{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,25]],"date-time":"2026-05-25T08:05:37Z","timestamp":1779696337979,"version":"3.53.1"},"reference-count":13,"publisher":"Scientific Scholar","issue":"3","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2021,7]]},"abstract":"\n \n \n Glomerular filtration rate (GFR) is an important indicator of renal function. Many methods have been developed to determine GFR in clinical examinations. This study aims to correlate between radionuclide plasma sampling methods (single and double blood samples,\n in vitro<\/jats:italic>\n methods) and\n in vivo<\/jats:italic>\n Gate's method using\n 99m<\/jats:sup>\n Tc-diethylene triamine penta-acetic acid (\n 99m<\/jats:sup>\n Tc-DTPA) renography.\n <\/jats:p>\n <\/jats:sec>\n \n Materials and Methods:<\/jats:title>\n \n 43 patients underwent this study, including 31 renal donors (Group 1) and 12 patients with obstructive uropathy (Group 2). All patients were administered with a range of 5\u20137 mCi of\n 99m<\/jats:sup>\n Tc-DTPA. Then, renography performed simultaneously after injection and GFR calculation followed by Gate's method. Blood samples were collected at 60- and 120-min postinjection, samples were counted by a thyroid uptake system, and GFR was calculated using a single plasma sample method (SPSM) and a double plasma sample method (DPSM).\n <\/jats:p>\n <\/jats:sec>\n \n Results:<\/jats:title>\n \n The mean GFRs calculated by Gate's method in Groups 1 and 2 were 85.8 \u00b1 18.2 ml\/min and 118.4 \u00b1 13.9 ml\/min, respectively. Meanwhile, using the\n in vitro<\/jats:italic>\n blood sampling methods (DPSM and SPSM), the mean GFRs in Group 1 were 73.8 \u00b1 15.4 ml\/min and 56.4 \u00b1 20.9 ml\/min, respectively, and in Group 2 were 116.8 \u00b1 12.9 ml\/min and 106.3 \u00b1 18.5 ml\/min, respectively. There is a high correlation between Gate's method and DPSM in two groups (\n r<\/jats:italic>\n = 0.86 and 0.72, respectively), and a moderate correlation was found between Gate's method and SPSM in both groups (\n r<\/jats:italic>\n = 0.49 and\n r<\/jats:italic>\n = 0.37, respectively). The two\n in vitro<\/jats:italic>\n methods (DPSM and SPSM) revealed that moderate correlation in both groups (\n r<\/jats:italic>\n = 0.74 and\n r<\/jats:italic>\n = 0.67, respectively) was observed.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion:<\/jats:title>\n \n Renography is a simple method but considered inaccurate for GFR determination. However,\n in vitro<\/jats:italic>\n plasma sampling is rarely used in Vietnam. In this study, Gate's method correlated well with DPSM and tended to overestimate GFR. Further, the\n in vitro<\/jats:italic>\n methods can be applied to correct the\n in vivo<\/jats:italic>\n method as a confirmatory test in some cases.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.4103\/ijnm.ijnm_240_20","type":"journal-article","created":{"date-parts":[[2021,9,22]],"date-time":"2021-09-22T16:00:34Z","timestamp":1632326434000},"page":"300-303","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":2,"title":["Comparison between Three Techniques for Determining Glomerular Filtration Rates"],"prefix":"10.25259","volume":"36","author":[{"given":"Thang Nguyen","family":"Quoc","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kim Dung Nguyen","family":"Thi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tung Pham","family":"Dang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huy Luong","family":"Xuan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Truong Thanh","family":"Tung","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"10894","reference":[{"key":"R1-11-20240902","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1172\/JCI100690","article-title":"The excretion of inulin, xylose and urea by normal and phlorizinized man","volume":"14","author":"Shannon","year":"1935","journal-title":"J Clin Invest"},{"key":"R2-11-20240902","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1007\/BF02987852","article-title":"Reappraisal of single-sample and gamma camera methods for determination of the glomerular filtration rate with99mTc-DTPA","volume":"14","author":"Kazuo","year":"2000","journal-title":"Ann Nucl Med"},{"key":"R3-11-20240902","first-page":"169","article-title":"Glomerular filtration rate measurement in man by the single injection method using 51Cr-EDTA","volume":"37","author":"Chantler","year":"1969","journal-title":"Clin Sci"},{"key":"R4-11-20240902","first-page":"1243","article-title":"Measurement of glomerular filtration rate: single injection plasma clearance method without urine collection","volume":"26","author":"C D","year":"1985","journal-title":"J Nucl Med"},{"key":"R5-11-20240902","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1097\/00003072-198309000-00003","article-title":"Split renal function testing using Tc-99m DTPA A rapid technique for determining differential glomerular filtration","volume":"8","author":"Gates","year":"1983","journal-title":"Clin Nucl Med"},{"key":"R6-11-20240902","doi-asserted-by":"crossref","first-page":"565","DOI":"10.2214\/ajr.138.3.565","article-title":"Glomerular filtration rate: Estimation from fractional renal accumulation of 99mTc-DTPA (stannous)","volume":"138","author":"Gates","year":"1982","journal-title":"AJR Am J Roentgenol"},{"key":"R7-11-20240902","first-page":"1243","article-title":"Measurement of glomerular filtration rate: Single injection plasma clearance method without urine collection","volume":"26","author":"Russell","year":"1985","journal-title":"J Nucl Med"},{"key":"R8-11-20240902","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1016\/S0022-3476(78)80601-5","article-title":"\u201cGeometric method for measuring body surface area: a height-weight formula validated in infants, children, and adults.,\u201d","volume":"93","author":"Haycock","year":"1978","journal-title":"J Pediatr"},{"key":"R9-11-20240902","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1186\/1471-2458-8-117","article-title":"Prevalence of chronic kidney disease in population-based studies: Systematic review","volume":"8","author":"Zhang","year":"2008","journal-title":"BMC Public Health"},{"key":"R10-11-20240902","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1038\/s41581-019-0191-y","article-title":"Measured and estimated glomerular filtration rate: current status and future directions","volume":"16","author":"Levey","year":"2020","journal-title":"Nat Rev Nephrol"},{"key":"R11-11-20240902","first-page":"1211","article-title":"Methods for measuring GFR with technetium-99m-DTPA: An analysis of several common methods","volume":"31","author":"Mulligan","year":"1990","journal-title":"J NucI Med"},{"key":"R12-11-20240902","doi-asserted-by":"crossref","first-page":"1306","DOI":"10.1111\/j.1600-6143.2005.00861.x","article-title":"MDRD equations for estimation of GFR in renal transplant recipients","volume":"5","author":"Poge","year":"2005","journal-title":"Am J Transplant"},{"key":"R13-11-20240902","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1007\/BF03027405","article-title":"Prediction of two-sample (99m)Tc-diethylene triamine pentaacetic acid plasma clearance from single-sample method","volume":"19","author":"Li","year":"2005","journal-title":"Ann Nucl Med"}],"container-title":["Indian Journal of Nuclear Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.lww.com\/10.4103\/ijnm.ijnm_240_20","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,25]],"date-time":"2026-05-25T07:37:39Z","timestamp":1779694659000},"score":1,"resource":{"primary":{"URL":"https:\/\/ijnm.co.in\/comparison-between-three-techniques-for-determining-glomerular-filtration-rates-99mtc-diethylene-triamine-penta-acetic-acid-renography-double-plasma-sampling-method-and-single-plasma-sampling-metho\/"}},"subtitle":["99mTc-Diethylene Triamine Penta-Acetic Acid Renography, Double Plasma Sampling Method, and Single Plasma Sampling Method in Vietnamese Patients"],"short-title":[],"issued":{"date-parts":[[2021,7]]},"references-count":13,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2021]]}},"URL":"https:\/\/doi.org\/10.4103\/ijnm.ijnm_240_20","relation":{},"ISSN":["0972-3919"],"issn-type":[{"value":"0972-3919","type":"print"}],"subject":[],"published":{"date-parts":[[2021,7]]}}}