{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,25]],"date-time":"2026-05-25T08:05:50Z","timestamp":1779696350530,"version":"3.53.1"},"reference-count":12,"publisher":"Scientific Scholar","issue":"1","license":[{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-sa\/4.0"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:sec>\n                    <jats:title>Purpose of the Study:<\/jats:title>\n                    <jats:p>This study evaluates the feasibility and diagnostic accuracy of Tc-99 m sulfur colloid as a tracer for sentinel lymph node (SLN) mapping in early-stage epithelial ovarian cancer (EOC) with the aim to explore SLN mapping as a less invasive alternative to traditional lymphadenectomy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods:<\/jats:title>\n                    <jats:p>This prospective observational study involved 10 patients with early-stage EOC or suspicious ovarian masses. Tc-99 m S colloid (37 mBq) was injected subperitoneally at infundibulopelvic and ovarian ligaments near the ovary, followed by SLN detection with a gamma probe. SLNs were analyzed using ultrastaging. Diagnostic accuracy metrics, including sensitivity, specificity, positive predictive value, and negative predictive value, were calculated.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>SLN detection was achieved in 100% of cases, with detection rates of 10% in the pelvic region and 30% in the para-aortic region alone and in both in 60%. The time for SLN detection was 14.2 \u00b1 4.89 min. Histopathology revealed isolated tumor cells in two cases, with no false negatives observed. Postoperative complications included surgical site infections, transfusions, and paralytic ileus, but no SLN-specific complications were reported.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>This study demonstrates the feasibility and diagnostic accuracy of SLN detection using technetium-99m sulfur colloid in early-stage ovarian cancer. The findings indicate a high detection rate, no false negatives, and the potential to reduce the need for systematic lymphadenectomy. Further research is required to validate these findings and evaluate their impact on long-term clinical outcomes.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/ijnm.ijnm_149_24","type":"journal-article","created":{"date-parts":[[2025,5,16]],"date-time":"2025-05-16T03:00:12Z","timestamp":1747364412000},"page":"16-21","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":2,"title":["Sentinel Lymph Node Detection in Early-stage Ovarian Cancer Using Radionuclide Technetium-99m Sulfur Colloid - A Feasibility Study"],"prefix":"10.25259","volume":"40","author":[{"given":"Ayush","family":"Heda","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynaecology (Gynaecologic Oncology), All India Institute of Medical Sciences, Rishikesh, Uttarakhand, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shalini","family":"Rajaram","sequence":"additional","affiliation":[{"name":"Department of 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