{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T23:54:38Z","timestamp":1790294078202,"version":"4.1.0"},"reference-count":16,"publisher":"Scientific Scholar","issue":"4","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2023,10]]},"abstract":"\n Purpose:<\/jats:title>\n Postconcurrent chemoradiotherapy (CRT) response assessment has been challenging in locally advanced head-and-neck squamous cell carcinoma (LA-HNSCC) due to prevailing postradiation changes. Molecular response methods have been encouraging, although further clarifications and validations were needed. We tested the effectiveness of a proposed semi-quantitative molecular response criterion in these patients.<\/jats:p>\n <\/jats:sec>\n \n Materials and Methods:<\/jats:title>\n \n Two subspecialty-trained physicians evaluated\n 18<\/jats:sup>\n F-fluorodeoxyglucose positron emission tomography\/computed tomography of LA-HNSCC patients (\n n<\/jats:italic>\n = 83) post 3 months CRT using a five points Head and Neck Molecular Imaging-Reporting and Data System (HAN-MI-RADS) criterion. Where available, histopathology examination with clinical and imaging interpretation was taken as a reference for the disease. A diagnostic accuracy comparison was done with the existing Hopkins score. Further effectiveness was analyzed with disease-free survival (DFI) and overall survival (OS).\n <\/jats:p>\n <\/jats:sec>\n \n Results:<\/jats:title>\n Metastasis was developed in 11\/83 patients at 3 months of evaluation. Of 72 patients, 39, 2, and 31 patients had a complete response, equivocal response, and partial response as per HAN-MI-RADS. Per patient sensitivity, specificity, positive predictive value, negative predictive value, and accuracy for predicting loco-regional disease up to 1 and 2 years was 93.3%, 92.5%, 90.3%, 94.9%, 92.9%, and 84.9%, 91.9%, 90.3%, 87.2%, and 88.6% respectively. One year and two years DFI for each HAN-MI-RADS score showed a statistically significant difference while it was not for OS. The receiver operating characteristic curve analysis showed significantly better outcome predictability of HAN-MI-RADS (area under the curve [AUC] 0.884) than Hopkins (AUC 0.699).<\/jats:p>\n <\/jats:sec>\n \n Conclusions:<\/jats:title>\n A five points HAN-MI-RADS criterion was found promising for response assessment with less equivocal results and statistically significant higher AUC than Hopkins for loco-regional recurrence prediction.<\/jats:p>\n <\/jats:sec>","DOI":"10.4103\/ijnm.ijnm_23_23","type":"journal-article","created":{"date-parts":[[2023,12,21]],"date-time":"2023-12-21T01:04:12Z","timestamp":1703120652000},"page":"334-339","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":3,"title":["Effectiveness of Head-and-Neck Molecular Imaging Reporting and Data System Criterion in Head-and-Neck Squamous Cell Carcinoma PostConcurrent Chemoradiotherapy"],"prefix":"10.25259","volume":"38","author":[{"given":"Manoj","family":"Gupta","sequence":"first","affiliation":[{"name":"Department of Nuclear Medicine, Rajiv Gandhi Cancer Institute and Research Centre, New Delhi, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ankush","family":"Jajodia","sequence":"additional","affiliation":[{"name":"Department of Radiology, Juravinski Hospital, McMaster University, Hamilton, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Parveen","family":"Ahlawat","sequence":"additional","affiliation":[{"name":"Department of Radiotherapy, Rajiv Gandhi Cancer Institute and Research Centre, New Delhi, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Munish","family":"Gairola","sequence":"additional","affiliation":[{"name":"Department of Radiotherapy, Rajiv Gandhi Cancer Institute and Research Centre, New Delhi, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mudit","family":"Agarwal","sequence":"additional","affiliation":[{"name":"Department of Surgical Oncology, Rajiv Gandhi Cancer Institute and Research Centre, New Delhi, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sumit","family":"Goyal","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology, Rajiv Gandhi Cancer Institute and Research Centre, New Delhi, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Parv","family":"Mehta","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine, Rajiv Gandhi Cancer Institute and Research Centre, New Delhi, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Partha Sarathi","family":"Choudhury","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine, Rajiv Gandhi Cancer Institute and Research Centre, New Delhi, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"10894","published-online":{"date-parts":[[2023,12,20]]},"reference":[{"key":"R1-20240902","doi-asserted-by":"crossref","first-page":"209","DOI":"10.3322\/caac.21660","article-title":"Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries","volume":"71","author":"Sung","year":"2021","journal-title":"CA Cancer J Clin"},{"key":"R2-20240902","doi-asserted-by":"crossref","first-page":"7","DOI":"10.3322\/caac.21332","article-title":"Cancer statistics, 2016","volume":"66","author":"Siegel","year":"2016","journal-title":"CA Cancer J Clin"},{"key":"R3-20240902","doi-asserted-by":"crossref","first-page":"289","DOI":"10.2214\/AJR.17.18301","article-title":"Clinical practice in PET\/CT for the management of head and neck squamous cell cancer","volume":"209","author":"Goel","year":"2017","journal-title":"AJR Am J 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Am J Roentgenol"},{"key":"R13-20240902","doi-asserted-by":"crossref","first-page":"1097","DOI":"10.1016\/j.jacr.2018.05.006","article-title":"ACR neck imaging reporting and data systems (NI-RADS): A white paper of the ACR NI-RADS committee","volume":"15","author":"Aiken","year":"2018","journal-title":"J Am Coll Radiol"},{"key":"R14-20240902","doi-asserted-by":"crossref","first-page":"2491","DOI":"10.1002\/hed.27160","article-title":"Posttreatment FDG-PET\/CT Hopkins criteria predict locoregional recurrence after definitive radiotherapy for oropharyngeal squamous cell carcinoma","volume":"44","author":"Miller","year":"2022","journal-title":"Head Neck"},{"key":"R15-20240902","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/S0140-6736(19)30956-0","article-title":"Nasopharyngeal carcinoma","volume":"394","author":"Chen","year":"2019","journal-title":"Lancet"},{"key":"R16-20240902","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/j.radonc.2020.03.032","article-title":"FDG-PET\/CT scan assessment of response 12 weeks post radical radiotherapy in oropharynx head and neck cancer: The impact of p16 status","volume":"148","author":"Urban","year":"2020","journal-title":"Radiother Oncol"}],"container-title":["Indian Journal of Nuclear 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