{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T12:44:25Z","timestamp":1789562665971,"version":"build-2803163510"},"reference-count":6,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"2","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2022,4]]},"abstract":"<jats:sec>\n                    <jats:title\/>\n                    <jats:p>Weil's syndrome, a severe form of the disease, may present with symptoms such as jaundice, renal dysfunction, and hemorrhagic diathesis and it can progress to multi-organ failure leading to death. In patients with coinfection of tuberculosis with leptospirosis, there may be severe hepatic and renal dysfunction rendering the standard antitubercular therapy (ATT) regimen useless, thus requiring alternate drug selection and dose modification of antitubercular drugs. We present a case of a 57-year-old female who presented with high-grade fever and yellowish discoloration of the eyes. She was diagnosed with Weil's disease and started on treatment. She later developed altered sensorium and lumbar puncture was suggestive of tubercular meningitis. Due to her deranged renal and hepatic function tests, she was started on a modified regimen of ATT with intermittent dialysis. The patient responded to treatment and was shifted to the standard Isoniazid, Rifampicin, Pyrazinamide, Ethambutol (HRZE) regimen once renal and hepatic functions returned to normal.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/ijmy.ijmy_56_22","type":"journal-article","created":{"date-parts":[[2022,6,14]],"date-time":"2022-06-14T06:10:54Z","timestamp":1655187054000},"page":"205-207","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":1,"title":["Tubercular Meningitis Complicated by Weil'S Syndrome \u2013 Management of Tuberculosis in a Patient with Concurrent Hepatic and Renal Dysfunction"],"prefix":"10.4103","volume":"11","author":[{"given":"Chaudhary Niraliben","family":"Hareshkumar","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Prashant","family":"Gopal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pradnya Mukund","family":"Diggikar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R2-12-20240902","doi-asserted-by":"crossref","first-page":"475","DOI":"10.4103\/ijmy.ijmy_175_21","article-title":"Colonic tuberculosis masquerading as Crohn's disease","volume":"10","author":"Kaur","year":"2021","journal-title":"Int J Mycobacteriol"},{"key":"R3-12-20240902","doi-asserted-by":"crossref","first-page":"327","DOI":"10.4103\/ijmy.ijmy_89_21","article-title":"Tuberculosis presenting as metastatic lung cancer","volume":"10","author":"Saleemi","year":"2021","journal-title":"Int J Mycobacteriol"},{"key":"R4-12-20240902","doi-asserted-by":"crossref","first-page":"438","DOI":"10.4103\/ijmy.ijmy_133_20","article-title":"A rare co-occurrence of optochiasmatic tuberculoma and guillain-barre syndrome as a paradoxical reaction in tubercular meningitis","volume":"9","author":"Bhowmick","year":"2020","journal-title":"Int J Mycobacteriol"},{"key":"R6-12-20240902","doi-asserted-by":"crossref","first-page":"149","DOI":"10.4103\/ijmy.ijmy_19_17","article-title":"Cholecalciferol for prophylaxis against antituberculosis therapy-induced liver disorders among na\u00efve patients with pulmonary tuberculosis: A randomized, comparative study","volume":"6","author":"Hasanain","year":"2017","journal-title":"Int J Mycobacteriol"},{"key":"R7-12-20240902","doi-asserted-by":"crossref","first-page":"281","DOI":"10.4103\/ijmy.ijmy_75_20","article-title":"Adverse drug reactions of anti-tuberculosis treatment among children with tuberculosis","volume":"9","author":"Laghari","year":"2020","journal-title":"Int J Mycobacteriol"},{"key":"R8-12-20240902","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1016\/j.jceh.2012.07.007","article-title":"A guide to the management of tuberculosis in patients with chronic liver disease","volume":"2","author":"Dhiman","year":"2012","journal-title":"J Clin Exp Hepatol"}],"container-title":["The International Journal of Mycobacteriology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.4103\/ijmy.ijmy_56_22","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T15:00:29Z","timestamp":1787756429000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/ijmy.ijmy_56_22"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,4]]},"references-count":6,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2022]]}},"URL":"https:\/\/doi.org\/10.4103\/ijmy.ijmy_56_22","relation":{},"ISSN":["2212-5531"],"issn-type":[{"value":"2212-5531","type":"print"}],"subject":[],"published":{"date-parts":[[2022,4]]}}}