{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T16:34:44Z","timestamp":1787070884072,"version":"build-2736575974"},"reference-count":16,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"2","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2024,4]]},"abstract":"\n Background:<\/jats:title>\n \n Mycobacterium welchii<\/jats:italic>\n (\n Mycobacterium w<\/jats:italic>\n ) vaccine was one of the many strategies used to both treat and prevent coronavirus disease 2019 (COVID-19) infection. We report the results of a retrospective analysis of 15 cases with vaccine-site granulomas after administration of prophylactic\n Mycobacterium w<\/jats:italic>\n vaccine as part of a trial for COVID-19 and our experience in managing those cases.\n <\/jats:p>\n <\/jats:sec>\n \n Methods:<\/jats:title>\n This was a retrospective analysis of 15 patients with vaccine-site granulomas who were given the vaccine as a prophylactic measure as part of a trial with informed consent.<\/jats:p>\n <\/jats:sec>\n \n Results:<\/jats:title>\n The mean average age of cases was 37 and the male-to-female ratio was 1:0.87. All of the patients developed erythematous tender nodules over the injection sites within a month of receiving the inoculations. Mycobacterial cultures and cartridge-based nucleic acid amplification tests yielded negative results. Skin biopsy revealed granulomatous dermatitis with acid-fast bacilli positivity. A diagnosis of noninfective granulomatous dermatitis was made. Treatment started with analgesics and anti-inflammatory agents. Systemic antibiotics were required in 9\/15 patients. Patients are being followed up with no reported recurrence till date.<\/jats:p>\n <\/jats:sec>\n \n Conclusion:<\/jats:title>\n \n The possibility of injection-site granuloma should be taken into the risk\u2013benefit analysis for the administration of\n Mycobacterium w<\/jats:italic>\n vaccine and the patients should be counseled as such. Patients with persistent ulceration respond to combinations of doxycycline, ofloxacin, and clarithromycin.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.4103\/ijmy.ijmy_50_24","type":"journal-article","created":{"date-parts":[[2024,6,18]],"date-time":"2024-06-18T15:00:09Z","timestamp":1718722809000},"page":"178-182","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":0,"title":["Mycobacterium welchii Vaccine Granuloma \u2013 A Cautionary Tale"],"prefix":"10.4103","volume":"13","author":[{"given":"C Anju","family":"George","sequence":"first","affiliation":[{"name":"Department of Dermatology, Aster Medcity, Kochi, Kerala, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8771-6858","authenticated-orcid":false,"given":"Satyaki","family":"Ganguly","sequence":"additional","affiliation":[{"name":"Department of Dermatology, All India Institute of Medical Sciences, Raipur, Chhattisgarh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ajoy Kumar","family":"Behera","sequence":"additional","affiliation":[{"name":"Department of Pulmonary Medicine, All India Institute of Medical Sciences, Raipur, Chhattisgarh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T G","family":"Ranganath","sequence":"additional","affiliation":[{"name":"Department of Pulmonary Medicine, All India Institute of Medical Sciences, Raipur, Chhattisgarh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Soumil","family":"Khare","sequence":"additional","affiliation":[{"name":"Department of Dermatology, All India Institute of Medical Sciences, Raipur, Chhattisgarh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2024,6,15]]},"reference":[{"key":"R1-20240902","doi-asserted-by":"crossref","first-page":"355","DOI":"10.4103\/ijdvl.IJDVL_549_18","article-title":"A double-blind, 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