{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,25]],"date-time":"2026-05-25T08:05:40Z","timestamp":1779696340711,"version":"3.53.1"},"reference-count":11,"publisher":"Scientific Scholar","issue":"3","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2023,7]]},"abstract":"<jats:p>\n                    Malignant otitis externa (MOE) with skull base osteomyelitis (SBO) is an aggressive infection that predominantly affects elderly, diabetic, or immunocompromised patients, and is associated with high disease-specific mortality.\n                    <jats:italic toggle=\"yes\">Pseudomonas aeruginosa<\/jats:italic>\n                    is the most isolated microorganism. External otitis associated with granulation tissue and pain is the most common presenting feature; a biopsy is obtained to rule out malignancy. A proper consensus is lacking regarding the best imaging modality for early initial diagnosis and follow-up. 99mTechnetium (99mTc)-labeled ubiquicidin (UBI) 29\u201341 is a bacterial attaching peptide that does not bind to activated leukocytes. We report a case of SBO initially misdiagnosed as a chronic otitis media, but later proved to be a case of MOE. 99mTc methylene diphosphonate bone scan and 99mTc-UBI 29\u201341 scan with single-photon emission computed tomography\/computed tomography scans were performed to corroborate the clinical diagnosis. SBO remains a great challenge due to its increasing prevalence and high morbidity are difficult to diagnose and are often confused with cholesteatoma and neoplastic process. The UBI scan could be an auxiliary noninvasive diagnostic alternative in early diagnosis.\n                  <\/jats:p>","DOI":"10.4103\/ijnm.ijnm_192_22","type":"journal-article","created":{"date-parts":[[2023,10,13]],"date-time":"2023-10-13T03:00:47Z","timestamp":1697166047000},"page":"297-300","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":2,"title":["99mTechnetium-Ubiquicidin Scan with Single-Photon Emission Computed Tomography\/Computed Tomography in Skull Base Osteomyelitis"],"prefix":"10.25259","volume":"38","author":[{"given":"Arunraj","family":"Vatakara","sequence":"first","affiliation":[{"name":"Department of ENT, All India Institute of Medical Sciences, New Delhi, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nishikant Avinash","family":"Damle","sequence":"additional","affiliation":[{"name":"Department of ENT Nuclear Medicine, All India Institute of Medical Sciences, New Delhi, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aditi","family":"Khurana","sequence":"additional","affiliation":[{"name":"Department of ENT Nuclear Medicine, All India Institute of Medical Sciences, New Delhi, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sambit","family":"Sagar","sequence":"additional","affiliation":[{"name":"Department of ENT Nuclear Medicine, All India Institute of Medical Sciences, New Delhi, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rajeev","family":"Kumar","sequence":"additional","affiliation":[{"name":"Department of ENT, All India Institute of Medical Sciences, New Delhi, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hitesh","family":"Verma","sequence":"additional","affiliation":[{"name":"Department of ENT, All India Institute of Medical Sciences, New Delhi, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"10894","published-online":{"date-parts":[[2023,10,10]]},"reference":[{"key":"R1-20240902","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1016\/j.otc.2008.01.004","article-title":"Malignant otitis externa","volume":"41","author":"Carfrae","year":"2008","journal-title":"Otolaryngol Clin North Am"},{"key":"R2-20240902","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1007\/BF02598005","article-title":"Technetium bone scanning in the diagnosis of osteomyelitis: A meta-analysis of test performance. Diagnostic technology assessment consortium","volume":"7","author":"Littenberg","year":"1992","journal-title":"J Gen Intern Med"},{"key":"R3-20240902","doi-asserted-by":"crossref","first-page":"846","DOI":"10.1017\/S0022215110000691","article-title":"Malignant otitis externa: Case series","volume":"124","author":"Ali","year":"2010","journal-title":"J Laryngol Otol"},{"key":"R4-20240902","doi-asserted-by":"crossref","first-page":"623036","DOI":"10.1155\/2013\/623036","article-title":"The use of (18) F-FDG-PET\/CT for diagnosis and treatment monitoring of inflammatory and infectious diseases","volume":"2013","author":"Glaudemans","year":"2013","journal-title":"Clin Dev Immunol"},{"key":"R5-20240902","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1016\/S1470-2045(05)70208-4","article-title":"Tumours of the external ear and temporal bone","volume":"6","author":"Devaney","year":"2005","journal-title":"Lancet Oncol"},{"key":"R6-20240902","doi-asserted-by":"crossref","first-page":"961","DOI":"10.1002\/lary.27526","article-title":"FDG-PET\/CT for diagnosis and follow-up of necrotizing (malignant) external otitis","volume":"129","author":"Stern Shavit","year":"2019","journal-title":"Laryngoscope"},{"key":"R7-20240902","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1097\/00003072-200007000-00006","article-title":"Use of Tc-99m HMPAO leukocyte scans to evaluate bone infection: Incremental value of additional SPECT images","volume":"25","author":"Weon","year":"2000","journal-title":"Clin Nucl Med"},{"key":"R8-20240902","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1016\/S0969-8051(03)00054-4","article-title":"In vitro and in vivo assessment of 99mTc-UBI specificity for bacteria","volume":"30","author":"Ferro-Flores","year":"2003","journal-title":"Nucl Med Biol"},{"key":"R9-20240902","first-page":"27","article-title":"Application of the ubiquicidin 29-41 scan in the diagnosis of pyogenic vertebral osteomyelitis","volume":"25","author":"Dillmann-Arroyo","year":"2011","journal-title":"Acta Ortop Mex"},{"key":"R10-20240902","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1017\/S0022215100101562","article-title":"The diagnostic criteria of malignant external otitis","volume":"101","author":"Cohen","year":"1987","journal-title":"J Laryngol Otol"},{"key":"R12-20240902","doi-asserted-by":"crossref","first-page":"726","DOI":"10.1097\/MNM.0b013e32833a3d7f","article-title":"Clinical trial of specific imaging of infections","volume":"31","author":"Arteaga de Murphy","year":"2010","journal-title":"Nucl Med Commun"}],"container-title":["Indian Journal of Nuclear Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.lww.com\/10.4103\/ijnm.ijnm_192_22","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,25]],"date-time":"2026-05-25T07:37:56Z","timestamp":1779694676000},"score":1,"resource":{"primary":{"URL":"https:\/\/ijnm.co.in\/99mtechnetium-ubiquicidin-scan-with-single-photon-emission-computed-tomography-computed-tomography-in-skull-base-osteomyelitis\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,7]]},"references-count":11,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2023]]}},"URL":"https:\/\/doi.org\/10.4103\/ijnm.ijnm_192_22","relation":{},"ISSN":["0972-3919","0974-0244"],"issn-type":[{"value":"0972-3919","type":"print"},{"value":"0974-0244","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,7]]},"assertion":[{"value":"2022-12-05","name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-12-27","name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}}]}}