{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,25]],"date-time":"2026-05-25T08:05:38Z","timestamp":1779696338748,"version":"3.53.1"},"reference-count":22,"publisher":"Scientific Scholar","issue":"2","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2023,4]]},"abstract":"\n Aim\/Background:<\/jats:title>\n Sentinel lymph node biopsy (SLNB) has become the standard of care for nodal staging in early-stage oral squamous cell carcinoma (OSCC) as an alternative to elective neck dissection. However, the role of sentinel lymph node (SLN) and lymphatic drainage mapping with image-guided surgery has not been studied in locally advanced OSCC. Therefore, this study was undertaken to evaluate the role of lymphatic drainage mapping in the identification of contralateral cervical lymph node metastasis in locally advanced OSCC (Stage III-IVb).<\/jats:p>\n <\/jats:sec>\n \n Materials and Methods:<\/jats:title>\n \n We have prospectively analyzed treatment-na\u00efve patients of locally advanced, lateralized OSCC (\n n<\/jats:italic>\n = 20). All patients underwent SLN imaging using peritumoral injection 0.5\u20131.0 mCi of 99 mTc-Sulfur colloid (Filtered) and intraoperative identification of contralateral neck nodes using a handheld gamma probe (Crystal Photonics).\n <\/jats:p>\n <\/jats:sec>\n \n Results:<\/jats:title>\n A total of 20 patients (18 males and 2 females) with a median age of 52.5 (33\u201370 years) were included. Ipsilateral SLN was localized in 18 (90%) patients. Bilateral cervical nodes were visualized only in 7 (35%) patients on lymphoscintigraphy (LSG). Out of the seven patients, 5 patients underwent bilateral neck dissection and 2 patients had unilateral neck dissection with LSG-guided exploration of contralateral cervical node and intraoperative frozen section examination. Six out of these seven patients had one or other risk factor for contralateral metastasis (patients had either primary in the tongue, involvement of floor of mouth, or tumor thickness >3.75 mm). On postoperative HPE, only 1\/20 (5%) patient showed metastasis in the contralateral cervical lymph node.<\/jats:p>\n <\/jats:sec>\n \n Conclusion:<\/jats:title>\n Correct identification of metastatic disease in contralateral neck directly influences clinical management, as it can reduce contralateral neck failure rate and limit the morbidity associated with unnecessary contralateral neck dissection, and it is also crucial in radiotherapy planning in locally advanced OSCC. In the current study, lymphatic drainage mapping showed a metastatic rate of 5% in the contralateral neck nodes in locally advanced, lateralized OSCC. However, the role of SLNB and lymphatic drainage mapping in this subgroup of OSCC needs to be studied in larger population to validate these findings.<\/jats:p>\n <\/jats:sec>","DOI":"10.4103\/ijnm.ijnm_120_22","type":"journal-article","created":{"date-parts":[[2023,6,10]],"date-time":"2023-06-10T13:55:05Z","timestamp":1686405305000},"page":"125-133","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":6,"title":["Role of Sentinel Lymph Node Drainage Mapping for Localization of Contralateral Lymph Node Metastasis in Locally Advanced Oral Squamous Cell Carcinoma \u2013 A Prospective Pilot 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