{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T15:33:40Z","timestamp":1787758420047,"version":"build-2784847793"},"reference-count":35,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"3","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2022,7]]},"abstract":"\n Background:<\/jats:title>\n \n The immunology characteristics of the rat model of tuberculosis (TB) infection are still unclear. This study aimed to evaluate the dynamics of pathology and cytokines in a rat model infected with\n Mycobacterium<\/jats:italic>\n TB (MTB).\n <\/jats:p>\n <\/jats:sec>\n \n Methods:<\/jats:title>\n Sixty male Wistar rats were divided into four groups, namely the control group (without MTB infection) and the MTB -induced group (observations at week-3, week-6, and week-12 postinfection). Granuloma formation was analyzed by histology procedure. Analysis of the levels of tumor necrosis factor-a (TNF-\u03b1), interleukin-6 (IL-6), IL-17, IL-2, IL-4, and IL-12 was performed using an enzyme-linked immunosorbent assay technique.<\/jats:p>\n <\/jats:sec>\n \n Results:<\/jats:title>\n \n The number and size of the ganulomas increased proportionally between weeks 6 and 12 postinfection. Several cytokines, namely IL-6, IL-17, IL-2, IL-4, and IL-12 significantly increased in the 6\n th<\/jats:sup>\n week compared to the 3\n rd<\/jats:sup>\n week after infection (\n P<\/jats:italic>\n < 0.05). These cytokines decreased significantly at the 12\n th<\/jats:sup>\n week compared to the 6\n th<\/jats:sup>\n week (\n P<\/jats:italic>\n < 0.05). TNF-\u03b1 was found to be stable at the third and 6\n th<\/jats:sup>\n weeks and then decreased at the twelfth postinfection week. For IL-12, the longer the infection time, the higher the level.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions:<\/jats:title>\n It was concluded that there was a typical pattern of TB infection in Wistar rats, namely certain cytokines that peaked at week 6 of infection. Thus, TB infection in rats can be a model for early-phase TB study.<\/jats:p>\n <\/jats:sec>","DOI":"10.4103\/ijmy.ijmy_84_22","type":"journal-article","created":{"date-parts":[[2022,9,12]],"date-time":"2022-09-12T02:59:47Z","timestamp":1662951587000},"page":"299-302","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":0,"title":["Cytokines Dynamics in a Wistar Rat Model Infected with Mycobacterium Tuberculosis Strain 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