\/jats:italic>\n infection and clinical outcomes.\n <\/jats:p>\n <\/jats:sec>\n \n Results:<\/jats:title>\n \n Thirty-seven patients were identified including 24 with cystic fibrosis (CF), 10 with bronchiectasis, two with chronic obstructive PD (COPD), and one with asthma. American Thoracic Society\/Infectious Diseases Society of America criteria for nontuberculous mycobacteria PD were met in 21\/37 (56.8%) of cases. Evidence of\n Aspergillus<\/jats:italic>\n lung disease was noted in 18 (75.0%) CF patients compared with 3 (23.1%) non-CF patients (\n P<\/jats:italic>\n = 0.005). Induction therapy for\n M. abscessus<\/jats:italic>\n was given to 22\/37 (59.5%) patients (18\/24 [75%] with CF and 4\/13 [30.8%] without CF). Median duration of induction therapy was 6 weeks (range 3\u201312). Maintenance antibiotic therapy was prescribed to 17\/22 (77.3%) of treated patients. Culture conversion was seen in 15\/24 (62.5%) of CF patients compared with 3\/13 (23.1%) in the non-CF group (\n P<\/jats:italic>\n = 0.034). Culture conversion occurred in 10\/22 (45.5%) of treated patients compared with 8\/15 (53.3%) untreated patients. Three patients (8.1%) died during follow-up: one with CF and two with COPD.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions:<\/jats:title>\n \n Culture conversion following isolation of\n M. abscessus<\/jats:italic>\n from respiratory samples not only is more common in CF than in patients without CF but also frequently occurs spontaneously in both groups. Targeted treatment for\n M. abscessus<\/jats:italic>\n did not clearly impact rates of culture conversion.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.4103\/ijmy.ijmy_3_20","type":"journal-article","created":{"date-parts":[[2024,2,12]],"date-time":"2024-02-12T09:00:54Z","timestamp":1707728454000},"page":"48-52","source":"Crossref","is-referenced-by-count":12,"title":["Outcomes of Pulmonary Mycobacterium abscessus Infection"],"prefix":"10.4103","volume":"9","author":[{"given":"William G.","family":"Flight","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natasha E.","family":"Hough","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen 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2010-2014","volume":"15","author":"Adjemian","year":"2018","journal-title":"Ann Am Thorac Soc"},{"key":"R6-9-20240212","doi-asserted-by":"crossref","first-page":"896","DOI":"10.1164\/rccm.200905-0704OC","article-title":"Antibiotic treatment of Mycobacterium abscessus lung disease: A retrospective analysis of 65 patients","volume":"180","author":"Jeon","year":"2009","journal-title":"Am J Respir Crit Care Med"},{"key":"R7-9-20240212","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1164\/rccm.201003-0395OC","article-title":"Clinical significance of differentiation of Mycobacterium massiliense from Mycobacterium abscessus","volume":"183","author":"Koh","year":"2011","journal-title":"Am J Respir Crit Care Med"},{"key":"R8-9-20240212","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1093\/cid\/ciq237","article-title":"Clinical and microbiologic outcomes in patients receiving treatment for Mycobacterium abscessus pulmonary disease","volume":"52","author":"Jarand","year":"2011","journal-title":"Clin Infect Dis"},{"key":"R9-9-20240212","doi-asserted-by":"crossref","first-page":"i1","DOI":"10.1136\/thoraxjnl-2015-207360","article-title":"US Cystic Fibrosis Foundation and European Cystic Fibrosis Society consensus recommendations for the management of non-tuberculous mycobacteria in individuals with cystic fibrosis","volume":"71","author":"Floto","year":"2016","journal-title":"Thorax"},{"key":"R10-9-20240212","doi-asserted-by":"crossref","first-page":"ii1","DOI":"10.1136\/thoraxjnl-2017-210927","article-title":"British Thoracic Society guidelines for the management of non-tuberculous mycobacterial pulmonary disease (NTM-PD)","volume":"72","author":"Haworth","year":"2017","journal-title":"Thorax"},{"key":"R11-9-20240212","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1164\/rccm.200604-571ST","article-title":"An official ATS\/IDSA statement: Diagnosis, treatment, and prevention of nontuberculous 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Mycobacteriol"},{"key":"R15-9-20240212","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1016\/j.jcf.2017.04.013","article-title":"Outcomes associated with antibiotic regimens for treatment of Mycobacterium abscessus in cystic fibrosis patients","volume":"16","author":"DaCosta","year":"2017","journal-title":"J Cyst Fibros"},{"key":"R16-9-20240212","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1016\/j.jcf.2012.06.009","article-title":"Mycobacterium avium and Mycobacterium abscessus complex target distinct cystic fibrosis patient subpopulations","volume":"12","author":"Catherinot","year":"2013","journal-title":"J Cyst Fibros"},{"key":"R17-9-20240212","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/j.jcf.2009.12.001","article-title":"Chronic Mycobacterium abscessus infection and lung function decline in cystic fibrosis","volume":"9","author":"Esther","year":"2010","journal-title":"J Cyst 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