{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,25]],"date-time":"2026-05-25T08:05:01Z","timestamp":1779696301729,"version":"3.53.1"},"reference-count":30,"publisher":"Scientific Scholar","issue":"1","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2021,1]]},"abstract":"\n Purpose of the Study:<\/jats:title>\n Radioiodine (I-131) is used as an effective noninvasive treatment for thyroid malignancies. Salivary gland is one of the most affected nontarget organs. The present study aims to perform early quantification of salivary gland function after I-131 therapy (RIT) for thyroid cancer considering I-131 down-scatter in the Tc-99m window.<\/jats:p>\n <\/jats:sec>\n \n Materials and Methods:<\/jats:title>\n \n A total of 20 patients (6 males and 14 females) with differentiated thyroid carcinoma were enrolled in the study. Baseline dynamic salivary scintigraphy was performed in all patients using 185\u2013370 MBq (5\u201310 mCi) Tc-99m pertechnetate. Posttherapy, salivary scintigraphy was performed 10\u201325 days after RIT in the range of 1.85\u20137.4 GBq (50\u2013200 mCi). Time\u2013activity curves obtained from the pre- and posttherapy dynamic salivary scintigraphy were used for semi-quantitative analysis. Uptake ratio (UR), ejection fraction (EF%), and maximum accumulation (MA%) were calculated by drawing regions of interest of individual parotid and submandibular glands over a composite image, after correcting for down-scatter from I-131 in the Tc-99m window. A paired\n t<\/jats:italic>\n -test was used for comparison of the parameters obtained.\n <\/jats:p>\n <\/jats:sec>\n \n Results:<\/jats:title>\n \n Significant changes were observed in UR and EF% of both parotid and submandibular glands (\n P<\/jats:italic>\n < 0.05). No significant changes were found in the value of MA% of left parotid gland and both submandibular glands in the posttherapy scans in comparison to pretherapy scans (\n P<\/jats:italic>\n > 0.05). However, significant difference was observed in the MA% of the right parotid gland (\n P<\/jats:italic>\n = 0.025).\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion:<\/jats:title>\n Salivary gland function was found to deteriorate after RIT, with the parotid glands affected more than the submandibular glands.<\/jats:p>\n <\/jats:sec>","DOI":"10.4103\/ijnm.ijnm_158_20","type":"journal-article","created":{"date-parts":[[2021,3,4]],"date-time":"2021-03-04T04:31:38Z","timestamp":1614832298000},"page":"25-31","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":2,"title":["Early Quantification of Salivary Gland Function after Radioiodine Therapy"],"prefix":"10.25259","volume":"36","author":[{"given":"Karan Singh","family":"Tanwar","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nivedita","family":"Rana","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bhagwant Rai","family":"Mittal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anish","family":"Bhattacharya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"10894","reference":[{"key":"R1-5-20240902","first-page":"e1091","article-title":"The incidence and mortality of thyroid cancer and its relationship with HDI in the world","volume":"5","author":"Salehiniya","year":"2018","journal-title":"World J Cancer Res"},{"key":"R2-5-20240902","doi-asserted-by":"crossref","first-page":"103","DOI":"10.14310\/horm.2002.1260","article-title":"Increasing world incidence of thyroid cancer: Increased detection or higher radiation exposure?","volume":"9","author":"Wartofsky","year":"2010","journal-title":"Hormones (Athens"},{"key":"R3-5-20240902","doi-asserted-by":"crossref","first-page":"1767","DOI":"10.1002\/1097-0142(19871015)60:8<1767::AID-CNCR2820600816>3.0.CO;2-P","article-title":"New subgrouping of small thyroid carcinomas","volume":"60","author":"Kasai","year":"1987","journal-title":"Cancer"},{"key":"R4-5-20240902","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1056\/NEJM199801293380506","article-title":"Papillary and follicular thyroid carcinoma","volume":"338","author":"Schlumberger","year":"1998","journal-title":"N Engl J Med"},{"key":"R5-5-20240902","doi-asserted-by":"crossref","first-page":"2372","DOI":"10.1002\/1097-0142(19871115)60:10<2372::AID-CNCR2820601004>3.0.CO;2-1","article-title":"Treatment of locally advanced thyroid carcinoma with combination doxorubicin and radiation therapy","volume":"60","author":"Kim","year":"1987","journal-title":"Cancer"},{"key":"R6-5-20240902","first-page":"71","article-title":"TThe beginnings of radioiodine therapy of metastatic thyroid carcinoma: A memoir of Samuel M","volume":"14","author":"Siegel","year":"1999","journal-title":"(1895.1955) and his celebrated patient. 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