{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,25]],"date-time":"2026-06-25T01:52:58Z","timestamp":1782352378671,"version":"3.54.5"},"reference-count":39,"publisher":"Scientific Scholar","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023]]},"abstract":"<jats:title>Abstract<\/jats:title>\n          <jats:sec>\n            <jats:title>Introduction:<\/jats:title>\n            <jats:p>Idiopathic membranous nephropathy (iMN) is a rare cause of nephrotic syndrome in children (1%\u20137%). Anti-phospholipase A2 receptor (PLA<jats:sub>2<\/jats:sub>R) antibody positivity in kidney biopsy is observed in 52%\u201378% of adults and 45% of children with iMN. The objectives of the study are to analyze the clinical profile and outcome of membranous nephropathy in children, to assess the prevalence of anti-PLA<jats:sub>2<\/jats:sub>R immunohistochemistry (IHC) in kidney biopsy, and to correlate their presence with disease characteristics.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods:<\/jats:title>\n            <jats:p>We are reporting a single-center retrospective study conducted in pediatric nephrology division. Clinical data and outcome parameters of children with membranous nephropathy were analyzed. PLA<jats:sub>2<\/jats:sub>R IHC was performed in kidney biopsy specimens retrospectively.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results:<\/jats:title>\n            <jats:p>We analyzed 43 children with membranous nephropathy (MN) from a single center. 18 (42%) had idiopathic MN (iMN). PLA<jats:sub>2<\/jats:sub>R IHC was performed in kidney biopsy specimens in 14\/18 (78%) patients with iMN and 7\/9 (78%) non-lupus secondary membranous nephropathy (SMN) patients. The most common cause of SMN was lupus nephritis in 16 patients (64%). The mean estimated glomerular filtration rate (eGFR) at onset was 156 \u00b1 81 ml\/min\/1.73m<jats:sup>2<\/jats:sup>. The sensitivity and specificity of PLA<jats:sub>2<\/jats:sub>R IHC in diagnosing pediatric MN was 50% and 57%, respectively; positive and negative predictive values were 70% and 36%, respectively. At the final follow-up, chronic kidney disease stage 5 (CKD 5) developed in 2\/14 (14.3%) iMN patients.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusions:<\/jats:title>\n            <jats:p>IHC PLA<jats:sub>2<\/jats:sub>R staining of glomerular tissue is a useful diagnostic marker of IMN. Though PLA<jats:sub>2<\/jats:sub>R prevalence is lower in children, its role in guiding treatment needs further exploration.<\/jats:p>\n          <\/jats:sec>","DOI":"10.4103\/ijn.ijn_228_22","type":"journal-article","created":{"date-parts":[[2023,5,7]],"date-time":"2023-05-07T06:00:09Z","timestamp":1683439209000},"page":"432-439","source":"Crossref","is-referenced-by-count":2,"title":["The Clinical Profile and Long-Term Outcome of Children with Membranous Nephropathy, and the Evaluation of Anti-Phospholipase A2 Receptor Antibody Immunohistochemistry in Kidney Biopsy"],"prefix":"10.25259","volume":"33","author":[{"given":"RV","family":"Deepthi","sequence":"first","affiliation":[{"name":"Departments of Child Health, Division of Pediatric Nephrology, Christian Medical College, Vellore, Tamil Nadu, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sachin","family":"George","sequence":"additional","affiliation":[{"name":"Departments of Child Health, Division of Pediatric Nephrology, Christian Medical College, Vellore, Tamil Nadu, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Georgie","family":"Mathew","sequence":"additional","affiliation":[{"name":"Departments of Child Health, Division of Pediatric Nephrology, Christian Medical College, Vellore, Tamil Nadu, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sanjeet","family":"Roy","sequence":"additional","affiliation":[{"name":"Department of General Pathology, Division of Renal Pathology, Christian Medical College, Vellore, Tamil Nadu, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mandeep","family":"Bindra","sequence":"additional","affiliation":[{"name":"Consultant in Pathology, Naruvi Hospital, Vellore, Tamil Nadu, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Grace","family":"Rebekah","sequence":"additional","affiliation":[{"name":"Department of Biostatistics, Christian Medical College, Vellore, 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