{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,3]],"date-time":"2026-11-03T18:12:45Z","timestamp":1793729565868,"version":"4.6.1"},"reference-count":9,"publisher":"Scientific Scholar","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:p>A 21-year-old euthyroid gentleman born to nonconsanguineous parents was diagnosed with bipolar affective disorder. He presented 4 years later with hypokalemic quadriparesis. On evaluation, he was found to have features of both proximal and distal renal tubular acidosis. Ophthalmologic examination by slit lamp confirmed the presence of the Kayser\u2013Fleischer ring. The diagnosis of Wilson\u2019s disease was established with serum ceruloplasmin levels and 24-h urinary copper levels.Here is a rare clinical presentation of Wilson\u2019s disease in the form of hypokalemic muscle paralysis due to proximal renal tubular acidosis with distal tubule involvement. The diagnosis was delayed due to the initial presentation with psychiatric symptoms.<\/jats:p>","DOI":"10.4103\/ijn.ijn_143_22","type":"journal-article","created":{"date-parts":[[2022,11,21]],"date-time":"2022-11-21T16:04:06Z","timestamp":1669046646000},"source":"Crossref","is-referenced-by-count":2,"title":["Wilson\u2019s Disease Presents as Recurrent Hypokalemic Muscle Paralysis"],"prefix":"10.25259","author":[{"given":"Mythri","family":"Shankar","sequence":"first","affiliation":[{"name":"Assistant Professor, Department of Nephrology, Institute of Nephro-urology, Bengaluru, Karnataka, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monica","family":"Nayaka","sequence":"additional","affiliation":[{"name":"Senior Resident, Department of Nephrology, Institute of Nephro-Urology, Bengaluru, Karnataka, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kishan","family":"Aralapuram","sequence":"additional","affiliation":[{"name":"Associate Professor, Department of Nephrology, Institute of Nephro-urology, Bengaluru, Karnataka, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sreedhara C.","family":"Gurusiddaiah","sequence":"additional","affiliation":[{"name":"Head of the Department, Department of Nephrology, Institute of Nephro-urology, Bengaluru, Karnataka, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"10894","published-online":{"date-parts":[[2022,11,22]]},"reference":[{"key":"R1-20231027","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1016\/S0140-6736(07)60196-2","article-title":"Wilson's disease","volume":"369","author":"Ala","year":"2007","journal-title":"Lancet"},{"key":"R2-20231027","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1023\/B:UROL.0000034630.73124.36","article-title":"Rare presentation of Wilson's disease:A case report","volume":"36","author":"Kalra","year":"2004","journal-title":"Int Urol Nephrol"},{"key":"R3-20231027","doi-asserted-by":"crossref","first-page":"bcr0420114121","DOI":"10.1136\/bcr.04.2011.4121","article-title":"Renal tubular acidosis due to Wilson's disease presenting as metabolic bone disease","volume":"2011","author":"Palkar","year":"2011","journal-title":"BMJ Case Rep"},{"key":"R4-20231027","first-page":"36","article-title":"Recurrent limb weakness as initial presentation of Wilson's disease","volume":"26","author":"Chakraborty","year":"2007","journal-title":"Indian J Gastroenterol"},{"key":"R5-20231027","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1136\/gut.2005.087262","article-title":"Clinical presentation, diagnosis and long-term outcome of Wilson's disease:A cohort study","volume":"56","author":"Merle","year":"2007","journal-title":"Gut"},{"key":"R6-20231027","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1186\/1757-1626-1-256","article-title":"Hypokalemic periodic paralysis:A case report and review of the literature","volume":"1","author":"Soule","year":"2008","journal-title":"Cases J"},{"key":"R7-20231027","first-page":"525","article-title":"Review of the diagnostic evaluation of renal tubular acidosis","volume":"16","author":"Yaxley","year":"2016","journal-title":"Ochsner J"},{"key":"R8-20231027","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1159\/000189114","article-title":"Recurrent hypokalemic muscle weakness as an initial manifestation of Wilson's disease","volume":"73","author":"Chu","year":"1996","journal-title":"Nephron"},{"key":"R9-20231027","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1177\/0009922809332684","article-title":"Recurrent limb weakness in a 17-year-old boy","volume":"48","author":"Thapa","year":"2009","journal-title":"Clin Pediatr (Phila)"}],"container-title":["Indian Journal of Nephrology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.lww.com\/10.4103\/ijn.ijn_143_22","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,4,3]],"date-time":"2024-04-03T19:43:48Z","timestamp":1712173428000},"score":1,"resource":{"primary":{"URL":"https:\/\/indianjnephrol.org\/wilsons-disease-presents-as-recurrent-hypokalemic-muscle-paralysis\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,11,22]]},"references-count":9,"URL":"https:\/\/doi.org\/10.4103\/ijn.ijn_143_22","relation":{},"ISSN":["0971-4065","1998-3662"],"issn-type":[{"value":"0971-4065","type":"print"},{"value":"1998-3662","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,11,22]]}}}