{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,10]],"date-time":"2026-11-10T15:35:09Z","timestamp":1794324909594,"version":"4.9.0"},"reference-count":13,"publisher":"Scientific Scholar","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:title>Abstract<\/jats:title>\n          <jats:sec>\n            <jats:title>Introduction:<\/jats:title>\n            <jats:p>The most common complication of percutaneous kidney biopsy is bleeding, which can be seen in up to one-third of cases. The aim of this study was to evaluate the effect of prebiopsy administration of intranasal desmopressin acetate in reducing the incidence of biopsy-related bleeding complications.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods:<\/jats:title>\n            <jats:p>This was a prospective randomized double-blind pilot study conducted at our center from January 2021 to September 2022. Consecutive adult patients who underwent native percutaneous kidney biopsy with an estimated glomerular filtration rate (eGFR) \u226445 ml\/min\/1.73 m<jats:sup>2<\/jats:sup> were randomized into a placebo (saline intranasal spray) group versus intranasal desmopressin group. The bleeding complications were compared between the two groups.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results:<\/jats:title>\n            <jats:p>A total of 80 patients who underwent kidney biopsy at our center from January 2021 to September 2022 with eGFR \u226445 ml\/min\/1.73 m<jats:sup>2<\/jats:sup> were included (40 patients in desmopressin group and 40 patients in non-desmopressin group) in the study. The mean age of the patients was 44 \u00b1 12 years with a mean eGFR of 20.82 \u00b1 12.64 ml\/min\/1.73 m<jats:sup>2<\/jats:sup>. Intranasal desmopressin administration before kidney biopsy was associated with a significantly higher number of minor bleeding complications (<jats:italic toggle=\"yes\">P<\/jats:italic> = 0.02) and no significant reduction in major complications (<jats:italic toggle=\"yes\">P<\/jats:italic> = 0.15) when compared with a group that did not receive desmopressin. Other complications like hypotension, flushing, and vasovagal syncope were not statistically significantly associated with the use of desmopressin.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusions:<\/jats:title>\n            <jats:p>Our study did not find any utility of prophylactic desmopressin use before kidney biopsy in patients with kidney dysfunction.<\/jats:p>\n          <\/jats:sec>","DOI":"10.4103\/ijn.ijn_34_23","type":"journal-article","created":{"date-parts":[[2023,10,6]],"date-time":"2023-10-06T19:03:26Z","timestamp":1696619006000},"source":"Crossref","is-referenced-by-count":7,"title":["Role of Desmopressin Acetate before Percutaneous Ultrasound-Guided Kidney Biopsy in Patients with Kidney Dysfunction"],"prefix":"10.25259","author":[{"given":"Jasmine","family":"Sethi","sequence":"first","affiliation":[{"name":"Department of Nephrology, Post Graduate Institute of Medical Education and Research, Chandigarh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandeep","family":"Bansal","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Post Graduate Institute of Medical Education and Research, Chandigarh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anupam","family":"Lal","sequence":"additional","affiliation":[{"name":"Department of Radiodiagnosis, Post Graduate Institute of Medical Education and Research, Chandigarh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harbir Singh","family":"Kohli","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Post Graduate Institute of Medical Education and Research, Chandigarh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manish","family":"Rathi","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Post Graduate Institute of Medical Education and Research, Chandigarh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"10894","published-online":{"date-parts":[[2023,9,29]]},"reference":[{"key":"R1-20231006","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1053\/j.ajkd.2012.02.330","article-title":"Bleeding complications of native kidney biopsy:A systematic review and meta-analysis","volume":"60","author":"Corapi","year":"2012","journal-title":"Am J Kidney Dis"},{"key":"R2-20231006","doi-asserted-by":"crossref","first-page":"1969","DOI":"10.1007\/s11255-013-0560-6","article-title":"Factors that can minimize bleeding complications after renal biopsy","volume":"46","author":"Zhu","year":"2014","journal-title":"Int Urol Nephrol"},{"key":"R3-20231006","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1056\/NEJM198301063080102","article-title":"Deamino-8-D-arginine vasopressin shortens the bleeding time in uremia","volume":"308","author":"Mannucci","year":"1983","journal-title":"N Engl J Med"},{"key":"R4-20231006","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1136\/pgmj.2006.052118","article-title":"How do you treat bleeding disorders with desmopressin?","volume":"83","author":"Ozgonenel","year":"2007","journal-title":"Postgrad Med J"},{"key":"R5-20231006","doi-asserted-by":"crossref","first-page":"850","DOI":"10.1053\/j.ajkd.2010.12.019","article-title":"Desmopressin acetate in percutaneous ultrasound-guided kidney biopsy:A randomized controlled trial","volume":"57","author":"Manno","year":"2011","journal-title":"Am J Kidney Dis"},{"key":"R6-20231006","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1111\/nep.13004","article-title":"Desmopressin (Octostim\u00ae) before a native kidney biopsy can reduce the risk for biopsy complications in patients with impaired renal function:A pilot study","volume":"23","author":"Peters","year":"2018","journal-title":"Nephrology (Carlton)"},{"key":"R7-20231006","doi-asserted-by":"crossref","first-page":"1063","DOI":"10.1093\/ckj\/sfz114","article-title":"Intranasal desmopressin reduces renal biopsy-related bleeding and serum sodium levels in patients with reduced renal function","volume":"13","author":"Rao","year":"2019","journal-title":"Clin Kidney J"},{"key":"R8-20231006","doi-asserted-by":"crossref","first-page":"1205","DOI":"10.1111\/nep.13662","article-title":"KHA-CARI guideline recommendations for renal biopsy","volume":"24","author":"MacGinley","year":"2019","journal-title":"Nephrology (Carlton)"},{"key":"R9-20231006","doi-asserted-by":"crossref","first-page":"1180","DOI":"10.1016\/j.ekir.2020.05.006","article-title":"Use of desmopressin prior to kidney biopsy in patients with high bleeding risk","volume":"5","author":"Leclerc","year":"2020","journal-title":"Kidney Int Rep"},{"key":"R10-20231006","doi-asserted-by":"crossref","first-page":"430","DOI":"10.4103\/ijn.IJN_553_20","article-title":"Desmopressin acetate before percutaneous ultrasound-guided kidney biopsy in patients with renal failure - Is it really beneficial?","volume":"32","author":"Jose","year":"2022","journal-title":"Indian J Nephrol"},{"key":"R11-20231006","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.nefroe.2020.12.008","article-title":"No effect of desmopressin administration before kidney biopsy on the risk of major post-biopsy bleeding","volume":"42","author":"Cheong","year":"2022","journal-title":"Nefrologia (Engl Ed)"},{"key":"R12-20231006","doi-asserted-by":"crossref","first-page":"287","DOI":"10.5527\/wjn.v3.i4.287","article-title":"Renal biopsy practice:What is the gold standard?","volume":"3","author":"Brachemi","year":"2014","journal-title":"World J Nephrol"},{"key":"R13-20231006","doi-asserted-by":"crossref","first-page":"808","DOI":"10.1053\/j.ajkd.2011.02.375","article-title":"Percutaneous kidney biopsy: \u201cThe needle and the damage done\u201d?","volume":"57","author":"Whittier","year":"2011","journal-title":"Am J Kidney Dis"}],"container-title":["Indian Journal of Nephrology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.lww.com\/10.4103\/ijn.ijn_34_23","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,4,3]],"date-time":"2024-04-03T19:47:24Z","timestamp":1712173644000},"score":1,"resource":{"primary":{"URL":"https:\/\/indianjnephrol.org\/role-of-desmopressin-acetate-before-percutaneous-ultrasound-guided-kidney-biopsy-in-patients-with-kidney-dysfunction\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,9,29]]},"references-count":13,"URL":"https:\/\/doi.org\/10.4103\/ijn.ijn_34_23","relation":{},"ISSN":["0971-4065","1998-3662"],"issn-type":[{"value":"0971-4065","type":"print"},{"value":"1998-3662","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,9,29]]}}}